Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit

Resende, Daiane Silva; Peppe, Anna Laura Gil; Reis, Heloísio dos; Abdallah, Vânia Olivetti Steffen; Ribas, Rosineide Marques; Filho, Paulo Pinto Gontijo

doi:10.1016/j.bjid.2014.09.006

Cited by 41 publications

(30 citation statements)

References 24 publications

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“…So, the overall incidence of sepsis in neonates admitted in the NICU was reported as 6.7%. In a similar study by Resende et al in Brazil, out of 551 neonates admitted in the NICU during the study period, 112 neonates developed sepsis (20.3%) [33]. Our results were also similar to the rates reported in developing countries [34,35].…”

Section: Discussion:-supporting

confidence: 91%

Incidence of Late Onset Culture Positive Neonatal Sepsis and Its Antibiotic Sensitivity Pattern.

Tyagi¹,

Suryawanshi²,

Lalwani³

2018

IJAR

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Background and objectives: Sepsis is one of the leading causes of neonatal morbidity and mortality. Because of difference in local epidemiology and variation with time, regular monitoring and updates on pathogen and their antimicrobial sensitivity pattern is important for prevention and treatment. The aim of this study was to study the incidence of late onset Culture Positive Sepsis and Antibiotic Sensitivity Pattern at a Tertiary Care Centre and also evaluate the outcome of culture positive late onset sepsis.

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Section: Discussion:-supporting

confidence: 91%

Incidence of Late Onset Culture Positive Neonatal Sepsis and Its Antibiotic Sensitivity Pattern.

Tyagi¹,

Suryawanshi²,

Lalwani³

2018

IJAR

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“…[1][2][3][4][5][6][7][8] The burden of LOS is significant in developed 2,8,9 and developing nations of the world. [10][11][12][13] The incidence of LOS varies inversely with gestational age and birth weight. 4 The important risk factors for LOS in preterm infants are intravascular catheters, delayed commencement of enteral feeds, prolonged use of parenteral nutrition, prolonged ventilation, and surgery.…”

mentioning

confidence: 99%

Probiotic Supplementation and Late-Onset Sepsis in Preterm Infants: A Meta-analysis

et al. 2016

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CONTEXT: Late-onset sepsis (LOS) is a major cause of mortality and morbidity in preterm infants. Despite various preventive measures, its incidence continues to remain high, hence the urgent need for additional approaches. One such potential strategy is supplementation with probiotics. The updated Cochrane Review (2014) did not find benefits of probiotics in reducing the risk of LOS in preterm infants (19 studies, N = 5338). Currently there are >30 randomized controlled trials (RCTs) of probiotics in preterm infants that have reported on LOS. OBJECTIVES:To conduct a systematic review including all relevant RCTs.DATA SOURCES: PubMed, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, and E-abstracts from the Pediatric Academic Society meetings and other pediatric and neonatal conference proceedings were searched in June and August 2015.STUDY SELECTION: RCTs comparing probiotics versus placebo/no probiotic were included. DATA EXTRACTION:Relevant data were extracted independently by 3 reviewers. RESULTS:Pooled results from 37 RCTs (N = 9416) using fixed effects model meta analysis showed that probiotics significantly decreased the risk of LOS (675/4852 [13.9%] vs 744/4564 [16.3%]; relative risk, 0.86; 95% confidence interval, 0.78-0.94; P = .0007; I 2 = 35%; number needed to treat, 44). The results were significant even after excluding studies with high risk of bias. CONCLUSIONS: Probiotic supplementation reduces the risk of LOS in preterm infants.a Neonatal ICU, King Edward Memorial Hospital for Women, Perth, Western Australia; b Neonatal ICU, Princess Margaret Hospital for Children, Perth, Western Australia; c Centre for Neonatal Research and Education, School of Pediatrics and Child Health, University of Western Australia, Perth, Western Australia; d Neonatal ICU, Nepean Hospital, Kingswood, NSW, Australia; and e Sydney Medical School, Nepean, University of Sydney, Australia Dr Rao conceptualized and designed the study, performed an independent literature search, selected studies for inclusion, extracted and interpreted data, assessed risk of bias of included studies, handled the meta-analysis software, and wrote the fi rst and fi nal drafts of the manuscript; Dr Athalye-Jape performed an independent literature search, selected studies for inclusion, contacted authors for additional information where necessary, extracted and interpreted the data, checked the data entered by S.C.R. on the meta-analysis software, assessed the risk of bias of included studies, and helped with the fi rst and the fi nal draft of the manuscript; Dr Deshpande performed an independent literature search, selected studies for inclusion, verifi ed the extracted data, assessed risk of bias, interpreted data, and oversaw translation of manuscripts in the Chinese language; Dr Simmer supervised the project, interpreted the data, and supervised the fi rst and fi nal versions of the manuscript; Dr Patole supervised the project, acted as referee author in case of d...

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“…The most common empirical choices of antibiotics for the treatment of neonatal sepsis were Aminoglycoside (in EOS 5, 71.42%; in LOS 7, 22.58%) and Penicillin (in EOS 4, 57.14%; in LOS 12, 38.70%) and for both categories. Of the 24 newborns receiving antibiotic empirical therapy, 16 (66.66%) of them had associations of drug classes (14,58.33% received association with 2 classes and 2, 8.33% association with 3 classes). The most common association of drug classes was Penicillin with Aminoglycosides (7, 43.75%).…”

Section: Resultsmentioning

confidence: 99%

Biochemical Changes Occuring in Neonates with Sepsis

Kosovski¹,

Ghiga

Ciurea

et al. 2019

Acta Biologica Marisiensis

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This retrospective study aims to analyze the relationship between biochemical changes occurring in newborns with sepsis proven by positive blood culture (BC) and possible correlations with 1 min Apgar score, 5 min Apgar score, gestational age (GA), and birth weight (BW). We included in the study all infants ≤7 days of life with positive BC that were admitted to the Neonatal Intensive Care Unit (NICU) and Neonatology Department (ND) of the County Emergency Clinical Hospital of Târgu Mureş, a tertiary level hospital, between 2014-2018. The analyzed parameters are: day of life for blood sampling (0-7 days of life), gender, Apgar score (1 and 5 minute), GA, BW, urea, creatinine, total bilirubin, direct bilirubin, aspartate aminotransferase (AST/GOT), alanine aminotransferase (ALT/GPT), c-reactive protein (CPR), bacteria involved, empiric antibiotics administered before blood sampling, temperature of the newborn on the day of BC. We found there is a statistically significant negative correlation between 1 and 5 min Apgar score and creatinine, between GA and urea and also between BW, GA and Direct Bilirubin. We found a statistically significant positive correlation between BW, GA and GPT.

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Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit

Abstract: Through simple infection control measures, LOS can be successfully controlled especially in NICUs of limited resources countries such as ours.

Cited by 41 publications

References 24 publications

Incidence of Late Onset Culture Positive Neonatal Sepsis and Its Antibiotic Sensitivity Pattern.

Incidence of Late Onset Culture Positive Neonatal Sepsis and Its Antibiotic Sensitivity Pattern.

Probiotic Supplementation and Late-Onset Sepsis in Preterm Infants: A Meta-analysis

Biochemical Changes Occuring in Neonates with Sepsis

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