COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil

Castro, Rodolfo; Luz, Paula M.; Wakimoto, Mayumi Duarte; Veloso, Valdiléa G.; Grinsztejn, Beatriz; Perazzo, Hugo

doi:10.1016/j.bjid.2020.04.003

Cited by 122 publications

(133 citation statements)

References 6 publications

(3 reference statements)

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“…Additional methods, such as serological tests, in which the virus antigens or antibodies produced are investigated, can also confirm the diagnosis 6,7 . Large-scale testing, rapid diagnosis, and immediate case isolation, associated with rigorous screening and preventive measures of social distance, and basic hygiene, are essential procedures to reduce the spread of COVID-19 1,8 .…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with delay in diagnosis and mortality in patients with COVID-19 in the city of Rio de Janeiro, Brazil

Cobre

Böger

Fachi

et al. 2020

Ciênc. saúde coletiva

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We investigated the predictors of delay in the diagnosis and mortality of patients with COVID-19 in Rio de Janeiro, Brazil. A cohort of 3,656 patients were evaluated (Feb-Apr 2020) and patients’ sociodemographic characteristics, and social development index (SDI) were used as determinant factors of diagnosis delays and mortality. Kaplan-Meier survival analyses, time-dependent Cox regression models, and multivariate logistic regression analyses were conducted. The median time from symptoms onset to diagnosis was eight days (interquartile range [IQR] 7.23-8.99 days). Half of the patients recovered during the evaluated period, and 8.3% died. Mortality rates were higher in men. Delays in diagnosis were associated with male gender (p = 0.015) and patients living in low SDI areas (p < 0.001). The age groups statistically associated with death were: 70-79 years, 80-89 years, and 90-99 years. Delays to diagnosis greater than eight days were also risk factors for death. Delays in diagnosis and risk factors for death from COVID-19 were associated with male gender, age under 60 years, and patients living in regions with lower SDI. Delays superior to eight days to diagnosis increased mortality rates.

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Section: Introductionmentioning

confidence: 99%

Risk factors associated with delay in diagnosis and mortality in patients with COVID-19 in the city of Rio de Janeiro, Brazil

Cobre

Böger

Fachi

et al. 2020

Ciênc. saúde coletiva

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“…This was corroborated by a Brazilian study that analyzed the rapid tests available in the country and found them to be efficacious. 30 In this study this was important for laboratory confirmation of C02, C03, C04 and C05.…”

Section: Discussionmentioning

confidence: 95%

Descrição de um cluster da COVID-19: o isolamento e a testagem em assintomáticos como estratégias de prevenção da disseminação local em Mato Grosso, 2020

Silva¹,

Oliveira²,

Hattori³

et al. 2020

Epidemiologia e Serviços de Saúde

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Objective: to describe a COVID-19 cluster and the strategies used to contain the virus, in a municipality in the interior region of Mato Grosso state, Brazil. Methods: this is a descriptive study of documental records of an epidemiological investigation conducted in April 2020. Results: introduction of SARS-CoV-2 in the municipality was identified through a cluster comprised of five people, 4 were symptomatic and 1 was asymptomatic, after the virus was imported by index cases C01 and C02; in addition to household transmission (C03, C04), a physiotherapist (C05) was infected through contact with C02; with the exception of C04, all had an influenza-like symptoms and C02 required hospitalization; as for laboratory tests, all were seroreactive and C01 was RT-PCR positive. Conclusion: dissemination of COVID-19 was contained by effective home isolation, an important instrument that should be adopted early by unaffected municipalities to contain virus dissemination, as well as by serological testing that detected infection in asymptomatic patients.

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“…Hoffman et al (2020) evaluated RDT #3 and found higher speci cities, 100% for IgM and 99.2% for IgG. A meta-analysis of regulatory data from serologic RDTs approved in Brazil found a pooled speci city of 97% for IgM and 98% for IgG (Castro et al, 2020). A study evaluating a RDT in China included 128 "clinical negative samples" and found one sample positive for IgG and 10 positive for IgM (Li et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Using prenatal blood samples to validate COVID-19 rapid serologic tests

Alger

Cafferata

Alvarado³

et al. 2020

Preprint

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IntroductionBackground cross-reactivity with other coronaviruses may reduce the specificity of COVID-19 rapid serologic tests. Blood collected during prenatal care is a unique source of population-based samples appropriate for validation studies. We used stored 2018 serum samples from an existing pregnancy cohort study to evaluate the specificity of COVID-19 serologic rapid diagnostic tests. MethodsWe randomly selected 120 stored serum samples from pregnant women enrolled in a cohort in 2018, at least one year before the COVID-19 pandemic. We used stored serum to evaluate four lateral flow rapid diagnostic tests, following manufacturers’ instructions. Pictures were taken for all tests and read by two blinded trained evaluators. Results We evaluated 120, 80, 90, and 90 samples, respectively. Specificity for both IgM and IgG was 100% for the first two tests. The third test had a specificity of 98.9% for IgM and 94.4% for IgG. The fourth test had a specificity of 88.9% for IgM and 100% for IgG.Discussion COVID-19 serologic rapid tests are of variable specificity. Blood specimens from sentinel prenatal clinics provide an opportunity to validate serologic tests with population-based samples.

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COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil

Cited by 122 publications

References 6 publications

Risk factors associated with delay in diagnosis and mortality in patients with COVID-19 in the city of Rio de Janeiro, Brazil

Risk factors associated with delay in diagnosis and mortality in patients with COVID-19 in the city of Rio de Janeiro, Brazil

Descrição de um cluster da COVID-19: o isolamento e a testagem em assintomáticos como estratégias de prevenção da disseminação local em Mato Grosso, 2020

Using prenatal blood samples to validate COVID-19 rapid serologic tests

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