Coronaviruses in children with febrile neutropenia

Alvares, Paula Andrade; Berezin, Eitan N.; Botelho, Andrea Cristina Alpoim; Tiemi, Denise; Spinardi, Júlia; Maruyama, Claudia; Bruniera, Paula; Passos, Saulo Duarte; Mimica, Marcelo Jenne

doi:10.1016/j.bjid.2013.07.009

The Brazilian Journal of Infectious Diseases

2014

DOI: 10.1016/j.bjid.2013.07.009

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Coronaviruses in children with febrile neutropenia

Paula Andrade Alvares¹,

Eitan N. Berezin²,

Andrea Cristina Alpoim Botelho³

et al.

Abstract: publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. b r a z j i n f e c t d i s . 2 0 1 4;1 8(1):98-99

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Effects of respiratory viruses on febrile neutropenia attacks in children

Aldemir-Kocabaş¹,

Karbuz²,

Pekpak³

et al. 2017

Turk J Pediatr

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Respiratory tract viruses have an important effect on morbidity and mortality in patients with febrile neutropenia (FN). The aim of this study was to determine frequency and clinical influence of viral respiratory viruses as potential etiologic agents in episodes of FN in children. A total of 100 children (62 boys, 38 girls) with 166 FN episodes were included in this prospective study. Nasopharyngeal aspirate samples were analyzed for respiratory viral agents using multiplex real-time polymerase chain reaction. The origin of the fever could be defined in 111 (67%) of the episodes. We detected viral agents in 86 (51.8%), bacterial agents in 19 (11.4%), and fungal agents in 5 (3%) of the episodes. The most common detected viruses were rhinovirus (n= 27), respiratory syncytial virus (n=17), and coronavirus (n=16). Parainfluenza virus, influenza A and B, adenovirus, human metapneumovirus, enterovirus, bocavirus and parechovirus were the remaining detected agents. More than one virus positivity occurred in 13 FN episodes. Forty-three patients had multiple FN episodes. Only four patients had the same viral agent in consecutive attacks. Respiratory symptoms (cough, nasal discharge and congestion, sneezing, wheezing), physical examination signs (rales and rhonchi) and radiological findings were significantly more common in viral agent positive patients (p < 0.05). This study showed that respiratory viruses make a substantial contribution on the etiology of FN episodes in children. Identifying viral agents may help to constitute individualized infection-management algorithms in these patients.

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Effects of respiratory viruses on febrile neutropenia attacks in children

Aldemir-Kocabaş¹,

Karbuz²,

Pekpak³

et al. 2017

Turk J Pediatr

View full text Add to dashboard Cite

show abstract

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Coronaviruses in children with febrile neutropenia

Cited by 1 publication

References 5 publications

Effects of respiratory viruses on febrile neutropenia attacks in children

Effects of respiratory viruses on febrile neutropenia attacks in children

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