Brainstem auditory evoked potentials in children with lead exposure

Alvarenga, Kátia de Freitas; Morata, Thaís C.; Lopes, Andréa Cintra; Feniman, Mariza Ribeiro; Jacob-Corteletti, Lílian Cássia Bórnia

doi:10.1016/j.bjorl.2013.12.001

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…However other studies found no association between concurrent blood lead and ABRs in older children [ 14 – 17 , 22 ]. Two studies of multi-age cohorts, ranging from toddlers to teenagers, without age-specific analyses, also found no association between concurrent blood lead and auditory function [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Low-level prenatal lead exposure and infant sensory function

Silver

Liu

et al. 2016

Environ Health

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BackgroundLead is a pervasive neurotoxicant that has been associated with poorer cognitive, behavioral, and motor outcomes in children. The effects of lead on sensory function have not been well characterized. The aim of this study was to assess the effects of prenatal lead exposure on infant sensory function, as measured by auditory brainstem response (ABR) and grating visual acuity (VA).MethodsLead was measured in maternal blood in mid- and late-pregnancy (mean gestational age = 15.5 and 39.0 weeks, respectively) and umbilical cord blood in a cohort of full-term infants in rural northeastern China. ABR latencies (peaks I, III, V) were measured in newborns during unsedated sleep (n = 315). The ABR central-to-peripheral (C-P) ratio was calculated as the ratio between the III-V and I-III interpeak intervals. VA was measured in 6-week-olds using Teller Acuity Cards (n = 1019) and assigned as the narrowest grid the infant fixated on. Multivariate linear regression was used to evaluate relationships between tertiles of mid-pregnancy, late-pregnancy, or cord lead and newborn ABR or 6-week VA.ResultsHigher late-pregnancy lead levels were associated with higher ABR C-P ratios and lower VA. In covariate-adjusted analyses, mean C-P ratios were 4.6 and 3.2 % higher in infants whose mothers had lead > 3.8 μg/dL and lead = 2–3.8 μg/dL, respectively, than for infants whose mothers had lead < 2 μg/dL (p-trend =0.002). In adjusted analyses for VA, mean scores were 8.5 and 7.2 % lower for maternal lead > 3.8 μg/dL and lead = 2–3.8 μg/dL, respectively, compared to lead < 2 μg/dL (p-trend =0.009).ConclusionAuditory and visual systems maturation appears delayed in infants with higher prenatal lead exposure during late-pregnancy, even at relatively low levels. Both systems start myelinating in late gestation and mature rapidly in infancy. Higher ABR C-P ratio and lower grating VA scores suggest effects of low-level lead exposure on sensory system myelination.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0148-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Low-level prenatal lead exposure and infant sensory function

Silver

Liu

et al. 2016

Environ Health

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“…However, results obtained in some studies are contradictory (Jeyaratnam et al 1985, Alvarenga et al 2015. Nevertheless, these are very important questions and can be answered by pursuing these studies with a large number of patients.…”

Section: Role Of Lead In the Cns 115mentioning

confidence: 92%

“…Alvarenga et al (2015) examined the BAEP in children with lead exposure. The study included 130 children (80 males and 50 females) aged 18 months to 14 years (mean: 6 years, 8 months ± 2 years, 3 months) living near a battery factory that contaminated the nearby soil and river with lead.…”

Section: Role Of Lead In the Cns 113mentioning

confidence: 99%

Role of Lead in the Central Nervous System: Effect on Electroencephlography, Evoked Potentials, Electroretinography, and Nerve Conduction

Sindhu

Sutherling

2015

The Neurodiagnostic Journal

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The toxic effects of lead on the brain are well known, but its effects on EEG and evoked potentials (EPs) are not generally known in the neurodiagnostic community. Despite public health efforts, lead is still widely present at low levels in the environment. Even at low concentrations, lead is known to cause biochemical and physiological dysfunction. The present article reviews the effects of lead exposure on the central nervous system, with a special emphasis on the developing brain. Additionally, it describes the effects of lead on EEG, EPs, electroretinography, and nerve conduction studies.

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“…Alvarenga et al [76] used pure-tone audiometry, ABR and transient-evoked OAE (TEOAE) to investigate the association between these tests and low but long-term lead exposure in 130 children living near a battery factory. Blood lead levels were monitored for 35.5 months and audiological evaluations were carried out once.…”

Section: Effects Of Heavy Metals On the Human Auditory Systemmentioning

confidence: 99%

The Adverse Effects of Heavy Metals with and without Noise Exposure on the Human Peripheral and Central Auditory System: A Literature Review

Castellanos

Fuente

2016

IJERPH

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Exposure to some chemicals in the workplace can lead to occupational chemical-induced hearing loss. Attention has mainly focused on the adverse auditory effects of solvents. However, other chemicals such as heavy metals have been also identified as ototoxic agents. The aim of this work was to review the current scientific knowledge about the adverse auditory effects of heavy metal exposure with and without co-exposure to noise in humans. PubMed and Medline were accessed to find suitable articles. A total of 49 articles met the inclusion criteria. Results from the review showed that no evidence about the ototoxic effects in humans of manganese is available. Contradictory results have been found for arsenic, lead and mercury as well as for the possible interaction between heavy metals and noise. All studies found in this review have found that exposure to cadmium and mixtures of heavy metals induce auditory dysfunction. Most of the studies investigating the adverse auditory effects of heavy metals in humans have investigated human populations exposed to lead. Some of these studies suggest peripheral and central auditory dysfunction induced by lead exposure. It is concluded that further evidence from human studies about the adverse auditory effects of heavy metal exposure is still required. Despite this issue, audiologists and other hearing health care professionals should be aware of the possible auditory effects of heavy metals.

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Brainstem auditory evoked potentials in children with lead exposure

Cited by 12 publications

References 23 publications

Low-level prenatal lead exposure and infant sensory function

Low-level prenatal lead exposure and infant sensory function

Role of Lead in the Central Nervous System: Effect on Electroencephlography, Evoked Potentials, Electroretinography, and Nerve Conduction

The Adverse Effects of Heavy Metals with and without Noise Exposure on the Human Peripheral and Central Auditory System: A Literature Review

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