2015
DOI: 10.1016/j.bjid.2015.08.006
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Abstract: A better understanding of the antimicrobial susceptibility, carriage of virulence determinants and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections (SSTIs) may provide further insights related to clinical outcomes with these infections. From January 2012 to September 2013, a total of 128 non-duplicate S. aureus isolates were recovered from patients with SSTIs. All 128 S. aureus SSTI isolates carried at least five virulence genes tested. Virulence genes… Show more

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Cited by 45 publications
(34 citation statements)
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“…A previous study has showed that isolates of nosocomial SCCmec IV and SCCmec III spread from the hospital to the community and vice versa in China (Dan et al, 2010). In this study, 33.3% of MRSA isolates were ST59, consistent with the report that ST59 was the most common clone among MRSA isolates in China (Yu et al, 2015; Yang et al, 2016). Moreover, all of these MRSA isolates harbored the pvl - hlα - fnbA profile, which may cause SSTIs, necrotizing pneumonia, and sepsis.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…A previous study has showed that isolates of nosocomial SCCmec IV and SCCmec III spread from the hospital to the community and vice versa in China (Dan et al, 2010). In this study, 33.3% of MRSA isolates were ST59, consistent with the report that ST59 was the most common clone among MRSA isolates in China (Yu et al, 2015; Yang et al, 2016). Moreover, all of these MRSA isolates harbored the pvl - hlα - fnbA profile, which may cause SSTIs, necrotizing pneumonia, and sepsis.…”
Section: Discussionsupporting
confidence: 91%
“…High antimicrobial resistance could also be observed in MSSA strains belonging to ST7 (average resistance to seven types of antibiotics), with MSSA ST188, ST1, and ST15 (average resistance to five types of antibiotics) displaying a lower prevalence of resistance determinants in this study. A previous study reported the ST7 type of S. aureus isolated from patients with skin and soft tissue infections (SSTIs) in China (Yu et al, 2015); in contrast, ST7 was the predominant molecular type of MRSA strain in a sample from Guangzhou, China (Fan et al, 2016). …”
Section: Discussionmentioning
confidence: 99%
“…In the present study, the majority of the MRSA isolates were resistant to ampicillin (100%), ciprofloxacin (94.5%), gentamicin (98.2%), erythromycin (90.9%), tetracyclin (87.3%), and clindamycin (98.2%), which is in line with the findings reported in Iran (8), Croatia (17), and Turkey (19). The rate of resistance to tested antibiotics, with the exception of amikacin among MRSA isolates, was higher than those among MSSA isolates, which is in accordance with the findings reported by Yu et al (20). In contrast to Ajantha et al (21), the lowest resistance rate (31.1%) was noted against trimethoprim-sulfamethoxazole, as an empirical drug of choice in the treatment of UTI.…”
Section: Discussionsupporting
confidence: 90%
“…This situation could have been caused by the widespread use of antibiotics (particularly β-lactam antibiotics) in China (24) These results suggest that antimicrobial use exerted a strong selective pressure that facilitated the horizontal transfer of antibiotics-resistant genes within the hospital. Compared with the results of a previous study (25), our findings showed lower levels of susceptibility to erythromycin, clindamycin, penicillin, and tetracycline and revealed no significant difference in antimicrobial susceptibility among genetically distinct MRSA isolates (Table 2). Although sulfamethoxazole trimethoprim and clindamycin are the appropriate first-line therapeutic options for the treatment of skin and soft-tissue infections in Europe, wherein CA-MRSA are widespread (26), our results suggest that these antibiotics are not likely to be successful for effective treatment of MRSA infections in Shenzhen, in China.…”
Section: Discussioncontrasting
confidence: 82%