Does the change on gastrointestinal tract microbiome affects host?

Beirão, Elisa Maria; Padovan, Ana Carolina Barbosa; Furtado, Juvencio; Colombo, Arnaldo Lopes; Medeiros, Eduardo Alexandrino

doi:10.1016/j.bjid.2014.04.002

Cited by 4 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Destruction of the intestinal lining or microbiome during this phase might have induced a more permanent increase in catabolism and metabolism of (essential) amino acids in CD patients. We suggest this issue needs further study in CD patients [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Essential Amino Acids in the Gluten-Free Diet and Serum in Relation to Depression in Patients with Celiac Disease

et al. 2015

View full text Add to dashboard Cite

IntroductionCeliac disease (CD) is associated with an increased risk of major depressive disorder, possibly due to deficiencies in micronutrients in the gluten-free diet. We aimed to investigate whether essential amino acids (i.e., the precursors of serotonin, dopamine and other neurotransmitters) are depleted in the diet and serum of CD patients with major depressive disorder.MethodsIn a cross-sectional study we assessed dietary intake of amino acids and serum levels of amino acids, in 77 CD patients on a gluten-free diet and in 33 healthy controls. Major depressive disorder was assessed with structured interviews (using the Mini International Neuropsychiatric Interview Plus). Dietary intake was assessed using a 203-item food frequency questionnaire.ResultsParticipants had a mean age of 55 years and 74% were women. The intake of vegetable protein was significantly lower in CD patients than in healthy controls (mean difference of 7.8 g/d; 95% CI: 4.7–10.8), as were serum concentrations of tyrosine, phenylalanine and tryptophan (all p < 0.005). However, within the CD patient group, the presence of major depressive disorder (n = 42) was not associated with intake or serum levels of essential amino acids.ConclusionsPatients with CD on a long-term gluten-free diet, with good adherence, consume significantly less vegetable protein than controls, and their serum levels of several essential amino acids were also lower. Despite its potential adverse effect, intake and serum levels of essential amino acids were not related to major depression.

show abstract

Section: Discussionmentioning

confidence: 99%

Essential Amino Acids in the Gluten-Free Diet and Serum in Relation to Depression in Patients with Celiac Disease

et al. 2015

View full text Add to dashboard Cite

show abstract

“…A healthy microbiota is defined as the coexistence of microbial communities, such as pathobionts and commensal bacteria with no harmful consequences. However, a person’s lifestyle and habits may lead to several significant alterations in the native composition and structure of the gastrointestinal microbiota [ 2 ]. In addition, the composition of native gastric microbiota is affected by several factors, such as host health status, H. pylori colonization, chronic infection and subsequent complications, the use and abuse of drugs and toxins, age, surgical interventions, inflammation, alcoholism, smoking, use of nonsteroidal anti-inflammatory drugs (NSAIDs), use of proton pump inhibitors (PPIs), and others [ 18 ], as shown in Figure 2 .…”

Section: Main Findings and Discussionmentioning

confidence: 99%

“…Successful bacterial eradication treatments significantly affect the gastrointestinal microbiota [ 23 ]. Increased improvements in sanitization, hygienical measures, and the extensive use and abuse of antibiotics are considered the most important factors responsible for the reduction in infectious disease transmission, making it important in the induction of significant alterations in the native microbiota composition [ 2 , 53 ]. The consequences of antibacterial therapies are difficult to evaluate since the affected bacteria not only includes pathogens but also beneficial bacteria useful for maintaining human health [ 2 ].…”

Section: Main Findings and Discussionmentioning

confidence: 99%

“…The human microbiome is a collective of pathogenic and commensal microbial communities that colonize the human body [ 1 ]. These communities significantly influence human physiology in processes related to energy homeostasis, neurodevelopment, nutrition, immunologic activity, resistance to pathogens, and gut epithelial health [ 2 , 3 ]. It has been estimated that each person is colonized by a microbial density of approximately 10 14 cells, showing that the number of microbial cells exceeds the total number of cells present in the human body [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Helicobacter pylori and Other Environmental Factors in the Development of Gastric Dysbiosis

et al. 2021

View full text Add to dashboard Cite

Microbiomes are defined as complex microbial communities, which are mainly composed of bacteria, fungi, and viruses residing in diverse regions of the human body. The human stomach consists of a unique and heterogeneous habitat of microbial communities owing to its anatomical and functional characteristics, that allow the optimal growth of characteristic bacteria in this environment. Gastric dysbiosis, which is defined as compositional and functional alterations of the gastric microbiota, can be induced by multiple environmental factors, such as age, diet, multiple antibiotic therapies, proton pump inhibitor abuse, H. pylori status, among others. Although H. pylori colonization has been reported across the world, chronic H. pylori infection may lead to serious consequences; therefore, the infection must be treated. Multiple antibiotic therapy improvements are not always successful because of the lack of adherence to the prescribed antibiotic treatment. However, the abuse of eradication treatments can generate gastric dysbiotic states. Dysbiosis of the gastric microenvironment induces microbial resilience, due to the loss of relevant commensal bacteria and simultaneous colonization by other pathobiont bacteria, which can generate metabolic and physiological changes or even initiate and develop other gastric disorders by non-H. pylori bacteria. This systematic review opens a discussion on the effects of multiple environmental factors on gastric microbial communities.

show abstract

“…72 Microbiome can be considered as another exposure factor on epigenomic level as it is now believed to drastically influence a host organisms' health. [73][74][75][76][77][78][79][80] The understanding of this influence is still in its infancy, but it shows a big potential. Huang et al 81 demonstrated significant association between bacteria abundance and their diversity in airways with bronchial hyperresponsiveness.…”

Section: Epigenomics May Hold Keys To a Missing Genotype-phenotype Linkmentioning

confidence: 99%

What did we learn from multiple omics studies in asthma?

Ivanova

Richards

Vijverberg

et al. 2019

Allergy

View full text Add to dashboard Cite

More than a decade has passed since the finalization of the Human Genome Project.Omics technologies made a huge leap from trendy and very expensive to routinely executed and relatively cheap assays. Simultaneously, we understood that omics is not a panacea for every problem in the area of human health and personalized medicine. Whilst in some areas of research omics showed immediate results, in other fields, including asthma, it only allowed us to identify the incredibly complicated molecular processes. Along with their possibilities, omics technologies also bring many issues connected to sample collection, analyses and interpretation. It is often impossible to separate the intrinsic imperfection of omics from asthma heterogeneity. Still, many insights and directions from applied omics were acquired-presumable phenotypic clusters of patients, plausible biomarkers and potential pathways involved.Omics technologies develop rapidly, bringing improvements also to asthma research. These improvements, together with our growing understanding of asthma subphenotypes and underlying cellular processes, will likely play a role in asthma management strategies.

show abstract

Does the change on gastrointestinal tract microbiome affects host?

Cited by 4 publications

References 40 publications

Essential Amino Acids in the Gluten-Free Diet and Serum in Relation to Depression in Patients with Celiac Disease

Essential Amino Acids in the Gluten-Free Diet and Serum in Relation to Depression in Patients with Celiac Disease

Role of Helicobacter pylori and Other Environmental Factors in the Development of Gastric Dysbiosis

What did we learn from multiple omics studies in asthma?

Contact Info

Product

Resources

About