Treatment outcome of human immunodeficiency virus and tuberculosis co-infected patients in public hospitals of eastern and southern zone of Tigray region, Ethiopia

Belayneh, Mehretu; Giday, Kalayta; Lemma, Hailemariam

doi:10.1016/j.bjid.2014.09.002

Cited by 35 publications

(52 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with a similar report from the Tigray region, Ethiopia [36] and might be related with the lesser probability of females engaging in risky behaviours such as alcohol, substance, and tobacco abuse (observation). However, TB/HIV coinfection was significantly associated with the age groups of 25-34 and 35-44 years (aOR: 0.44; 95% CI: 0.25-0.8) and (aOR: 0.39; 95% CI: 0.2-0.7), respectively.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, the proportion of patients with successful treatment outcomes (cured and completed) was found to be 90.9%, which is higher than the WHO target set for the Millennium Development Goal(MDG) of 85% [31][32][33] and comparable to that of the milestone target set globally for 2025 of > 90% [1,34].Comparable findings were reported by other Ethiopian studies [5,26,[35][36][37].…”

Section: Discussionsupporting

confidence: 53%

See 1 more Smart Citation

Treatment outcomes of tuberculosis patients under directly observed treatment short-course at Debre Tabor General Hospital, northwest Ethiopia: nine-years retrospective study

et al. 2018

View full text Add to dashboard Cite

Background: Data regarding tuberculosis (TB) treatment outcomes, proportion of TB/HIV co-infection and associated factors have been released at different TB treatment facilities in Ethiopia and elsewhere in the world as part of the auditing and surveillance service. However, these data are missing for the TB clinic offering directly observed treatment short-course (DOTs) at Debre Tabor General Hospital (DTGH). Methods: The authors analysed the records of 985 TB patients registered at the DTGH from September 2008 to December 2016. Data on patients' sex, age, type of TB, and treatment outcomes were extracted from the TB treatment registration logbook. The treatment outcome of patients was categorized according to the National TB and Leprosy Control Program guidelines: cured, treatment completed, treatment failed, died, and not evaluated (transferred out and unknown cases). Results: Around half of the registered patients were males (516, 52.4%). In terms of TB types, 381 (38.7%), 241 (24.5%), and 363 (36.9%) patients had smear-negative pulmonary TB, smear-positive pulmonary TB, and extra pulmonary TB, respectively. Six hundred and seventy-two patients (90.1%) had successful treatment outcomes (cured and treatment completed), while 74 patients (9.9%) had unsuccessful treatment outcomes (death and treatment failure).TB treatment outcome was not associated with age, sex, type and history of TB, or co-infection with HIV (P > 0.05). The proportion of TB/HIV co-infection was at 24.2%, and these were found to be significantly associated with the age groups of 25-34, 35-44 and ≥65 years:(aOR: 0.44; 95% CI: 0.25-0.8), (aOR: 0.39; 95% CI: 0.20-0.70), (aOR: 4.2; 95% CI: 1.30-12.9), respectively. Conclusions: The proportion of patients with successful treatment outcomes was above the World Health Organization target set for Millennium Development Goal of 85% and in line with that of the global milestone target set at > 90% for 2025. Relatively higher proportions of transfer-out cases were recorded in the present study. Similarly, the proportion of TB/HIV co-infection cases was much higher than the national average of 8%.Thus, the health facility under study should develop strategies to record the final treatment outcome of transfer-out cases. In addition, strategies to reduce the burden of TB/HIV co-infection should be strengthened.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 53%

Treatment outcomes of tuberculosis patients under directly observed treatment short-course at Debre Tabor General Hospital, northwest Ethiopia: nine-years retrospective study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Patients with advanced immunosuppression, WHO stage III and IV during initial diagnosis of HIV, were linked with increased risk of unfavorable treatment outcome, consistent with the literature 14,19,28. Patients with advanced disease might be faced with multiple opportunistic infections and low CD4 count which directly affect TB treatment outcome.…”

Section: Discussionsupporting

confidence: 83%

“…Similarly, the study conducted in Northern Ethiopia showed that a CD4 count <200 cells/µL was associated with unfavorable outcome. Besides, WHO clinical stage IV and age >45 years were predictors of unfavorable outcome 19. The study conducted in Northwest Ethiopia reported that being bedridden and experiencing anti-TB medication side effects were associated with treatment failure 20…”

Section: Introductionmentioning

confidence: 99%

Outcome of tuberculosis treatment and its predictors among HIV infected patients in southwest Ethiopia

Kefale¹,

Anagaw²

2017

IJGM

View full text Add to dashboard Cite

BackgroundCo-infection with HIV challenges treatment of tuberculosis (TB) and worsens the outcome. This study aimed to assess the outcome of TB treatment and its predictors among HIV infected patients at Mizan-Tepi University Teaching Hospital (MTUTH), Ethiopia.MethodsMedical records of 188 TB/HIV co-infected patients who attended the TB clinic of MTUTH from September 2012 to December 2015 were reviewed from March 14 to April 1, 2016. The primary endpoints of the study were treatment outcome of TB and its predictors. Data were analyzed by Statistical Package for Social Sciences version 21. Multivariable binary logistic regression analysis was carried out to identify predictors of treatment outcome. Statistical significance was considered at p-value <0.05.ResultThe treatment outcomes of TB patients included in this study were 18 (9.57%) cured, 20 (10.64%) defaulted, 24 (12.77%) died, 39 (20.74%) completed the treatment, and 87 (46.28%) transferred out. A successful treatment outcome was achieved in 57 (30.32%) patients. Initial World Health Organization (WHO) clinical stage III (COR: 2.60; 95%CI: 1.17–5.76) and stage IV (COR: 4.00; 95%CI: 1.29–12.40) were associated with unfavorable outcome. Both WHO stages (III, IV) at the time of HIV diagnosis were independent predictors of poor treatment outcome (AOR: 3.08; 95%CI: 1.14–8.38; AOR: 5.80; 95%CI: 1.36–24.71 respectively). However, smear positive TB was an independent predictor of a favorable treatment outcome (AOR: 2.50; 95%CI: 1.13–5.51).ConclusionThis study revealed that treatment outcome of TB patients was unsatisfactory, which signals a need for improved care. Advanced WHO clinical stages were predictors of poor outcome, while smear positive TB favors good outcome.

show abstract

“…The mortality rate among HIV-positive tuberculous cases (20.0%) was significantly higher than those testing HIV negative (6.3%) and those not tested (8.9%). This finding is consistent with the reported death rate of 25.7% among HIV and tuberculosis co-infected patients in Ethiopia (16). It should be mentioned that HIV-positive cases in River Nile state receive antiretroviral therapy free of charge.…”

Section: Discussionsupporting

confidence: 91%

Epidemiology of tuberculosis and evaluation of treatment outcomes in the national tuberculosis control programme, River Nile state, Sudan, 2011-2013

Elmadhoun

Noor

Bushara

et al. 2016

East Mediterr Health J

View full text Add to dashboard Cite

Tuberculosis is a major health problem in Sudan, a country that carries 11-15% of the tuberculosis burden in the Eastern Mediterranean Region. This study aimed to describe the epidemiology of tuberculosis in River Nile State and to compare treatment outcomes with WHO recommended indicators. A descriptive study was conducted on data collected from records of 1221 patients registered at tuberculosis management units over the 3 years 2011-2013. The mean age of cases was 37.7 (SD 21.5) years and 65.9% were males; 76.3% were pulmonary tuberculosis and 36.9% were sputum smear-positive cases. Average values for all outcome indicators were suboptimal, notably rates of case notification (30.8 per 100 000), case detection (10.3%), treatment success (79.6%), treatment failure (3.0%), default (8.1%) and death (8.0%). Of the 264 patients tested for HIV, 3.8% were positive. Outcome indicators for the national tuberculosis control programme are lagging behind the required targets. RÉSUMÉ La tuberculose est un problème de santé majeur au Soudan où elle représente 11 à 15 % de la charge de la maladie dans la Région de la Méditerranée orientale. La présente étude avait pour objectif de décrire l'épidémiologie de la tuberculose dans l'État du Nil et de comparer les résultats du traitement à l'aide d'indicateurs recommandés par l'OMS. Une étude descriptive a été menée à partir de données extraites des dossiers de 1221 patients admis dans des unités de prise en charge de la tuberculose sur une période de trois ans (2011)(2012)(2013). L'âge moyen des cas était de 37,7 ans (ET 21,5) et 65,9 % étaient de sexe masculin ; 76,3 % étaient atteints de tuberculose pulmonaire et 36,9 % étaient des cas à frottis positifs. Les valeurs moyennes pour tous les indicateurs de résultats étaient sous-optimales, notamment les taux de notification (30,8 pour 100 000), de dépistage de cas (10,3 %), de guérison (79,6 %), d'échec thérapeutique (3,0 %), d'abandon (8,1 %) et de décès (8,0 %). Sur les 264 patients dépistés pour le VIH, 3,8 % étaient positifs. Les indicateurs de résultats pour le programme national de lutte antituberculeuse accusent un retard par rapport aux objectifs fixés. 2011-

show abstract

Treatment outcome of human immunodeficiency virus and tuberculosis co-infected patients in public hospitals of eastern and southern zone of Tigray region, Ethiopia

Abstract: The rate of treatment success in this study was lower than the rate newly recommended by WHO. Therefore, efforts should be undertaken to improve treatment success rates of both diseases.

Cited by 35 publications

References 6 publications

Treatment outcomes of tuberculosis patients under directly observed treatment short-course at Debre Tabor General Hospital, northwest Ethiopia: nine-years retrospective study

Treatment outcomes of tuberculosis patients under directly observed treatment short-course at Debre Tabor General Hospital, northwest Ethiopia: nine-years retrospective study

Outcome of tuberculosis treatment and its predictors among HIV infected patients in southwest Ethiopia

Epidemiology of tuberculosis and evaluation of treatment outcomes in the national tuberculosis control programme, River Nile state, Sudan, 2011-2013

Contact Info

Product

Resources

About