Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia

Jiang, Wujun; Ji, Wei; Wang, Yuqing

doi:10.1016/j.bjid.2013.06.004

Cited by 16 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only the repMP1-based approach was able to detect 0.2 CFU/5 l in all parallel runs. Results of studies indicated that the bacterial load might influence the severity of disease after infection with M. pneumoniae (16,17). The data of the present and other comparison reports confirmed that the PCR approach used will influence the positivity rate of tested samples and the measured load of M. pneumoniae in the specimens.…”

supporting

confidence: 81%

See 1 more Smart Citation

Evaluation of Five Real-Time PCR Assays for Detection of Mycoplasma pneumoniae

Dumke

Jacobs

2014

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

supporting

confidence: 81%

“…Despite differences among the methods regarding PCR efficiency, C T values, and analytical and clinical sensitivity, all systems detect at least 20 CFU/5 l of sample. With regard to the quantitative results of other studies based on real-time PCR (16,17,20,21), this can be considered an acceptable level of test sensitivity for most clinical questions. …”

mentioning

confidence: 99%

Evaluation of Five Real-Time PCR Assays for Detection of Mycoplasma pneumoniae

Dumke

Jacobs

2014

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Seasonal peaks of MP infection in LRTI has been reported in our previous studies. Outbreaks began in summer months and peaked during August and September in Suzhou [ 9 , 18 ]. The seasonal distribution in our non-KD group is in line with our previous studies.…”

Section: Discussionmentioning

confidence: 99%

Kawasaki disease associated with Mycoplasma pneumoniae

et al. 2016

View full text Add to dashboard Cite

BackgroundKawasaki disease (KD) is an illness of unknown etiology that mostly occurs in children under 5 years of age and is the leading cause of acquired heart disease all over the world. Mycoplasma pneumoniae (MP) was one of the likely causative agents of KD. However, the etiologic effect of MP in KD has not been fully recognized.MethodsWe prospectively analyzed the clinical records of 450 patients with KD hospitalized in Children’s Hospital of Soochow University from 2012 to 2014. Using medical records, we retrospectively identified patients with low respiratory tract infection (non-KD group).ResultsOf the 450 KD patients, MP was positive in 62 (13.8 %). The median age of the MP + KD+ group was significantly older than the MP-KD+ group (25 vs 14.5 months, P < 0.01). MP + KD+ group had higher levels of ESR, N% and CRP than the MP-KD+ group. MP + KD+ group were more frequent in respiratory disorders than MP-KD+ group with a P < 0.05. No statistical difference of non-responders or coronary artery lesion was found between the groups.ConclusionsMP infections are found in an important proportion of the KD patients (13.8 % in our series). MP infection tended to occur in older populations and with a higher rate of respiratory tract involvement in patients with KD. No statistical difference of non-responders or coronary artery lesion was found between the MP+ and MP- KD patients.

show abstract

“…It is believed that high fever is more likely to occur when the MP load is greater than 10 7 copies/µl. However, the relationship between low MP load and pathogenesis is not clear 17 .…”

Section: Discussionmentioning

confidence: 99%

Evaluating Laboratory Diagnoses of Children’s Mycoplasma Pneumoniae Infection Reveal Effective Clinical Approaches

Wang

Han²,

Ran

et al. 2019

Preprint

View full text Add to dashboard Cite

This study aims to evaluate laboratory methods for the diagnosis of Mycoplasma pneumoniae . Ninety-three children infected with Mycoplasma pneumoniae were tested, and large sample size makes the results representative. The pharyngeal swabs and serum samples were mostly collected from the first week of the disease, or from the second to third week of the disease in recovery children. The pharyngeal swabs from healthy children were cultured and two of them were positive for the bacterium. The accuracy of laboratory diagnostic methods for Mycoplasma pneumoniae were evaluated against serum test with 4-fold increase or decrease in the titers of antibody in two serum samples. The specificity of culture method was high, which suggested that the method was suitable for clinical research. In acute phase, the sensitivities of single serological test or simultaneous amplification and testing of Mycoplasma pneumoniae (SAT) were 71.7% and 85%, respectively.

show abstract

Clinical significance of different bacterial load of Mycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia

Abstract: M. pneumoniae at a high bacterial load could be an etiologic agent of respiratory tract disease, whereas the etiologic role of MP at a low bacterial load remains to be determined.

Cited by 16 publications

References 16 publications

Evaluation of Five Real-Time PCR Assays for Detection of Mycoplasma pneumoniae

Evaluation of Five Real-Time PCR Assays for Detection of Mycoplasma pneumoniae

Kawasaki disease associated with Mycoplasma pneumoniae

Evaluating Laboratory Diagnoses of Children’s Mycoplasma Pneumoniae Infection Reveal Effective Clinical Approaches

Contact Info

Product

Resources

About