Larynx: Anatomy, Nonneoplastic, Benign, and Malignant

Brandwein‐Weber, Margaret

doi:10.1007/978-3-319-76106-0_5

Cited by 1 publication

(1 citation statement)

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“…2 Around 50% of ACC develops on the hard palate, the rest occurring in other intraoral locations such as the lower lip, the region of the retromolar/tonsillar pillar, the sublingual gland and the buccal mucosa. 3 In addition to salivary glands, ACC may infrequently occur in the esophageal, bronchial, and mammary glands. 4 Due to the relatively low frequency of minor glands in the larynx (23-57 glands / cm2) compared to the oral cavity (600-1000 glands / cm2), LACC is sporadic (1% of all laryngeal cancer).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical analysis of CD34 and PCNA expression in salivary and laryngeal adenoid cystic carcinoma

El-Azab

Alqalshy

El-Rahman

et al. 2021

ijhs

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Background/purpose: Adenoid cystic carcinomas (ACC) are malignant tumors that affect major and minor salivary glands. LACC is an extremely rare location for this type of tumour. This study describes the immunohistochemical analysis of CD34 and PCNA expression in salivary and laryngeal ACC. Materials and methods: The study included 40 formalin-fixed paraffin-embedded blocks were used, 20 of them were previously diagnosed as SACC, and 20 as LACC. All sections were stained with hematoxylin and eosin (H&E) and immunohistochemical marker to detect CD34 and PCNA protein. Results: Regarding the expression of CD34, SACC had recorded the highest mean area % (31.58), while LACC recorded the lowest mean area % (14.25) and the comparison revealed that there was a highly significant difference between these lesions where P value was (<0.001) concerning the expression of PCNA, SACC had recorded the highest mean area % (36.28), while LACC recorded the lowest mean area % (20.7) and the comparison revealed that there was a highly significant difference between these lesions where P value was (<0.001). Conclusions: immunohistochemical analyses presented here indicated that LACC tends to nonaggressive oncological behavior and angiogenesis when compared to SACC.

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Section: Introductionmentioning

confidence: 99%