Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect

He, Ya‐Ling; Chang, Qiang; Lu, Feng

doi:10.1016/j.mtbio.2023.100687

Cited by 8 publications

(8 citation statements)

References 129 publications

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“…To explore the nature of the observed cellular infiltration in the wounds treated with PD123319 or C21, we analyzed the expression of various immune cell markers and chemoattractant-encoding genes. The gene C-C motif chemokine ligand 2 ( Ccl2 ) encodes monocyte chemoattractant protein (MCP) [ 38 , 39 , 40 ] and was found to be upregulated by both C21 and PD123319 at day 10, with the upregulation noted to be greater with the latter ( Figure 6 K). Cxcl1 encodes C-X-C motif chemokine ligand 1 (CXCL1), which has well-documented roles in inflammation, angiogenesis, and wound healing, including serving as a chemoattractant for neutrophils [ 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…The gene C-C motif chemokine ligand 2 ( Ccl2 ) encodes monocyte chemoattractant protein (MCP) [ 38 , 39 , 40 ] and was found to be upregulated by both C21 and PD123319 at day 10, with the upregulation noted to be greater with the latter ( Figure 6 K). Cxcl1 encodes C-X-C motif chemokine ligand 1 (CXCL1), which has well-documented roles in inflammation, angiogenesis, and wound healing, including serving as a chemoattractant for neutrophils [ 40 , 41 ]. It was downregulated in C21-treated wounds at day 7 and significantly upregulated at day 10 in PD123319-treated wounds ( Figure 6 L).…”

Section: Resultsmentioning

confidence: 99%

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AT2R Activation Improves Wound Healing in a Preclinical Mouse Model

Harrison,

Leong,

Osborne

et al. 2024

Biomedicines

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Abnormal skin healing resulting in chronic wounds or hypertrophic scarring remains a major healthcare burden. Here, the antifibrotic angiotensin II type 2 receptor (AT2R) signaling pathway was modulated to determine its impact on cutaneous wound healing. Balb/c mice received two splinted full-thickness wounds. Topical treatments with the selective AT2R agonist compound 21 (C21) and/or selective antagonist PD123319 or saline vehicle were administered until sacrifice on post-wounding days 7 or 10. The rate of wound re-epithelialization was accelerated by PD123319 and combination treatments. In vitro, C21 significantly reduced human fibroblast migration. C21 increased both collagen and vascular densities at days 7 and 10 post-wounding and collagen I:III ratio at day 10, while PD123319 and combination treatments decreased them. Genes associated with regeneration and repair were upregulated by C21, while PD123319 treatment increased the expression of genes associated with inflammation and immune cell chemotaxis. C21 treatment reduced wound total leukocyte and neutrophil staining densities, while PD123319 increased these and macrophage densities. Overall, AT2R activation with C21 yields wounds that mature more quickly with structural, cellular, and gene expression profiles more closely approximating unwounded skin. These findings support AT2R signal modulation as a potential therapeutic target to improve skin quality during wound healing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

AT2R Activation Improves Wound Healing in a Preclinical Mouse Model

Harrison,

Leong,

Osborne

et al. 2024

Biomedicines

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“…At the same time, the increase in metabolism in the wound area greatly increases the demand for O 2 , further exacerbating tissue cell hypoxia. 53 Although acute hypoxia early in skin injury can stimulate hypoxia inducible factor-1a (HIF-1a) production and promote angiogenesis, chronic hypoxia not only impedes angiogenesis but also impedes energy production and cellular metabolism. 54,55 Therefore, hypoxia is also a problem that needs to be addressed in diabetic wound healing.…”

Section: Diabetes Affects Normal Wound Healingmentioning

confidence: 99%

Recent advances of hydrogels as smart dressings for diabetic wounds

Wang,

Yang,

Zhao

et al. 2024

J. Mater. Chem. B

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“…The ideal dressing can protect a wound from secondary injury, form a suitable tissue repair microenvironment, and support cell growth and wound healing. There are various types of dressings, such as hydrogels, microspheres [ 62 ] and scaffolds [ 63 ]. Hydrogels are a 3D porous carrier with excellent absorption capacity and oxygen permeability.…”

Section: Reviewmentioning

confidence: 99%

Hypoxic environment of wounds and photosynthesis-based oxygen therapy

Tian,

Tan,

Fan

et al. 2024

Burns &Amp; Trauma

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The hypoxic environment is among the most important factors that complicates the healing of chronic wounds, such as venous leg ulcers, pressure injuries and diabetic foot ulcers, which seriously affects the quality of life of patients. Various oxygen supply treatments are used in clinical practice to improve the hypoxic environment at the wound site. However, problems still occur, such as insufficient oxygen supply, short oxygen infusion time and potential biosafety risks. In recent years, artificial photosynthetic systems have become a research hotspot in the fields of materials and energy. Photosynthesis is expected to improve the oxygen level at wound sites and promote wound healing because the method provides a continuous oxygen supply and has good biosafety. In this paper, oxygen treatment methods for wounds are reviewed, and the oxygen supply principle and construction of artificial photosynthesis systems are described. Finally, research progress on the photosynthetic oxygen production system to promote wound healing is summarized.

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Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect

Cited by 8 publications

References 129 publications

AT2R Activation Improves Wound Healing in a Preclinical Mouse Model

AT2R Activation Improves Wound Healing in a Preclinical Mouse Model

Recent advances of hydrogels as smart dressings for diabetic wounds

Hypoxic environment of wounds and photosynthesis-based oxygen therapy

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