Phylogenetic characterization of the first Ungulate tetraparvovirus 2 detected in pigs in Brazil

Souza, Carine K.; Streck, André Felipe; Gonçalves, Karla; Pinto, Luciane Dubina; Ravazzolo, Ana Paula; Barcellos, David Emílio dos Santos Neves de; Canal, Cláudio Wageck

doi:10.1016/j.bjm.2016.01.025

Cited by 10 publications

(6 citation statements)

References 18 publications

(47 reference statements)

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“…For example, the presence of the PHoV (also known as porcine partetravirus) nucleotide sequence was investigated in source animals and in islet macrobeads. To date, this virus has not been cultured or isolated and the only evidence of its existence are the findings of the genomic sequence . We have found evidence of the PHoV sequence in various porcine tissues including pancreas, mesenteric lymph nodes, donor serum, and frozen vendor supplied porcine serum used during islet isolation and macrobead culture.…”

Section: Discussionmentioning

confidence: 94%

A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials

Gazda

Collins

Lovatt³

et al. 2016

Xenotransplantation

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Background: The use of porcine islets to replace insulin-producing islet β-cells, destroyed during the diabetogenic disease process, presents distinct challenges if this option is to become a therapeutic reality for the treatment of type 1 diabetes. These challenges include a thorough evaluation of the microbiological safety of the islets. In this study, we describe a robust porcine islet-screening program that provides a high level of confidence in the microbiological safety of porcine islets suitable for clinical trials.

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Section: Discussionmentioning

confidence: 94%

A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials

Gazda

Collins

Lovatt³

et al. 2016

Xenotransplantation

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“…These include the frequent detection of porcine hokovirus in hunted wild boar in Portugal 48 and a bovine hokovirus in domestic yaks 49 . In South America, another hokovirus was found to be endemic in a survey of Brazilian pig herds, in which post-weaning multi-systemic wasting syndrome was common 50 , and a novel porcine hokovirus (referred to as porcine parvovirus 6, or PPV6) has been associated with foetal loss in pigs in China 51 , 52 .…”

Section: New Advances In the Parv4 Literaturementioning

confidence: 99%

Human parvovirus 4 ‘PARV4’ remains elusive despite a decade of study

2017

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Human parvovirus 4 (‘PARV4’) is a small DNA tetraparvovirus, first reported in 2005. In some populations, PARV4 infection is uncommon, and evidence of exposure is found only in individuals with risk factors for parenteral infection who are infected with other blood-borne viruses. In other settings, seroprevalence studies suggest an endemic, age-associated transmission pattern, independent of any specific risk factors. The clinical impact of PARV4 infection remains uncertain, but reported disease associations include an influenza-like syndrome, encephalitis, acceleration of HIV disease, and foetal hydrops. In this review, we set out to report progress updates from the recent literature, focusing on the investigation of cohorts in different geographical settings, now including insights from Asia, the Middle East, and South America, and discussing whether attributes of viral or host populations underpin the striking differences in epidemiology. We review progress in understanding viral phylogeny and biology, approaches to diagnostics, and insights that might be gained from studies of closely related animal pathogens. Crucial questions about pathogenicity remain unanswered, but we highlight new evidence supporting a possible link between PARV4 and an encephalitis syndrome. The unequivocal evidence that PARV4 is endemic in certain populations should drive ongoing research efforts to understand risk factors and routes of transmission and to gain new insights into the impact of this virus on human health.

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“…We detected strains of ungulate tetraparvovirus— a virus in the genus Tetraparvovirus —in cattle from the South of Brazil. Ungulate tetraparvovirus 2 —formerly known as porcine hokovirus—has previously been identified in swine in Brazil [ 31 ]. However, ungulate tetraparvovirus 1 —formerly known as bovine hokovirus—has not previously been reported outside Asia.…”

Section: Discussionmentioning

confidence: 99%

Novel Parvoviruses from Wild and Domestic Animals in Brazil Provide New Insights into Parvovirus Distribution and Diversity

De Souza,

Dennis,

Fumagalli

et al. 2018

Viruses

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Parvoviruses (family Parvoviridae) are small, single-stranded DNA viruses. Many parvoviral pathogens of medical, veterinary and ecological importance have been identified. In this study, we used high-throughput sequencing (HTS) to investigate the diversity of parvoviruses infecting wild and domestic animals in Brazil. We identified 21 parvovirus sequences (including twelve nearly complete genomes and nine partial genomes) in samples derived from rodents, bats, opossums, birds and cattle in Pernambuco, São Paulo, Paraná and Rio Grande do Sul states. These sequences were investigated using phylogenetic and distance-based approaches and were thereby classified into eight parvovirus species (six of which have not been described previously), representing six distinct genera in the subfamily Parvovirinae. Our findings extend the known biogeographic range of previously characterized parvovirus species and the known host range of three parvovirus genera (Dependovirus, Aveparvovirus and Tetraparvovirus). Moreover, our investigation provides a window into the ecological dynamics of parvovirus infections in vertebrates, revealing that many parvovirus genera contain well-defined sub-lineages that circulate widely throughout the world within particular taxonomic groups of hosts.

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Phylogenetic characterization of the first Ungulate tetraparvovirus 2 detected in pigs in Brazil

Cited by 10 publications

References 18 publications

A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials

A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials

Human parvovirus 4 ‘PARV4’ remains elusive despite a decade of study

Novel Parvoviruses from Wild and Domestic Animals in Brazil Provide New Insights into Parvovirus Distribution and Diversity

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