A strange infiltrative plaque on the face

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Leishmaniasis is world-wide one of the most common infectious disorders caused by protozoa. Due to the climate change, there is a risk of further spread of the disease to central and northern Europe. Another important issue is the high number of refugees from Syria since Syria is one of the hot spots of Old World leishmaniasis. We report on single-centre experience with leishmaniasis in the capital of Saxony, Dresden, during the years 2001 to 2017. We noted a substantial increase in the last five years. Once a very rare exotic disorder in Germany, cutaneous leishmaniasis has become a reality and physicians should be aware of it. A significant number of cases are from Syrian refugees; other cases had been acquired by tourists in the Mediterranean region!

“…In Aleppo and the surrounding northern area of Syria, L. major is the major pathogen [ 11 ]. L. infantum is the dominant species in Sicily [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Leishmaniasis – A Case Series from Dresden

Wollina¹,

Koch²,

Guarneri³

et al. 2018

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“…Among infectious disorders, cutaneous leishmaniasis is emerging in non-epidemic areas. The disease is caused by vector-borne protozoal cutaneous infection by several species of Leishmania transmitted by sandflies [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Evolving Unilateral Indurated Oozing Facial Plaques in a Patient with Head-and-Neck Cancer: Peripheral T-Cell Lymphoma Not Otherwise Specified (NOS)

Wollina¹,

Hansel²,

Langner³

et al. 2017

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BACKGROUNDThe sudden development of facial plaques and nodules may be an alarming clinical sign for underlying malignancies. Nevertheless, a broad range of inflammatory and infectious diseases must be considered as well in the differential diagnosis.CASE REPORTWe report on a 53-year-old male patient with a left-sided cheek infiltration with oozing but no lymphadenopathy. He had a medical history of head-and-neck cancer. The primary differential diagnosis was herpes zoster with secondary impetiginization or pyoderma facial. About eight weeks later, the patient presented with progressive formation of nodules and plaques on the face and isotretinoin was stopped. Skin biopsy suggested mycosis fungoid and an oral treatment with bexarotene was started. After limited response for another eight weeks, he returned later with massive facial swelling, nodules and impetiginization. Another skin biopsy was performed to exclude diagnostic error or investigate possible disease progression. Microscopic evaluation and multiplex-polymerase chain reaction confirmed the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTL-NOS), stage Ia (T1 N0 M0). Imaging techniques excluded metastatic spread. By interdisciplinary tumour board, R-CHOP (rituximab, cyclophosphamide, hydroxyl-doxorubicin, vincristine, and prednisolone) was recommended and initiated by hemato-oncologists.CONCLUSIONSPLT-NOS confirmed in the present patient has a poor prognosis with a 5-year survival rate of less than 20%.

“…Mediterranian basin is an endemic region for several parasitoses [ 18 , 19 ]. Among these, cutaneous leishmaniasis is relatively frequent, mostly due to Leishmania infantum , carried by the female sandflies of Phlebotomus perniciosus [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Hoigne Syndrome Caused by Intralesional Meglumine Antimoniate

Guarneri¹,

Tchernev²,

Wollina³

et al. 2017

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Hoigne syndrome (HS) is the term coined to describe an acute, non-allergic, psychiatrically based reaction occurring with a wide list of medications, mainly antibiotics. Since its first description by Hoigne and Schoch in 1959, few cases have been reported in medical literature and, although antimicrobials are commonly used, very rarely in dermatology. The authors describe the first case occurred after intralesional administration of meglumine antimoniate and briefly discuss the pathogenetic hypotheses on this atypical adverse drug reaction.