Accuracy of heparin binding protein: as a new marker in prediction of acute bacterial meningitis

Kandil, Mahrous; Khalil, Gihane Ibrahim; El-Attar, Eman; Shehata, Gihan M.; Hassan, Salwa K.

doi:10.1016/j.bjm.2018.05.007

Cited by 18 publications

(17 citation statements)

References 19 publications

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“…A recent study [80] in 2018 concurred with and confirmed these results. This study was the first study to investigate serum HBP in meningitis and to correlate between CSF and serum HBP.…”

Section: Hbp In Acute Bacterialsupporting

confidence: 69%

“…[76] Acute bacterial meningitis HBP levels in cerebrospinal fluid and in serum were significantly higher in patients diagnosed with bacterial meningitis. [79,80] Leptospirosis High levels of HBP were detected in serum from patients diagnosed with leptospirosis, particularly at the early phase of the disease. [32] AKI: acute kidney injury; ALI: acute lung injury; ARDS: acute respiratory distress syndrome; HBP: heparin-binding protein.…”

Section: Hbp In Various Diseasesmentioning

confidence: 99%

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A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction

Yang

Liu

et al. 2019

Journal of Immunology Research

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Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis.

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“…A recent study [80] in 2018 concurred with and confirmed these results. This study was the first study to investigate serum HBP in meningitis and to correlate between CSF and serum HBP.…”

Section: Hbp In Acute Bacterialsupporting

confidence: 69%

Section: Hbp In Various Diseasesmentioning

confidence: 99%

A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction

Yang

Liu

et al. 2019

Journal of Immunology Research

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“…The results of a meta-analysis ( 18 ) demonstrated that HBP can be used as a serum biomarker to identify bacterial infections. Kandil et al ( 19 ) concluded that HBP is involved in severe bacterial infections and, therefore, can be used as a potential diagnostic marker and therapeutic target for sepsis. They also reported that elevated HBP levels in the CSF can distinguish patients with acute bacterial meningitis from those with other central nervous system infections ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of heparin-binding protein in the cerebrospinal fluid for purulent meningitis in children

Ren

Wu²,

et al. 2021

Braz J Med Biol Res

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This study aimed to investigate the diagnostic value of heparin-binding protein (HBP) in the cerebrospinal fluid of children with purulent meningitis (PM). This study included 118 children with PM diagnosed at our hospital from January 2018 to January 2020, 110 children with viral meningitis (VM) and 80 children with suspected meningitis who were ruled out by cerebrospinal fluid (CSF) analysis during the same period. HBP and white blood cell (WBC) count in the CSF, and inflammatory factors, including C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and procalcitonin (PCT), were measured. Receiver-operator characteristic curves were used to analyze the predictive value of HBP, CRP, PCT, and TNF-α levels in the diagnosis of PM by CSF analysis. HBP levels in the CSF of children with PM were higher, while the CRP and serum PCT and TNF-α levels were elevated in all groups (P<0.05). In addition, HBP levels in the CSF were more accurate for the diagnosis of PM than traditional diagnostic indexes. HBP levels in the CSF can be used as an important reference for early diagnosis of PM.

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“… 19 HBP is positively correlated with PCT levels and may therefore also serve as an indirect biomarker for early diagnosis of infection. 20 It has been studied in several acute diseases, such as acute kidney injury, 21 acute lung injury, 22 bacterial skin infection, 23 acute bacterial meningitis, 24 but rarely in AP. IL‐6 is one of the more well‐studied cytokines that rapidly decreases within 48 h unless severe infection persists.…”

Section: Discussionmentioning

confidence: 99%

Combined detection of procalcitonin, heparin‐binding protein, and interleukin‐6 is a promising assay to diagnose and predict acute pancreatitis

Zhong

Wang

et al. 2021

Clinical Laboratory Analysis

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Background Acute pancreatitis (AP), one of the most common clinical emergencies, is characterized by variable clinical features and inadequate diagnostic methods. At present, the commonly used indicators do not have high specificity and do not necessarily reflect disease severity. We therefore aimed to investigate diagnostic and prognostic value of plasma procalcitonin, heparin‐binding protein, and interleukin‐6 for acute pancreatitis by separate detection and joint detection. Methods The study involved 451 participants, including 343 AP patients and 108 healthy controls. We analyzed the association of the three biomarkers with the severity and prognosis of AP. Results A statistically significant increase in the mean plasma analyte levels was detected in the study group compared to the control group. Multivariate comparison showed that plasma levels of PCT, HBP, and IL‐6 were all significantly different among the three groups at different sampling times (1st, 3rd, 7th, and 10th day of admission) (p < 0.01). The combination of the three indicators had significantly higher diagnostic value than either the individual markers or pairwise combinations (p < 0.001). The levels of the three were all significantly higher in severe acute pancreatitis (SAP) patients than in non‐SAP patients (p < 0.001); meanwhile, patients with high levels had a worse prognosis than those with low levels (p < 0.05). In multivariate analysis adjusted for age and sex, high levels of PCT, HBP, and IL‐6 were found to be independently associated with the development of AP. Conclusions It dramatically improved the diagnostic power of AP when PCT, HBP, and IL‐6 were combined; high PCT, HBP, and IL‐6 levels within 3 days of admission may be the potentially useful indicators for predicting SAP.

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Accuracy of heparin binding protein: as a new marker in prediction of acute bacterial meningitis

Abstract: Serum Heparin-binding protein serves as a non-invasive potential marker of acute bacterial meningitis even in partially treated cases.

Cited by 18 publications

References 19 publications

A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction

A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction

Diagnostic value of heparin-binding protein in the cerebrospinal fluid for purulent meningitis in children

Combined detection of procalcitonin, heparin‐binding protein, and interleukin‐6 is a promising assay to diagnose and predict acute pancreatitis

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