Categorization of dengue fever according to phase of illness—a suggestion for clinical studies using single diagnostic sample

Bhaskar, Emmanuel; Praveena, R.; Gopalan, Sowmya; Moorthy, Swathy

doi:10.1016/j.bjid.2013.05.003

Cited by 2 publications

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References 4 publications

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“…For a priori adjustments, the multivariable models were adjusted for the variables for age (a known confounder for dengue and its clinical presentation for primary infection vs. subsequent infections [ 27 , 28 ], further collapsed to 4-level categorical variable); gender (we had a priori reasons for believing that gender might be related to likelihood of exposure to the Aedes vectors and it might mediate some of the clinical presentations [ 29 ]) although in our data its inclusion or exclusion did not make difference to the odds ratios in the final model); timing of fever occurrence (whether the episode occurred during a known dengue season, often coinciding with a rainy period, may affect dengue diagnosis and physicians’ focus when making examinations for symptoms, etc. [ 30 , 31 ]); and, fever duration prior to visit (possibly affecting how symptoms are clinically presented at enrollment by the duration of illness and level of viremia for dengue confirmation [ 32 ]). Then, a multivariable backward stepwise logistic regression model was applied with a significance level 0.2 for entry and 0.1 for staying in the adjusted model.…”

Section: Methodsmentioning

confidence: 99%

Clinical and epidemiologic characteristics associated with dengue fever in 2011–2016 in Bang Phae district, Ratchaburi province, Thailand

et al. 2021

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Background Dengue is a major public health problem in Thailand, but data are often focused on certain dengue-endemic areas. Methods: To better understand dengue epidemiology and clinical characteristics in Thailand, a fever surveillance study was conducted among patients aged 1–55 years, who presented with non-localized febrile illness at Bang Phae Community Hospital in Ratchaburi province, Thailand from October 2011 to September 2016. Results Among 951 febrile episodes, 130 were dengue-confirmed. Individuals aged 10–14 years were mostly affected, followed by those 15–19 years-of-age, with about 15% of dengue-confirmed cases from adults 25 years and older. There were annual peaks of dengue occurrence between June-November. Most prevalent serotype in circulation was DENV-2 in 2012, DENV-3 in 2014, and DENV-4 & -3 in 2015. Among dengue cases, 65% were accurately detected using the dengue NS1 RDT. Detection rate was similar between secondary and primary dengue cases where 66% of secondary vs. 60% of primary dengue cases had positive results on the NS1 RDT. Among dengue cases, 66% were clinically diagnosed with suspected dengue or DHF, prior to lab confirmation. Dengue was positively associated with rash, headache, hematemesis and alterations to consciousness, when compared to non-dengue. Dengue patients were 10.6 times more likely to be hospitalized, compared to non-dengue cases. Among dengue cases, 95 were secondary and 35 were primary infections. There were 8 suspected DHF cases and all were identified to be secondary dengue. Secondary dengue cases were 3.5 times more likely to be hospitalized compared to primary dengue cases. Although the majority of our dengue-positive patients were secondary dengue cases, with few patients showing manifestations of DHF, our dengue cases were mostly mild disease. Even among children < 10 years-of-age, 61% had secondary infection and the rate of secondary infection increased with age. Conclusion While the majority of dengue-confirmed cases were children, almost three-quarters of dengue-confirmed cases in this study were secondary dengue. Our study results consistent with previous data from the country confirm the hyperendemic transmission of DENV in Thailand, even in the non-epidemic years. With various interventions becoming available for dengue prevention and control, including dengue vaccines, decision-making on future implementation strategies should be based on such burden of disease data.

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Section: Methodsmentioning

confidence: 99%

Clinical and epidemiologic characteristics associated with dengue fever in 2011–2016 in Bang Phae district, Ratchaburi province, Thailand

et al. 2021

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“…Dengue fever is characterized by an initial viremic phase which corresponds to the first 3 days of illness followed by immune phase (also called critical phase) spanning from 3rd to 6th day of illness, the phase beyond 6th of illness is called recovery phase [5].…”

Section: Introductionmentioning

confidence: 99%

Study of Prevalence Presentation and Outcome of Plasma Leakagein Dengue Fever Patients Attending Private Medical Clinic inAden - Yemen

Gabali

2021

The Medical Journal of Cairo University

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Background: Dengue virus infections are a significant threat to human populations particularly in the tropical and subtropical regions. Aedes aegypti mosquito from humans to humans mainly transmits this. The main pathological mechanisms associated include thrombocytopenia and plasma leakage. Aim of Study: This study aimed to describe the prevalence presentation and outcome of plasma leakage in dengue fever patients attended a private clinic in Aden-Yemen. Patients and Methods: A retrospective study included 50 patients with dengue fever presented with fever and confirmed with positive dengue NS 1 antigen in the blood in the period from May to October 2020; all patients had done abdomen sonogram for plasma leakage features gall bladder wallo edema, ascites and pleural effusion. Results: 50 patients were recruited in this study, male constitute (60%) female (40%), (58%) of patients came from urban areas, while (42%) came from rural areas, (40%) of patients had plasma leakage manifestation seen by sonogram, (75%) of those patients with plasma leakage were female, (25%) were male, Thick gall bladder is the most common finding in sonogram (70%) reflecting plasma leakage, Overall mortality was (2%) in the enrolled patients in this study. Conclusion: Prevalence presentation and outcome of plasma leakage among dengue fever Yemeni patients do not remarkably differ from studies carried out worldwide.

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Categorization of dengue fever according to phase of illness—a suggestion for clinical studies using single diagnostic sample

Cited by 2 publications

References 4 publications

Clinical and epidemiologic characteristics associated with dengue fever in 2011–2016 in Bang Phae district, Ratchaburi province, Thailand

Clinical and epidemiologic characteristics associated with dengue fever in 2011–2016 in Bang Phae district, Ratchaburi province, Thailand

Study of Prevalence Presentation and Outcome of Plasma Leakagein Dengue Fever Patients Attending Private Medical Clinic inAden - Yemen

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