Clinical and epidemiological aspects of Candidemia in eight medical centers in the state of Parana, Brazil: Parana Candidemia Network

Oliveira, Carla Sakuma de; Colombo, Arnaldo Lopes; Francisco, Elaine Cristina; Lima, Bernardo de; Gandra, Rinaldo Ferreira; Carvalho, Mariza Cristina Preifz de; Carrilho, Cláudia Maria Dantas de Maia; Petinelli, Renan Pontes; Pelison, Marsilene; Helbel, César; Czelusniak, Gerson; Morales, Hugo Manuel Paz; Perozin, Jamile Sardi; Pinheiro, Rosângela Lameira; Cognialli, Regielly Caroline Raimundo; Breda, G; Queiroz‐Telles, Flávio

doi:10.1016/j.bjid.2020.11.006

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…Therefore, they may underreport cases of hospitalisation for IFIs in Paraná. However, the data corroborate the literature available in Brazil and in the state, giving more certainty to the analysed data [3, 6, 9, 10, 24]. The OLS model did not allow a local analysis of the variables, but this model, despite not providing local maps, is well consolidated and accepted in different studies and does not affect our analyses [32, 33].…”

Section: Discussionsupporting

confidence: 81%

“…However, a review of histoplasmosis cases in Brazil observed that the State of Paran a has 10%-20% of positivity in skin tests for Histoplasma capsulatum [8]. In addition to endemic infections, other fungal infections have been reported in the state, such as invasive aspergillosis with an incidence of 3.9 cases per 10,000 hospitalisations in a given hospital in the region and candidemia with an incidence of 2.7 cases per 1000 hospitalisations [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Impact of invasive fungal infections in men from a state in southern Brazil: A geospatial analysis

Ferreira

Gadêlha

Vissoci

et al. 2023

Tropical Med Int Health

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ObjectiveTo analyse the records of male hospitalisation for fungal infections, including their spatial distribution and the main invasive epidemiological and sociodemographic characteristics in the State of Paraná, Brazil.MethodsSpatial analysis based on data from male admission records for invasive fungal infections (IFIs) in the State of Paraná, from 2015 to 2019. Data were taken from the hospital records obtained in the Hospital Information System of the Unified Health System, being collected, georeferenced and analysed to infer the existence of autocorrelation with the hospitalisation rates in the state.ResultsFrom 2015 to 2019, there were 385 cases of IFIs in men, being more prevalent in white individuals aged 61–70 years. We observed that the metropolitan, southeast, central‐eastern, north‐central, northwestern and western regions formed high–high clusters, with regions with a high number of registered cases. In the regression, there was an association with socioeconomic and demographic factors that showed a correlation with the rates of hospitalisation for IFIs.ConclusionThe study draws attention to Paraná as an endemic region for paracoccidioidomycosis, in addition to presenting high rates of nosocomial fungal infections. We also emphasise the importance of compulsory notification in the state and in the country to gain greater control over the incidence and prevalence of cases and to incentivise the creation of public policies for the prevention of IFIs.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Impact of invasive fungal infections in men from a state in southern Brazil: A geospatial analysis

Ferreira

Gadêlha

Vissoci

et al. 2023

Tropical Med Int Health

View full text Add to dashboard Cite

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“…Similar increases have been reported in Turkey and other countries throughout the years. For instance, studies reported that the incidence of candidemia episodes increased from 0.21 to 0.51 in Australia (10,11), from 0.2-0.38 to 0.83 in European countries (6,12), from 0.74 to 1.2-1.3 in Brazil (13,14), and only in three years from 0.47 to 0.69 in Croatia (15). Although there has been a global rise throughout the years, our rates are still higher than the whole incidence (6,12).…”

Section: Discussionmentioning

confidence: 99%

Ophthalmologic Examination and Echocardiography Should be the Essential Components of Candidemia Bundle

Erol

Sarı

Senol

et al. 2023

Infect Dis Clin Microbiol

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Objective: Candidemia is the most common form of invasive candidiasis, and it is associated with end-organ involvement, prolonged hospitalization, increased mortality, and higher healthcare costs. Candidemia can lead to metastatic heart and ocular infections. This study aimed to define the incidence, characteristics, and mortality of candidemia episodes and compare the data with our center’s previous results. Materials and Methods: In this single-center retrospective observational study, we enrolled 250 patients over 18 years diagnosed with candidemia between January 2015 and December 2020. We obtained patients’ demographic, clinical, laboratory, and therapeutic data from medical records. An ophthalmologic examination and screening with echocardiography were carried out within the first week after candidemia diagnosis. Results: There were 275 candidemia episodes from 250 patients. The incidence of candidemia was 2.8/1000 admissions and 5.68/ 10,000 inpatient days, higher than our previous results (1.23/1000 and 3.29/10,000). The median age was 65 (interquartile range [IQR]=52-75) years. Malignancies were the most frequent comorbidity (50%). The most common type was Candida albicans (n=115, 41.8%). Candida glabrata (n=61, 22.2%) was common, particularly in surgical patients, patients with malignancy, and critically ill patients. There was Infectious disease consultation in 93.3% (257) episodes. The ophthalmoscopic examination was made in 145 episodes (52.7%), and ophthalmitis was detected in 16 (11.0%). Echocardiography was performed in 139 (50.5%) episodes; one case had an endocarditis diagnosis. The 30-day mortality was 44.7% (n=123). Mortality rates in C. glabrata and Candida krusei infections were higher (54.1% and 66.7). The factors related to mortality were intensive care unit requirement (p=0.0001), chronic liver disease (p=0.005), corticosteroid usage (p=0.0001), previous antibiotic usage (p=0.013), multiple antibiotic usage (p=0.020), and CVC related candidemia (p=0.010). Conclusion: Because of the life-threatening complications such as endocarditis, increased mortality rates, and higher healthcare costs, systematic and comprehensive candidemia bundle applications would be effective strategies for providing an effective antifungal stewardship program. Keywords: Candidemia, mortality, ophthalmitis, endocarditis, bundle

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Can There Be a Relationship Between Oral Candidiasis and Candidemia in ICU Patients?

Ferreira

Silva

Oliveira

et al. 2023

Curr Fungal Infect Rep

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Clinical and epidemiological aspects of Candidemia in eight medical centers in the state of Parana, Brazil: Parana Candidemia Network

Cited by 6 publications

References 48 publications

Impact of invasive fungal infections in men from a state in southern Brazil: A geospatial analysis

Impact of invasive fungal infections in men from a state in southern Brazil: A geospatial analysis

Ophthalmologic Examination and Echocardiography Should be the Essential Components of Candidemia Bundle

Can There Be a Relationship Between Oral Candidiasis and Candidemia in ICU Patients?

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