Presence of highly oncogenic human papillomavirus in the oral mucosa of asymptomatic men

Machado, Ana Paula; Almeida, Flávia Gatto de; Bonin, Camila Mareti; Prata, Thiago Theodoro Martins; Ávilla, Leandro Sobrinho; Padovani, Cacilda Tezelli Junqueira; Ferreira, Alda Maria Teixeira; Fernandes, Carlos Eurico dos Santos; Tozetti, Inês Aparecida

doi:10.1016/j.bjid.2013.07.013

Cited by 14 publications

(13 citation statements)

References 20 publications

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“…Por otro lado, se han desarrollado estudios enfocados en la prevención secundaria y análisis de VPH, principalmente a nivel de citología exfoliativa y prueba molecular para VPH, no solo en CCU, sino en la detección de VPH en lesiones anales y orales (papilomatosis respiratoria recurrente) en diferentes grupos poblacionales (21,38,50,51,(67)(68)(69). A este respecto resaltamos la importancia de las investigaciones sobre la genotipificación de los tipos de VPH que muestran una tendencia concordante con la progresión de las lesiones preneoplásicas de cérvix, situando a los AR-VPH en casi el total de casos de CCU en diferentes grupos poblacionales y asociados a diferentes factores de riesgo (12,(18)(19)(20)(53)(54)(55).…”

Section: Tendencias Y Enfoque Científico Sobre Vph Y Ccuunclassified

Tendencias en la investigación del virus de papiloma humano en Latinoamérica frente a los países de altos ingresos

Moya-Salazar

Rojas‐Zumaran

2017

Rev. Colomb. Obstet. Ginecol.

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Artículo de reflexión RESUMENObjetivo: este documento busca hacer una reflexión sobre las tendencias en la investigación del Virus de Papiloma Humano (VPH) en Latinoaméri-ca en comparación con los países de altos-ingresos. Materiales y métodos: con base en la evaluación de estudios desarrollados en diversos países, discriminados por el grado de desarrollo económico y social, se da respuesta a preguntas relacionadas con el VPH en cuanto a: su frecuencia, las tendencias de investigación, los programas de educación al personal de salud y los pacientes, y las estrategias preventivas. Para esto se realizó una extensa revisión de las investigaciones publicadas y los estudios presentados en el I Encuentro Sudamericano del VPH. Resultados: los esfuerzos para el desarrollo de investigación sobre VPH se reflejan en estudios básicos y aplicados sobre sobre VPH y cancer cervicouterino (CCU). Existen limitaciones en el desarrollo científico regional comparado con los países de ingresos altos que se evidencian en las tasas de prevalencia y vacunación. Se observan transfor- ABSTRACTObjective: This paper is intended to be a reflection on the trends in Human Papilloma Virus (VPH) research in Latin America, compared to high income countries. Materials and methods: Answers are provided regarding HPV in terms of frequency, research trends, education programmes for patients and healthcare staff, and preventive strategies. An extensive review was conducted of the published research and of the studies presented during the I South American Meeting on HPV.Results: Research work in HPV is focused on basic and applied studies on HVP and cervical cancer (CC). There are limitations to scientific development in our region compared to high income countries, and this is reflected in disease prevalence and vaccination rates. Prevention programs at each level

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Section: Tendencias Y Enfoque Científico Sobre Vph Y Ccuunclassified

Tendencias en la investigación del virus de papiloma humano en Latinoamérica frente a los países de altos ingresos

Moya-Salazar

Rojas‐Zumaran

2017

Rev. Colomb. Obstet. Ginecol.

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“…Machado et al (2014) suggested that the practice of oral sex and a high number of partners may increase the risk of HPV infection [17].…”

Section: Epidemiology Of Hpv Infectionmentioning

confidence: 99%

Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets

Simões

Barth

2015

Int Jour of Biomed Res

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Epitheliotropic and mucosotropic Papillomaviruses (PVs) constitute the Papillomaviridae family. There are 26 genera comprising levels of inter species genetic similarities by nucleotide sequence analysis of the L1 viral region, the generally most conserved region among papillomaviruses. There is an increasing consensus that the ideal vector for gene therapy should be completely based on chromosomal elements and behave as an independent functional unit after integration. The present paper is a short review about epidemiology of HPV infection, vaccines anti-HPV and tumors associated with HPV and gene therapy including biological vectors, stem cells, viral and non-viral vectors and chromosome-based vectors. Furthermore, new therapeutic targets and vectors applied in gene therapy of other viruses are some of the examples that have been successfully modified by recombinant DNA techniques. New biotechnologies in molecular biology have been applied in papillomavirus research and are still being investigated for the application in the gene therapy. RNA-sequencing (RNA-seq) for analysis of the transcriptome, multiply-primed rolling circle amplification (RCA) used to identify novel human papillomaviruses (HPV) and new DNA sequencing method based on real-time phyrophosphate are examples as new techniques.

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“…Other types (16,18,31,33,35,39,45,51,52,56,58,59 and 66) of high oncogenic risk are associated with malignant lesions of the oral cavity, mainly squamous cells. 2,3 In Brazil, 500,000 to 1 million cases of HPV infections are estimated annually. 1 Detection rates for HPV in healthy oral mucosa vary significantly around the globe, suggesting that this site may work as a reservoir for Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”

Section: Introductionmentioning

confidence: 99%

“…the virus. 3,4 A population study conducted in the US between 2009 and 2010 with asymptomatic patients reported 6.9% prevalence of oral HPV, 3.7% of which was genotyped as high-risk HPV (HR-HPV) and the other 3.2% as low risk HPV (LR-HPV). 5 In São Paulo state, Brazil, Tristão et al 1 described a prevalence of 23.2% HPV in healthy oral mucosa and associated the presence of the virus with regular oral sex.…”

Section: Introductionmentioning

confidence: 99%

Elevated prevalence of high-risk HPV in healthy oral mucosa of users and nonusers of drugs in Northeastern Brazil

et al. 2019

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Variable rates of HPV infection have been reported in healthy oral mucosa worldwide. The main objective of this study was to detect and genotype HPV infection in users and nonusers of drugs with clinically healthy mucosa from the Northeast Brazil. Samples from 105 patients were amplified using the primers MY09/MY11 and GP5+/GP6+, and genotyping was performed by multiplex-PCR for HPV-6/11, 16 and 18. A total of 81.9% samples were positive. Among drug users, 84.5% presented the virus and 20.4% showed multiple infections. Among non-drug users, 78.7% were positive and 13.5% had multiple infections. Limited information is available on oral HPV in Brazilian population, especially for drug users, and our results showed higher HPV infection rates in both users and nonusers of drugs. More studies and researches focused on drug users including factors like sexual behavior, nutrition and cultural habits are necessary to enhance the comprehension of this relationship, and develop preventive strategies.

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Presence of highly oncogenic human papillomavirus in the oral mucosa of asymptomatic men

Cited by 14 publications

References 20 publications

Tendencias en la investigación del virus de papiloma humano en Latinoamérica frente a los países de altos ingresos

Tendencias en la investigación del virus de papiloma humano en Latinoamérica frente a los países de altos ingresos

Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets

Elevated prevalence of high-risk HPV in healthy oral mucosa of users and nonusers of drugs in Northeastern Brazil

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