Antibacterial activity of 3,3′,4′-Trihydroxyflavone from Justicia wynaadensis against diabetic wound and urinary tract infection

Dsouza, Dorin; Lakshmidevi, N.

doi:10.1016/j.bjm.2017.05.002

Cited by 9 publications

(4 citation statements)

References 21 publications

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“…It is known as to treat blood stagnation syndrome, ischemia, swelling, necrosis, rheumatic pain, and epigastric pain in Korea and China (Lee et al, ). In previous studies, trihydroxyflavone obtained from crude extract has been reported to have a pharmacological effect of improving diabetic wound, urinary tract infections, antibiotic, antibiotic, and oxidative stress (Dzotam et al, ; Han, Zhu, Chen, Liu, & Dang, ; Dsouza & Nanjaiah, ). However, the effect of THF isolated from D. odorifera on osteoclast differentiation inhibition and osteoblast was not reported.…”

Section: Introductionmentioning

confidence: 99%

6,7,4′‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo

Kim

Lee

et al. 2019

Phytotherapy Research

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The balance between the osteoblasts and the osteoclasts is important for the maintenance of the skeleton of the human body. The osteoclasts absorb bone after differentiated into polymorphonuclear cells by the fusion of monocytes/macrophages. We have found that 6,7,4′‐Trihydroxyflavone (THF), a compound from the heartwood of Dalbergia Odorifera inhibits receptor activator of NF‐κB ligand (RANKL)‐induced osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marrow macrophage. THF significantly inhibited the c‐Jun‐N‐terminal kinase signaling pathway without affecting extracellular signal‐regulated kinase, p38, and AKT signaling. Moreover, THF inhibited the expression of c‐Fos, nuclear factor‐activated T cells cytoplasm 1, cathepsin K, and c‐src by RANKL. We used a lipopolysaccharide (LPS)‐induced bone loss model in mice. Consequently, bone volume per tissue volume, trabecular number's reduction was recovered in THF‐treated mice, and trabecular separation's augmentation was also attenuated by THF administration. In summary, THF inhibits RANKL‐induced osteoclast differentiation by MAPK signaling pathway and inhibits bone resorption by destroying the actin ring in mature osteoclasts. THF also prevented LPS‐induced bone loss in a mice model. Thus, THF may be useful in the treatment of bone diseases associated with excessive osteoclast differentiation and bone resorption.

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Section: Introductionmentioning

confidence: 99%

6,7,4′‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo

Kim

Lee

et al. 2019

Phytotherapy Research

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“…The study elucidated the mechanism of action, inhibition of biofilm formation, pathogenesis, and efflux activity of one of its pure glycyrrhizic acid components [ 167 ]. The findings were validated using molecular docking analysis using ExoS segmentation, which confirmed the potential of the herb G. glabra [ 153 ]. Isolated G. glabra glycosides altered membrane permeability and inhibited efflux activity and biofilm formation by P. aeruginosa [ 166 ].…”

Section: Flavonoids: Structural Characteristics and Subclassesmentioning

confidence: 83%

“…Methanolic fraction of the extract from Justicia wynaadensis contains 3,3,4-trihydroxyflavone that exhibits antimicrobial activity against multiresistant and opportunistic organisms. Flavones can effectively kill bacteria present in diabetic wounds such as Enterococcus faecalis , Streptococcus aureus , Klebsiella pneumoniae , Enterobacter aerogenes , Escherichia coli , and Pseudomonas aeruginosa [ 153 ]. The methanolic extract of J. wynaadensis also showed antibacterial activity against K. pneumoniae (Ponnamma SU2015).…”

Section: Flavonoids: Structural Characteristics and Subclassesmentioning

confidence: 99%

Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds

Chagas

Behrens²,

Tellis³

et al. 2022

Oxidative Medicine and Cellular Longevity

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Plant preparations have been used to treat various diseases and discussed for centuries. Research has advanced to discover and identify the plant components with beneficial effects and reveal their underlying mechanisms. Flavonoids are phytoconstituents with anti-inflammatory, antimutagenic, anticarcinogenic, and antimicrobial properties. Herein, we listed and contextualized various aspects of the protective effects of the flavonols quercetin, isoquercetin, kaempferol, and myricetin and the flavones luteolin, apigenin, 3 ′ ,4 ′ -dihydroxyflavone, baicalein, scutellarein, lucenin-2, vicenin-2, diosmetin, nobiletin, tangeretin, and 5-O-methyl-scutellarein. We presented their structural characteristics and subclasses, importance, occurrence, and food sources. The bioactive compounds present in our diet, such as fruits and vegetables, may affect the health and disease state. Therefore, we discussed the role of these compounds in inflammation, oxidative mechanisms, and bacterial metabolism; moreover, we discussed their synergism with antibiotics for better disease outcomes. Indiscriminate use of antibiotics allows the emergence of multidrug-resistant bacterial strains; thus, bioactive compounds may be used for adjuvant treatment of infectious diseases caused by resistant and opportunistic bacteria via direct and indirect mechanisms. We also focused on the reported mechanisms and intracellular targets of flavonols and flavones, which support their therapeutic role in inflammatory and infectious diseases.

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“…It is assumed that it gives resistance to people from fever and cold and also acts as a deworming agent. It is said that a person suffering from urinary tract infection is advised to consume one glass Justicia plant, which helps, in subsiding the infections (Bhagya et al, 2013;Dsouza and Nanjaiah, 2018).…”

Section: Introductionmentioning

confidence: 99%

Temporal changes of phenolics, flavonoids, carotenoids and mineral constituents in the leaf of a medicinal plant Justicia wynaadensis

Karunakaran¹,

Azeez²,

Tripathi³

et al. 2022

JEB

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Aim: The present study was conducted to investigate the temporal changes in the level of phenolics, flavonoids, carotenoids, and mineral constituents in the leaf extract of medical plant J. wynaadensis (Aati soppu) during monsoon, pre-and post-monsoon season. Methodology: Leaf samples of J. wynaadensis were collected in different seasons (i) first sampling (AS-I) during the onset of monsoon, i.e., first week of July; (ii) second (AS-II) during mid-monsoon (First week of August); and (iii) third sampling (AS-III) during post monsoon (First week of September). The collected samples were analyzed for total carotenoids and chlorophyll, phenolics, flavonoids antioxidant potential, and mineral contents. Individual phenolic acids were identified and quantified using UPLC-H class coupled with TQD-MS/MS. Results: Biochemical constituents significantly varied between the samples of J. wynaadensis collected in different seasons. The samples collected during monsoon season (AS-II) had significantly high amount of phenolics (388.2 mg GAE 100 g-1), flavonoids (287 mg CE 100 g-1), carotenoids (2.40 µg β-CE 100 g-1) when compared with samples collected during pre-and post-monsoon seasons. Among the phenolic acids quantified, Salicylic acid was found to be maximum (2455-4747 μg g-1f.wt.) followed by caffeic acid (350 μg g-1f.wt.). Among the minerals studied potassium was found maximum (240 to 278 mg 100g-1) followed by calcium (263 to 442 mg 100g-1). Leaf samples contained high amount of iron (2.37 to 3.313 mg 100g-1), Except for zinc, most of the micro minerals significantly reduced from onset of monsoon to fag end of monsoon. Interpretation: J. wynaadensis collected at stage AS-II contained significantly high amount of phenolics and flavonoids, which offers numerous health benefits. Increase in content of bioactive phytochemicals such as salicylic acid can be presumed to be responsible for the curative properties of Aati soppu collected during AS-II. Key words: Justicia wynaadensis, Kodagu, Medicinal palnt

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Antibacterial activity of 3,3′,4′-Trihydroxyflavone from Justicia wynaadensis against diabetic wound and urinary tract infection

Cited by 9 publications

References 21 publications

6,7,4′‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo

6,7,4′‐Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo

Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds

Temporal changes of phenolics, flavonoids, carotenoids and mineral constituents in the leaf of a medicinal plant Justicia wynaadensis

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