Topical Oxygen Jet Therapy (TOJT) for treating infected chronic surgical wounds

Otaviano, Maria Helena; Salles, Mauro José Costa; Ching, Ting Hui; Dettoni, Josilene Lopes; Coulibaly, Ieda Guedes Simões; Fukunaga, Erika Tiemi; Gamba, Mônica Antar; Moraes, José Cássio de

doi:10.1016/j.bjid.2021.101547

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…Although these devices vary considerably from mechanism to operation method, they can effectively promote diabetic wound healing to some extent [ 52 , 53 ]. Interestingly, a previous report found that direct jetting of gaseous oxygen to infected wound sites at a specific frequency could promote healing [ 54 ]. The processes occurring in TOT are similar to those in the whole-body treatment, causing the intensification of oxygen diffusion and increased oxygen partial pressure in the tissues due to hydration.…”

Section: Chronic Wounds and Oxygenmentioning

confidence: 99%

Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect

Chang

2023

Materials Today Bio

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Section: Chronic Wounds and Oxygenmentioning

confidence: 99%

Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect

Chang

2023

Materials Today Bio

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“…Topical oxygen therapy was delivered in other modes such as oxygen jet, 47 oxygen mist, 48 topical oxygen therapy on the basis of negative‐pressure wound therapy with the use of a micro‐oxygen therapy instrument, 49 and an unspecified topical oxygen therapy delivered at 3–15 mL/h 50 (Tang et al 2020). Results from two RCTs 47 , 49 showed that the TOT treatment group had improved pressure ulcer scale for healing (PUSH) scores compared to the control group (both p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…The number of recent studies published within the last 5 years would imply that topical oxygen therapies for wound healing are becoming an area of interest. Findings from this scoping review show that TOTs have been used in various mode of administration (as shown in Figure 2), and indicate that there is a growing evidence of the effectiveness of TOT as an adjunctive modality for wound healing, especially in diabetic foot ulcers although recent studies show promising results of using TOT for treating pressure ulcers, 30,36 infected surgical wounds, 47 chronic traumatic wounds, 49 skin graft sites 41 and venous leg ulcers 46 although this study should be interpreted with caution as no comparison of the difference between the treatment and control group is offered. There was a variety of included studies from controlled to observational study designs in the included meta‐analyses and systematic reviews which makes comparison challenging.…”

Section: Discussionmentioning

confidence: 99%

Topical oxygen therapy and singlet oxygen in wound healing: A scoping review

Sýkorová,

Moffatt,

Stentiford

et al. 2024

International Wound Journal

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The aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under‐researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10 years (2013–2023) with 32 (65.3%) published in the past 5 years (2018–2023). Eight of the studies were systematic reviews and/or meta‐analysis and 18 were RCTs. The search identified zero human RCTs on singlet oxygen, but one human cohort study and five studies in animals. There is evidence that topical oxygen therapy may be useful for the treatment of chronic wounds, mainly diabetic foot ulcers. Singlet oxygen has shown potential, but would need further confirmation in controlled human trials, including more research to understand the bio‐properties.

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“…Ye et al's study indicated that the application of continuous double negative pressure drainage with micro‐pressure sealing after pressure ulcer skin flap repair effectively promotes skin flap healing, reduces the incidence of distal skin flap necrosis and incision rupture and decreases the occurrence of related complications 27 . Otaviano et al 28 highlighted the benefits of local oxygen therapy in promoting wound healing, reducing pain, improving clinical conditions and reducing the incidence of complications. Local oxygen therapy has also been shown to effectively decrease complication rates in patients with diabetes foot ulcers.…”

Section: Discussionmentioning

confidence: 99%

Effect of local oxygen therapy combined with vacuum sealing drainage on the healing of stage IV sacrococcygeal pressure ulcers

Zhao

Zhang

et al. 2023

International Wound Journal

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The present study aimed to investigate the effect of local oxygen therapy combined with vacuum sealing drainage (VSD) on the healing of stage IV pressure ulcers sacrococcygeal. In this prospective study, we included a total of 98 patients with stage IV sacrococcygeal pressure ulcers in our hospital between February 2021 and June 2022. The patients enrolled were randomly and equally divided into two groups: the study group (undergoing local oxygen therapy combined with VSD treatment) and the control group (receiving conventional treatment). The wound healing time and hospital stay were compared between the two groups. Additionally, the wound area, tissue type, wound exudation and pain intensity were assessed before treatment, 10, 20, 30 and 40 days after treatment. The incidence of complications was also calculated. The study group demonstrated significantly shorter wound healing time and hospital stays compared to the control group (p < 0.05). Before treatment, there were no significant differences in terms of wound area, tissue type and wound exudation between the two groups (p > 0.05); after 10, 20, 30 and 40 days of treatment, however, evidently smaller wound areas, improved tissue types and reduced wound exudation were observed in the study group compared to the control group (p < 0.05). Furthermore, the study group exhibited increased microvascular count compared to the control group (p < 0.05). Before treatment, there was no significant difference in pain intensity between the two groups (p > 0.05), whereas markedly lower pain intensity was seen in the study group than in the control group after 10, 20, 30 and 40 days of treatment (p < 0.05). The incidence of complications did not significantly differ between the two groups after 40 days of treatment (p > 0.05). Local oxygen therapy combined with VSD was found to effectively accelerate the healing process of stage IV sacrococcygeal pressure ulcers, leading to shorter hospital stays and improved patient prognosis. This combined therapy shows promise for widespread application in clinical practice.

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Topical Oxygen Jet Therapy (TOJT) for treating infected chronic surgical wounds

Cited by 9 publications

References 18 publications

Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect

Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect

Topical oxygen therapy and singlet oxygen in wound healing: A scoping review

Effect of local oxygen therapy combined with vacuum sealing drainage on the healing of stage IV sacrococcygeal pressure ulcers

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