Humoral immune response to measles and varicella vaccination in former very low birth weight preterm infants

Ferreira, Carolina Schlindwein Mariano; Perin, Maria Cristina Abrão Aued; Moraes-Pinto, Maria Isabel de; Simão-Gurge, Raquel Maria; Goulart, Ana Lúcia; Weckx, Lily Yin; Santos, Amélia Miyashiro Nunes dos

doi:10.1016/j.bjid.2017.12.001

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…A prospective study by Ferreira et al compared the immune response to measles and varicella vaccination in infants born prematurely with those born full-term. The proportion of infants with protective humoral titers to measles and varicella after vaccination were similar in both groups[64].…”

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confidence: 78%

“…When a cardiorespiratory AE to the first dose is suspected, consideration should be given to administering the second vaccination under controlled circumstances. Considering immunogenicity, the proportion of PIs who developed humoral immunity were generally similar in preterm compared with full term infants for many vaccines, with contrasting results for PCV vaccines, even if PCV7 effectiveness was found to be high in preterm infants in one study [64,66,73]. Good seroprotection rate for Hib, MenC, HBV, influenza and IPV vaccinations were reported in PIs [47,48,50,53,72], even if lower gestational ages were associated to lower GMCs in most of the studies and for most valences (i.e.…”

Section: Accepted Manuscriptmentioning

confidence: 96%

“…Live attenuated vaccines were investigated in 6 studies [41,42,45,46,63,64]. [31,49,54,65,66,67], while the assessment of the PCV effectiveness was the aim of one study [68].…”

Section: 21-studies On Live Attenuated Vaccines' Immunogenicity and E...mentioning

confidence: 99%

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Update on vaccination of preterm infants: a systematic review about safety and efficacy/effectiveness. Proposal for a position statement by Italian Society of Pediatric Allergology and Immunology jointly with the Italian Society of Neonatology.

Chiappini

Petrolini

Sandini

et al. 2019

Expert Review of Vaccines

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Introduction: Preterm infants (PIs) are at increased risk of vaccine preventable diseases (VPDs). However delayed vaccination start and low vaccine coverage are still reported. Areas covered: This systematic review includes 37 articles on preterm vaccination published in 2008-2018 in PubMed. Both live attenuated and inactivated vaccines are safe and well tolerated in PIs. Local reactions, apnea and reactivity changes are the most frequently reported adverse events. Lower gestational age and birth weight, preimmunization apnea, longer use of continuous positive airway pressure (CPAP) are risk factor for apnea. The proportion of PIs who develop protective humoral and cellular immunity is generally similar to full terms although later gestational age is associated to increased antibody IgG concentrations (i.e. against certain pneumococcal serotypes, influenza, hepatitis B virus and poliovirus 1) and increased mononuclear cells proliferation (i.e. after inactivated poliovirus). However vaccinated PIs have lower hospitalizations, ambulatory visits and notifications of VPDs. Expert opinion: PIs can be safely and adequately protected by available vaccines with the same schedule used for full terms. However data at this regard have been almost exclusively retrieved by studies using a 3dose primary series for pneumococcal and hexavalent vaccines, while further studies are needed regarding the 2+1 schedule. Apnea represents a nonspecific stress response in PIs, thus those hospitalized at 2 months should have cardio-respiratory monitoring for 2 days after their first vaccination.

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confidence: 78%

Section: Accepted Manuscriptmentioning

confidence: 96%

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Update on vaccination of preterm infants: a systematic review about safety and efficacy/effectiveness. Proposal for a position statement by Italian Society of Pediatric Allergology and Immunology jointly with the Italian Society of Neonatology.

Chiappini

Petrolini

Sandini

et al. 2019

Expert Review of Vaccines

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“…Another factor, breastfeeding was previously proposed to be support according to the significant influence for several vaccine during infancy ( 28 ). Humoral response to measles was positively correlated with longer breastfeeding period ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Nurlatifah¹,

Barlıanto²,

Wiyasa³

et al. 2021

Med Arch

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Background: Measles outbreaks under high coverage of measles vaccination in Indonesia is gaining a necessary evaluation of factors associated with measles-vaccine immune responses. Objctive: The purposes of recent study were to evaluate the association of sociodemographic and anthropometric parameters and specific immune responses towards first dose Edmonston-Zagreb (EZ) measles vaccine in Indonesian infants. Methods: A total of 35 infants were enrolled in this cohort study. Measles immune responses were followed up at one and six months after vaccination then analyzed for its association with sociodemographic, anthropometric, and nutritional parameters. The plaque-reduction microneutralization assay was conducted to measure the titer of measles specific IgG antibody. The level of CD4 + and CD8 + T-cells that exhibiting gamma interferon (IFN-γ) secretion were analyzed by flow cytometry. The association between variable was analyzed by linear regression. The difference immune response among variable were analyzed with Mann-Whitney test. Results: Vitamin A supplementation and breastfeeding were predicted as associated factor for humoral and cellular immune response after one month and six months measles vaccination among Indonesia Infants. Conclusion: Nutritional factor is associated with measles vaccination immune response in Indonesian infants.

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“…This study shows that the seroprevalence is significantly higher in girls than in boys, and the reported incidence rate is lower in girls than in boys. The reasons for this finding may be complicated and may include the different contact rate, different exposure levels and different asymptomatic infection rate of these children [ 21 , 22 ]. By contrast, a German study showed that there was no difference between boys and girls, which may indicate cultural differences, and in-depth reasons for this discrepancy should be further explored [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of sero-epidemiological characteristics of varicella in healthy children in Jiangsu Province, China

Zhang

Liu

et al. 2018

BMC Infect Dis

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BackgroundIn recent years, outbreaks of varicella have continued to occur, and the coverage rate of varicella vaccine in Jiangsu Province, China, remains unclear. This study aims to analyse the levels of immune antibody against varicella and obtain a comprehensive understanding of the varicella attenuated live vaccine (VarV) coverage rate in children aged 1–9 years in Jiangsu Province.MethodsFrom June to October 2016, a cross-sectional survey was conducted to collect 3631 serum samples from healthy children aged 1–9 years in Jiangsu Province. The immunoglobulin G (IgG) antibody levels of varicella were detected by enzyme-linked immunosorbent assay (ELISA).ResultsThe VarV coverage rate of healthy children was only 43.1% (95% CI: 41.1–44.7%). The seroprevalence after vaccination with a single dose of VarV was only 57.1%, and the overall seropositivity and geometric antibody titre (GMC) were 43.5% and 225.4 mU/ml, respectively. The seropositivity was significantly higher in girls than in boys (χ2 = 18.82, P < 0.001). The difference in seropositivity between the 5–9 age group and 1–4 age group was statistically significant (χ2 = 84.31, P < 0.001). The difference in seropositivity between different regions was statistically significant, with the highest seropositivity in the northern area, 53.7% (χ2 = 35.64, P < 0.001). The seropositivity in the group receiving one dose of VarV was significantly higher than that of the unvaccinated group (χ2 = 205.16, P < 0.001). Linear regression analysis suggested that the GMC of varicella antibodies wanes with the time since vaccination (F = 65.01, P = 0.002).ConclusionThe VarV coverage rate of healthy children in Jiangsu Province was low. Sero-conversion rates were also low after one dose of VarV, and the immune effectiveness of a single dose of VarV was limited. To control the spread of varicella, VarV should be included in the routine immunization program, and strengthened immunization measures for the varicella-susceptible population warrant additional consideration.

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Humoral immune response to measles and varicella vaccination in former very low birth weight preterm infants

Abstract: Humoral responses to measles and varicella were similar between infants born prematurely and full-term infants. Measles antibody levels were negatively associated with antenatal corticosteroid use; varicella antibodies were positively associated with prolonged breastfeeding.

Cited by 5 publications

References 24 publications

Update on vaccination of preterm infants: a systematic review about safety and efficacy/effectiveness. Proposal for a position statement by Italian Society of Pediatric Allergology and Immunology jointly with the Italian Society of Neonatology.

Update on vaccination of preterm infants: a systematic review about safety and efficacy/effectiveness. Proposal for a position statement by Italian Society of Pediatric Allergology and Immunology jointly with the Italian Society of Neonatology.

Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Analysis of sero-epidemiological characteristics of varicella in healthy children in Jiangsu Province, China

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