Endoscopic management of adult-type rhabdomyoma of the glottis: case report and review of the literature

Carta, Filippo; Sionis, Sara; Gerosa, Clara; Puxeddu, Roberto

doi:10.1016/j.bjorl.2015.04.008

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…In the larynx, adult-type RM usually occurs as a solitary lesion in adulthood, is more frequent in men than in women, and more frequently involves the glottic and supraglottic regions [ 7 – 38 ]. In our case, the oldest patient in which an adult-type RM has been reported, the tumor involved primarily the arytenoid, an uncommon site of development for this neoplasm [ 18 , 24 , 28 , 29 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Even though the head and neck region is the most common area of extracardiac RM [ 1 – 3 ], this tumor is extremely rare in the larynx [ 7 – 38 ]. For this reason, we describe the clinicopathologic features of an adult-type RM of the larynx diagnosed in an 85-year-old woman and review the pertinent literature with the specific aim to assess the diagnostic and therapeutic standards for this uncommon tumor that are invariably necessary to avoid erroneous diagnosis and inappropriate treatment.…”

Section: Introductionmentioning

confidence: 99%

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Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location

Altissimi

Ralli

Sementilli

et al. 2017

Case Reports in Otolaryngology

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Rhabdomyoma is an uncommon benign mesenchymal tumor with skeletal muscle differentiation that may occur either in the heart or in extracardiac sites. Even though the head and neck region is the most common area of extracardiac rhabdomyoma, the larynx is rarely involved. We present the case of an 85-year-old woman who reported a 10-day history of breathing difficulties, dysphagia, and dysphonia. A computed tomography scan of the head and neck showed a contrast-enhanced, solid hypopharyngeal-laryngeal neoplasm with well-defined margins causing subtotal obliteration of the right pyriform sinus and a reduction in air lumen of the laryngeal vestibule. The patient underwent complete endoscopic removal of the lesion; histologic examination revealed an adult-type rhabdomyoma based on the histologic features and the immunoreactivity of the neoplastic cells for desmin, myoglobin, and muscle-specific actin but not for cytokeratin, S-100, CD68R, chromogranin-A, and synaptophysin. Since clinical and imaging features are not specific for rhabdomyoma, histologic examination and immunohistochemical analyses play a central role in the differential diagnosis of the adult-type rhabdomyoma from other laryngeal neoplasms. A correct diagnosis is mandatory to avoid inappropriate treatment.

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