Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma

Alaeddini, Mojgan; Etemad‐Moghadam, Shahroo

doi:10.1016/j.bjorl.2015.06.008

Cited by 13 publications

(7 citation statements)

References 28 publications

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“…In the current study, a similar proportion in the 3 groups was evidenced, with a significantly higher number of CD34+ than D2‐40+ microvessels. Although without age group distinction, similar results were observed assessing OSCC and lip SCC patients. To date, there are only 2 studies assessing angiogenesis and lymphangiogenesis in young OSCC patients, which indicate that possibly the tumor aggressiveness in young OSCC patients, reported in other studies, cannot be associated with the MVD levels.…”

Section: Discussionmentioning

confidence: 99%

Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study

et al. 2019

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Background M2 macrophages are often detected in oral squamous cell carcinoma (OSCC), which, influenced by hypoxic conditions, appear to have high angiogenesis‐inducing capacity. However, the effects of immunosenescence on tumor‐associated macrophages (TAMs) and angiogenesis in OSCC are unknown. Methods Fifty‐seven OSCCs were divided into 3 groups (I: <40 years [n = 17]; II: 40‐65 years [n = 20]; III: >65 years [n = 20]). Immunohistochemistry for CD68 and CD163 (TAMs), and CD34 and D2‐40 for microvessel density (MVD), microvessel area (MVA), and total vascular area (TVA) were performed. Results All groups showed similar clinicopathological and immunohistochemical findings. Similar CD68 and CD163 expression, confirmed a M2 phenotype. MVD, MVA, and TVA were similar, however, with significant predominance of blood vessels. No significant correlation between macrophage and angiogenic markers was observed. Conclusions A similar TAM and angiogenesis profile suggests the participation of other mechanisms, instead immunosenescence, in young and elderly OSCC patients.

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Section: Discussionmentioning

confidence: 99%

Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study

et al. 2019

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“…18 When comparing these sites, a worse outcome has been suggested for oral tumors. 13,14 Not many studies have compared EMT and CCI in malignancies and it is not clear which pattern is more aggressive or whether they are fundamentally any different in terms of invasion into adjacent or distant tissues. Basic investigations on CCI, have suggested particular advantages of this pattern over EMT in terms of neoplastic progression.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,5,8,12 There are limited studies on the invasion pattern of OSCC 3,12 ; however, similar investigations in lip SCCs have not been performed. OSCC typically has a worse prognosis than lower lip SCC 13,14 which might be related to a number of factors including their different molecular expression profiles. Neoplastic invasion that is known to occur in two main patterns of EMT and CCI with specific immunohistochemical profiles 3,4,12 is an important factor in metastasis which has a major effect on prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the differences in the biologic and clinical behaviors of oral and lip SCCs, various neoplastic aspects have been compared between these sites. 13,14 Conforming to these studies we aimed to compare the invasion modes of lower lip and OSCCs, using the immunohistochemical expression of ECad, NCad, and Pod proteins. We were not able to find previous research in this regard.…”

Section: Introductionmentioning

confidence: 99%

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Pattern of invasion in squamous cell carcinomas of the lower lip and oral cavity

Etemad‐Moghadam

Alaeddini

2017

Journal of Oral Biology and Craniofacial Research

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“…The exact pathogenesis of TSCC has not been uncovered till date. Tumor microenvironment (TME) of TSCC plays a crucial role in its origination and progression, in which new growth of blood vessels, namely "tumor angiogenesis" can transport blood supply, nutrient and oxygen to the tumors and stimulate the proliferation of cancer cells, while new formation of lymph vessels, namely "tumor lymphogenesis" actively contributes to cancer dissemination via the newly formed lymphatic vessels [2,3].…”

Section: Introductionmentioning

confidence: 99%

Neoneurogenesis in squamous cell carcinoma of tongue: a promoter to its progression and metastasis

Jie

Xiang

et al. 2020

Preprint

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Background : To explore whether neoneurogenesis is a predisposing factor to the development and metastasis of squamous cell carcinoma of tongue (TSCC) . Methods: Twenty patients diagnosed with TSCC were included. The objectives were divided into 4 groups according to WHO T-stage standard (five cases in each group) and 2 groups based on lymph node metastasis or not. Detection of neoneurogenesis in paraffin sections from primary tongue cancer tissues was stained by Neurofilament-Light chain antibody (NF-L) using immunohistochemistry method (IHC). The number of new growth nerve fiber bundles was calculated in each randomized view from 3 non-overlapping microscope fields of each tumor section under a light microscope at X 200. Differences in the density of nerve fiber bundles among the T-stage groups and lymph node metastasis groups were calculated using Chi-square test. An ɑ level of 0.05 was considered statistically significant. Results: The age of patients varied from 33 to 74 years with a mean age of 56.10±11.18 years. Males were affected predominantly with a ratio of 1.5:1 to females. IHC staining of NF-L was positive in all 20 paraffin sections of TSCC which suggested that newly growth nerves (namely neoneurogenesis) were observed in tumor mciroenvironment. The intensity of newly formed nerve bundles increased with T stage, and the difference was statistically significant between early stage (T1、T2) and late stage (T3、T4) (p=0.000). Increased prevalence of newly growth nerve bundles correlated significantly to the cervical lymph node metastasis (p=0.000). Conclusions: Neoneurogenesis in tumor microenviroment of TSCC is a predisposing factor to its aggressive development and cervical lymph node metastasis. From a therapeutic perspective, further studies on the topic may provide a new clinical opportunity through anti-neurogenesis.

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Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma

Abstract: According to our results, it seems that the search for additional factors other than those related to the vasculature should continue, to help clarify the differences in biologic behavior between lower lip and oral cavity squamous cell carcinomas.

Cited by 13 publications

References 28 publications

Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study

Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study

Pattern of invasion in squamous cell carcinomas of the lower lip and oral cavity

Neoneurogenesis in squamous cell carcinoma of tongue: a promoter to its progression and metastasis

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