Changing cycles: the necessary rupture to achieve excellence

Bacteriological analysis of isolated chronic sinusitis without polyps

“…Studies on the toll like receptors of the respiratory epithelium (TLR) demonstrated that TLR-2 binds to Gram-positive bacteria and certain fungi, TLR-3 to viruses, and TLR-4 to Gram-negative bacteria. An increased expression of TLR-2 and TLR-4 was found in CRSsNP [ 19 ]. The interaction between S. aureus and endothelial cells results from the connections between fibronectin-binding proteins (FnBPs) on bacteria and fibronectin and heat shock proteins 60 (Hsp60) [ 20 ].…”

“…There are conflicting reports in the literature concerning the significance of nasal cavity anatomy differences such as nasal septum deviation, concha bullosa, big agger nasi or the presence of Haller cells in the aetiology of chronic sinusitis [ 19 ]. We have found abnormalities in the anatomy of the nasal septum or middle nasal concha in four cases, which could have contributed to the formation of inflammatory lesions in the sinus, which seems to be less important in the aetiology of the disease compared with the bacteriological image.…”

BJORL: moving forward, always

“…Our responsibility increases as we face the challenges over the next few years, from the changes and transience of government policies to the training/qualification of our specialists in several courses in this continental country. As Dr. Sady 1 stated in his editorial, we are still far from our ideal. We need to create official mechanisms to consolidate new groups of national researchers with international projection.…”

“…When we decided to write the final editorial for this year's BJORL, we recalled the editorials of 2013 and reviewed what our friends wrote celebrating the journal's 80th birthday. Dr. Sady's editorial 1 brilliantly, critically and analytically called our attention, to a need for significant changes in the near future to. But, paradoxically, this necessity to take the next steps forward forced us to look back.…”

“… 2 , 3 , 4 It was then that we envisioned the scope and challenge of condensing this history into some pages without overlooking names, facts and attitudes. But also to have it guidelines for continuity as proposed by Dr. Sady, 1 so that years later a colleague would recognize that the most important history is the one he or she is writing at the moment, since it depicts what we are doing today as well as what they did before, before any of us. At the same time we recognize that the greatness of our history has already been documented expressly in the many journal issues that embody 85 years of thinking and practice of our professional colleagues in our specialty in Brazil, leaving us only to humbly compile some facts and authors along this journey.…”