A high prevalence of human papillomavirus 16 and 18 co-infections in cervical biopsies from southern Brazil

Jesus, Sheile Pinheiro de; Costa, Ana Carla Marques da; Barcellos, Regina Bones; Medeiros, Rúbia Marília de; Silva, Cláudia Maria Dornelles da; Rossetti, Maria Lúcia Rosa

doi:10.1016/j.bjm.2018.04.003

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…Most importantly, although HPVs 16 and 18 are the most frequently observed high-risk HPVs globally and were the focus of studies conducted in the GCC and MENA regions, nevertheless, based on our findings on HPV genotyping in this region, they do not appear to be the most prevalent types [ 32 , 50 , 65 ]. Globally, numerous reports from France [ 66 ], Brazil [ 67 ], and Cuba [ 40 ] have shown HPV types 16 and 18 to be the most oncogenic HPVs associated with the pathogenesis of CRC. However, the frequent observation of these two HPVs in Western countries cannot be extrapolated to other ethnic populations.…”

Section: Discussionmentioning

confidence: 99%

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

et al. 2023

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High-risk human papillomaviruses (HPVs) are considered risk factors in the origin of several human malignancies, such as breast, cervical, head and neck, as well as colorectal cancers. However, there are no data reported on the HPV status in colorectal cancer in the State of Qatar. Therefore, we herein examined the presence of high-risk HPVs (16, 18, 31, 33, 35, 45, 51, 52, and 59), using polymerase chain reaction (PCR) in a cohort of 100 Qatari colorectal cancer patients, and their association with tumor phenotype. We found that high-risk HPV types 16, 18, 31, 35, 45, 51, 52, and 59 were present in 4, 36, 14, 5, 14, 6, 41, and 17% of our samples, respectively. Overall, 69 (69%) of the 100 samples were HPV positive; among these, 34/100 (34%) were positive for single HPV subtypes, while 35/100 (35%) of the samples were positive for two or more HPV subtypes. No significant association was noted between the presence of HPV and tumor grade, stage, or location. However, the presence of coinfection of HPV subtypes strongly correlated with advanced stage (stage 3 and 4) colorectal cancer, indicating that the copresence of more than one HPV subtype can significantly worsen the prognosis of colorectal cancer. The results from this study imply that coinfection with high-risk HPV subtypes is associated with the development of colorectal cancer in the Qatari population.

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Section: Discussionmentioning

confidence: 99%

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

et al. 2023

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“…A população incluída foi de 1.632 amostras/pacientes, variando entre n = 25 e n = 445. A faixa etária das pacientes foi de 14 a 60 anos, sendo que em três artigos constava somente a informação da idade média da população estudada 12,13,14 Dois autores relataram o uso de citologia convencional 17,18 ; quatro, de citologia convencional e em meio líquido 13,15,16,19 ; e em dois estudos não foi possível identificar o tipo de técnica citológica empregada. Três artigos incluíram o uso do esfregaço cervical/colpocitologia/ Papanicolau 13,15,17 ; dois utilizaram biópsia cervical 14,19 ; um aplicou a combinação de esfregaço cervical + colposcopia 16 ; um empregou o exame citopatológico cervical + biópsia cervical 18 ;…”

Section: Resultsunclassified

Infecção pelo Hpv na região Sul do Brasil: uma revisão integrativa da literatura

Ataides¹,

Calil²,

Mezzomo³

2023

Rev. baiana de saúde pública

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O papilomavírus humano (HPV) infecta pele e mucosas e causa, na grande maioria dos casos, lesões transitórias que podem evoluir para câncer. O objetivo deste estudo é avaliar, por meio de revisão integrativa, a literatura disponível sobre a frequência da infecção pelo HPV na região Sul do Brasil. Buscou-se nas bases de dados PubMed, Literatura Latino-americana e do Caribe em Ciências da Saúde (Lilacs) e Scientific Electronic Library Online (SciELO) a frequência de HPV na região Sul do Brasil nos últimos dez anos. Foram identificados oito estudos que se enquadraram nos critérios da pesquisa. A prevalência estimada de infecção pelo HPV foi de 46,19%. Os genótipos mais encontrados foram HPV 6, de baixo risco, e os subtipos HPV 16, HPV 18, HPV 31 e HPV 58, de alto risco. Nas amostras classificadas como LSIL/HSIL ou de células escamosas atípicas (ASC), tipos virais de baixo risco HPV 6, HPV 11 e HPV 44 foram os mais prevalentes, enquanto para os de alto risco os subtipos HPV 16, HPV 18 e HPV 58 foram os mais encontrados. Embora tenham sido identificados poucos estudos com essa temática nos últimos anos, a partir dos dados da pesquisa foi possível estimar a prevalência do HPV no Sul do Brasil e seus genótipos mais frequentes. Essa informação é importante para o planejamento das ações de saúde pública e dos serviços de saúde, contribuindo para a elaboração de estratégias de controle e prevenção da infecção.

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“…The interest of adding more antigens E6 HPV16 , E6 HPV18, and E7 HPV18 antigens was essentially to broaden the antigen/epitope repertoire with a short‐term perspective of achieving a clinical trial in patients, with polymorphic HLA, infected by HPV16 or HPV18. It is also noteworthy that patients with HPV16 and HPV18 co‐infection have been reported (Jesus et al , 2018 ).…”

Section: Discussionmentioning

confidence: 98%

“…Source data are available online for this figure. with HPV16 and HPV18 co-infection have been reported (Jesus et al, 2018). Most murine HPV tumor models rely on s.c. engraftment.…”

Section: Data Informationmentioning

confidence: 99%

Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine

Douguet,

Fert,

Lopez

et al. 2023

EMBO Mol Med

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Human papillomavirus (HPV) infections are the cause of all cervical and numerous oropharyngeal and anogenital cancers. The currently available HPV vaccines, which induce neutralizing antibodies, have no therapeutic effect on established tumors. Here, we developed an immuno‐oncotherapy against HPV‐induced tumors based on a non‐integrative lentiviral vector encoding detoxified forms of the Early E6 and E7 oncoproteins of HPV16 and 18 genotypes, namely, “Lenti‐HPV‐07”. A single intramuscular injection of Lenti‐HPV‐07 into mice bearing established HPV‐induced tumors resulted in complete tumor eradication in 100% of the animals and was also effective against lung metastases. This effect correlated with CD8+ T‐cell induction and profound remodeling of the tumor microenvironment. In the intra‐tumoral infiltrates of vaccinated mice, the presence of large amounts of activated effector, resident memory, and transcription factor T cell factor‐1 (TCF‐1)+ “stem‐like” CD8+ T cells was associated with full tumor eradication. The Lenti‐HPV‐07‐induced immunity was long‐lasting and prevented tumor growth after a late re‐challenge, mimicking tumor relapse. Lenti‐HPV‐07 therapy synergizes with an anti‐checkpoint inhibitory treatment and therefore shows promise as an immuno‐oncotherapy against established HPV‐mediated malignancies.

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A high prevalence of human papillomavirus 16 and 18 co-infections in cervical biopsies from southern Brazil

Cited by 9 publications

References 20 publications

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

Infecção pelo Hpv na região Sul do Brasil: uma revisão integrativa da literatura

Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine

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