Bloodstream infection by mcr-1-harboring Escherichia coli in a cancer patient in southern Brazil

Lorenzoni, Vinícius Victor; Dalmolin, Tanise Vendruscolo; Franco, Laísa Nunes; Barth, Afonso Luís; Hörner, Rosmari

doi:10.1016/j.bjid.2018.07.001

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…This sample was collected in September 2017 in Rio Grande do Sul from a female patient with malignant neoplasm. Resistance to colistin was verified by Broth Microdilution (BMD) [69]. And another retrospective study in 2018 was the first known report in Brazil of S. enterica serovar Schwarzengrund harboring the mcr-1 gene in Sa ˜o Paulo city isolated from chicken cuts between 2013 and 2016 [70].…”

Section: Brazilmentioning

confidence: 99%

mcr-mediated colistin resistance in South America, a One Health approach: a review

Daza-Cardona

Buenhombre

Fontenelle

et al. 2021

Reviews in Medical Microbiology

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Antimicrobial resistance is recognized as one of the most important global human health problems in the 21st century. The balance between clinical need and resistance prevention is further compromised by agricultural antibiotic use as some countries have actively used colistin in animal production. Antimicrobial-resistant microorganisms have been found in humans, food, animals, plants, and the environment (water, soil, and air), and they can move between ecosystems. The problem of antimicrobial resistance is currently seen in the concept: One Health. This approach encourages interdisciplinary collaborative efforts that work locally. The beginnings of the mcr gene's presence in America dates to 2012 and the first report of disseminating the mcr-1 gene was described for Kelp gulls (Larus dominicanus) from Ushuaia, Argentina. It can be associated with the possible dissemination of the gene in the American continent through migratory birds. The mcr-1 gene is disseminated in countries, such as Argentina,

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Section: Brazilmentioning

confidence: 99%

mcr-mediated colistin resistance in South America, a One Health approach: a review

Daza-Cardona

Buenhombre

Fontenelle

et al. 2021

Reviews in Medical Microbiology

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“…mcr-1 has been sporadically described among human clinical isolates with multidrug resistance profiles (MDR; Fernandes et al, 2016 ; Aires et al, 2017 ; Conceição-Neto et al, 2017 ; Dalmolin et al, 2017 , 2018 ; Rocha et al, 2017 ; Lorenzoni et al, 2018 ; Oliveira et al, 2018 ; Tada et al, 2018 ; Tonini et al, 2018 ; Farzana et al, 2019 ). However, the most frequently reported detection of mcr-1 is in environmental and food-animal strains.…”

Section: Discussionmentioning

confidence: 99%

Genomic Characterization of mcr-1.1-Producing Escherichia coli Recovered From Human Infections in São Paulo, Brazil

et al. 2021

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Polymyxins are one of most important antibiotics available for multidrug-resistant Gram-negative infections. Diverse chromosomal resistance mechanisms have been described, but the polymyxin resistance phenotype is not yet completely understood. The objective of this study was to characterize colistin resistant mcr-1-producing strains isolated from human infections over one year in a hospital setting (Hospital das Clínicas, São Paulo, Brazil). We isolated 490 colistin-resistant Gram-negative rods, of which eight were mcr-1.1-positive Escherichia coli, the only species with this result, indicating a low incidence of the mcr-1 production mechanism among colistin-resistant isolates. All mcr-1.1 positive isolates showed similarly low MICs for colistin and were susceptible to most antibiotics tested. The isolates showed diversity of MLST classification. The eight mcr-1.1-positive E. coli genomes were sequenced. In seven of eight isolates the mcr-1.1 gene is located in a contig that is presumed to be a part of an IncX4 plasmid; in one isolate, it is located in a contig that is presumed to be part of an IncHI2A plasmid. Three different genomic contexts for mcr-1.1 were observed, including a genomic cassette mcr-1.1-pap2 disrupting a DUF2806 domain-containing gene in six isolates. In addition, an IS1-family transposase was found inserted next to the mcr-1.1 cassette in one isolate. An mcr-1.1-pap2 genomic cassette not disrupting any gene was identified in another isolate. Our results suggest that plasmid dissemination of hospital-resident strains took place during the study period and highlight the need for continued genomic surveillance.

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“…The frequency of mcr-1 was found to be 20% in animal bacterial strains and 1% in human bacteria in China 23 . A few months after being reported for the first time, mcr-1 has been detected in bacterial isolates from animals, humans, and the environment in various countries in South America, North America, Europe, Asia, and Africa, and has been identified in several bacterial genera, including Escherichia, Shigella, Klebsiella, Salmonella, Enterobacter, and E. coli [31][32][33][34][35] .…”

Section: Mechanisms Of Polymyxin Resistancementioning

confidence: 99%

Overview of polymyxin resistance in Enterobacteriaceae

Silva

Rossato

Leite

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.

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Bloodstream infection by mcr-1-harboring Escherichia coli in a cancer patient in southern Brazil

Cited by 6 publications

References 5 publications

mcr-mediated colistin resistance in South America, a One Health approach: a review

mcr-mediated colistin resistance in South America, a One Health approach: a review

Genomic Characterization of mcr-1.1-Producing Escherichia coli Recovered From Human Infections in São Paulo, Brazil

Overview of polymyxin resistance in Enterobacteriaceae

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