Unrecognized pediatric and adult family members of children with acute brucellosis

Çiftdoğan, Dilek Yılmaz; Aslan, Selda

doi:10.1016/j.bjid.2017.05.006

Cited by 8 publications

(12 citation statements)

References 14 publications

(22 reference statements)

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“…Due to the common living area and the common food consumption, the risk of Brucella is increased in family members of index case family members. In previous studies, with the scanning of family members, the seropositivity rate was reported as 9.5% -36.8% and it was suggested that family members should be examined for Brucella [16,17]. In our study, brucella history rate of patients' family members was found to be 39.2%.…”

Section: Discussionsupporting

confidence: 50%

Brucella infection in children: Evaluation of 148 pediatric patients

2019

Ann Clin Anal Med

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Aim: Brucellosis a worldwide infectious zoonotic disease. This study was aimed to evaluate the clinical, demographic characteristics, complications, treatment and follow-up results of pediatric patients diagnosed with brucellosis. Material and Method: The medical records of 148 pediatric patients who were diagnosed with brucellosis were studied retrospectively. Results: Sixty-one female (41.2%), 87 male (58.8%), in total 148 pediatric patients who were diagnosed with brucellosis were included in the study. Among the patients, 64.1% had a history of consuming fresh cheese, 4.1% had a history of consuming raw milk and 16.9% had a history of keeping a Brucella diagnosed animal at home. Brucella history rate in the family members of the patients was determined as 39.2%; and 12.8% of the patients included in the study were asymptomatic. The most common complaint of the patients who were symptomatic was fever (59.5%) followed by arthralgias (41.2%) and leg pain (38.5%). All patients were subjected to standard tube agglutination test and blood culture was taken from 93 patients. B. melitensis in blood culture was positive in 72% of the patients. Osteoarticular involvement developed in 12.1% of the patients; and 1.3% of the patients developed relapses after the end of the treatment. Discussion: Brucellosis is still an endemic disease in Turkey. Brucella can infect all organs and tissues and is a major cause of morbidity. The use of more than one antibiotic in the treatment and long treatment duration reduces patient compliance; thus, close follow-up of the patients is important.

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Section: Discussionsupporting

confidence: 50%

Brucella infection in children: Evaluation of 148 pediatric patients

2019

Ann Clin Anal Med

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“…Brucellosis confronts public health currently as a widespread problem all over the world and it is especially common in the Middle East including Turkey [1][2]. The incidence of this zoonotic disease in Turkey is around 23-25 per 100,000 annually [1,3]. Brucellosis is frequent in the rural areas of Turkey, especially in Central and Southeastern Anatolia, where animal husbandry is common.…”

Section: Introductionmentioning

confidence: 99%

“…Brucellosis is frequent in the rural areas of Turkey, especially in Central and Southeastern Anatolia, where animal husbandry is common. Among the causative strains, Brucella melitensis is the most commonly isolated strain [1,3].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Sensitivity and Specificity of Laboratory Tests Used in Differential Diagnosis of Childhood Brucellosis

Kazanasmaz¹,

Geter

2020

Cureus

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Childhood brucellosis is a common public health problem in developing countries. The diagnosis of brucellosis based on nonspecific symptoms is an ongoing problem for physicians, especially in endemic areas. In this study, it is aimed to discuss the efficacy of frequently used test methods in the differential diagnosis of brucellosis. Methods The records of 332 patients admitted to pediatric clinic on suspicion of brucellosis were retrospectively analyzed. Patients with brucellosis were included in the positive group (n = 262) and those without brucellosis were included in the negative group (n = 70). Results As a result of biochemical analysis of the cases, median alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), erythrocyte sedimentation rate (ESR), and C reactive protein (CRP) values were significantly higher in the positive group than that in the negative group (p<0.05). There was no significant difference between median white blood cell, neutrophil, lymphocyte, neutrophil to lymphocyte ratio, hemoglobin, and platelet values between groups (p>0.05). Receiver operating curves were plotted to compare predictive values of CRP (area under curve (AUC): 0.635, p= 0.001), ESR(AUC:0.701, p<0.001), AST(AUC: 0.595, p=0.015), ALT(AUC:0.604, p=0.007), and GGT(AUC:0.593, p=0.016) in 332 patients with suspected brucellosis. Conclusions Increased levels of AST, ALT, GGT, CRP, and ESR may have a complementary role in the differential diagnosis of childhood brucellosis. However, all of these markers should be evaluated with clinical findings due to their low specificity and sensitivity.

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“…Direct contact with infected animal is a possible acquision route of infection in older children whose families are engaged in animal husbandry. 1,13 The majority of our patients had a history for consumption of unpasteurized milk, suggesting that this was the most common route of acquisition in this setting. Although human to human transmission is rare, cases of neonatal infection have raised the possibility of transplacental transmission.…”

Section: Discussionmentioning

confidence: 95%

Clinicoepidemiological findings of childhood brucellosis in a tertiary care center in Central Anatolia: with the emphasis of hematological findings

Kaman¹,

Öz²,

Fettah³

et al. 2022

Turk J Pediatr

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Human brucellosis is one of the most widespread zoonotic diseases and a public health problem in many countries of the Mediterranean and Middle East where bovine brucellosis has not been controlled. It can affect people at any age including children. Approximately 20-30% of cases are diagnosed during childhood. [1][2][3] Humans can acquire infections via consumption of infected unpasteurized milk and milk products or direct contact with infected animals, secretions and carcasses. Brucellosis is a multisystemic disease which can be presented with various non-specific clinical signs. The most common clinical manifestations include arthralgia, fever, sweating, weight loss, fatigue, and anorexia. 1 Some of these

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Unrecognized pediatric and adult family members of children with acute brucellosis

Abstract: The routine screening of both pediatric and adult family members of index cases is a priority in endemic areas. Using this screening approach, unrecognized family members who are seropositive for brucellosis will be identified earlier and be able to receive prompt treatment.

Cited by 8 publications

References 14 publications

Brucella infection in children: Evaluation of 148 pediatric patients

Brucella infection in children: Evaluation of 148 pediatric patients

Investigation of the Sensitivity and Specificity of Laboratory Tests Used in Differential Diagnosis of Childhood Brucellosis

Clinicoepidemiological findings of childhood brucellosis in a tertiary care center in Central Anatolia: with the emphasis of hematological findings

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