Psychopathology and psychosocial adjustment in patients with HIV-associated lipodystrophy

Barata, Anna; Malouf, Jorge; Gutiérrez, Mar; Mateo, Gràcia; Sambeat, María A.; Gich, Ignasi; Cadafalch, Josep Puig i; Wulff, Juan; Domingo, Peré

doi:10.1016/j.bjid.2012.11.011

Cited by 4 publications

(4 citation statements)

References 22 publications

(32 reference statements)

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“…In addition, mean of anxiety was 47.14 point in the low-risk group and mean of anxiety was 50.90 point in the moderate/high-risk group. Compared to the anxiety levels of HIV-positive individuals in previous studies using the same STAI instrument, the level found in this study is higher [31]. In a qualitative study in Korea, the lives of people living with HIV/AIDS were found to be characterized by the theme of "living with the yoke of HIV" [12].…”

Section: E P U B a H E A D O F P R I N Tcontrasting

confidence: 85%

Associations of depression and anxiety with cardiovascular risk among people living with HIV/AIDS in Korea

et al. 2020

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OBJECTIVES As HIV/AIDS is becoming a chronic disease, the risk of developing cardiovascular disease (CVD) among people living with HIV/AIDS is rising. Anxiety and depression, which are common among people living with HIV/AIDS, have been linked with CVD. This study investigated the risk of CVD in people living with HIV/AIDS and explored the effects of depression and anxiety on CVD risk. METHODS Data were collected for 457 people enrolled in the Korea Cohort HIV/AIDS study after 2010. Framingham risk scores were calculated to quantify the 10-year risk of developing CVD. Depression and anxiety variables were re-coded as a single combined variable. Multivariable logistic regression analysis was performed, adjusting for age, body mass index, low-density lipoprotein (LDL) cholesterol, triglycerides (TG), duration of human immunodeficiency virus (HIV) positivity after entry into the cohort, and depression/anxiety. RESULTS Participants with both depression and anxiety were 2.28 times more likely than those with neither depression nor anxiety to have moderate/high-risk CVD risk. The 10-year risk of developing CVD was affected by LDL cholesterol, TG, age, and duration of HIV infection. LDL cholesterol and TG levels change according to the duration of HIV infection, and metabolic disorders affect the risk of CVD. Thus, a longer duration of HIV infection is associated with a higher risk of developing CVD. CONCLUSIONS Screenings for depression and anxiety need to be provided regularly to assess the severity of those symptoms. To help decrease their risk of developing CVD, people living with HIV/AIDS should be offered behavioral modification interventions aimed at developing healthy lifestyle habits.

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Section: E P U B a H E A D O F P R I N Tcontrasting

confidence: 85%

Associations of depression and anxiety with cardiovascular risk among people living with HIV/AIDS in Korea

et al. 2020

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“…A lipodistrofia, caracterizada pela redistribuição da gordura corporal, é uma das alterações mais evidentes. A mais importante apresentação clínica desta síndrome é caracterizada pela perda de gordura (lipoatrofia), principalmente, na face, nos membros e nas nádegas e, em alguns casos, com acúmulo de gordura no abdômen, seios e região cervical (BARATA et al, 2013).…”

Section: Alterações Associadas Ao Uso Das Terapias Antirretroviraisunclassified

“…Já para Barata (2013), as manifestações físicas dos efeitos secundários ao tratamento antirretroviral, por exemplo, a lipodistrofia, afeta a autoestima que aumenta os sentimentos de estigma, o que pode causar mudanças no comportamento psicológico levando a uma participação limitada na vida social e profissional. Consequentemente, eventos de estresse, trauma e depressão produzem um efeito negativo em importantes componentes do sistema imune, como nos Linfócitos T CD4, que por sua vez, pode prejudicar a evolução do tratamento.…”

Section: Alterações Associadas Ao Uso Das Terapias Antirretroviraisunclassified

Associação entre o uso de antirretrovirais no tratamento para HIV e alterações físicas e metabólicas

Rodovalho¹,

Tristão²,

Galvão³

et al. 2017

Anais Do Simpósio De Metodologias Ativas - Inovações Para O Ensino E a Aprendizagem Na Educação Básica E Superior &Amp; III Sim

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“…: cosmetic result, antiretroviral tolerance, global wellbeing, social isolation) and may influence the results. Barata et al assessed a psychological questionnaire in outpatients with and without LD and found no difference in mental health disorders between the two groups [ 25 ]. Rajagopalan et al found similar results regarding quality of life; however, a subgroup analysis showed that patients with LD, particularly homosexual men and patients undergoing psychiatric treatment, suffered from a low QoL [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders

et al. 2015

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BackgroundLipodystrophy (LD) is a frequent adverse event of combination antiretroviral therapy (ART) and occurs mainly in patients exposed to first-generation antiretroviral drugs. The aim of this study was to explore and measure the interaction between LD, mental health, and quality of life of human immunodeficiency virus (HIV) positive individuals seen in a metabolic clinic.MethodsWe conducted a single-site cross-sectional study including all HIV-infected patients attending the LIPO group and metabolism day clinic at the University Hospitals of Geneva, Switzerland between January 31, 2008 and November 28, 2013. Data on LD were prospectively collected using the HIV Outpatient Study (HOPS) score, the Lipodystrophy Case Definition (LDCD), ART regimens, anthropometric measures, imaging, and standardized questionnaires. Quality of life was evaluated using a visual analog scale of 0–100. Depression and anxiety were assessed using the Beck Depression Inventory and the State Trait Anxiety Inventory scales, respectively.ResultsOne hundred ninety-four patients (54.6% male; 45.4% female; median age, 50 years) on successful ART (median CD4 cell count, 569.0 cells/mm3; median viral load, 20 copies/mL) were evaluated. Among these, 62.7, 63.5 and 35.5% of patients reported at least one body site affected by fat hypertrophy, atrophy or both, respectively. Using the LDCD score conservative definition, including imaging and biological values, 57.8% were diagnosed with LD. Of these, 39.7% suffered from severe/very severe LD. Depression was reported by 35.6% of individuals; 51.9% had anxiety symptoms and 49.5% reported poor quality of life (defined as being inferior to 50% on a scale from 0 to 100%). LD (odds ratio (OR = 5.22, 95% confidence interval (CI) 1.07–25.37, p-value: 0.040), depression (OR = 4.67, 95% CI 1.08–20.31, p-value 0.040), and anxiety (OR = 7.83, 95% CI 1.91–32.03, p-value 0.004) all affected significantly the quality of life.ConclusionsLD, depression and anxiety were frequent features among HIV-infected individuals seen in the metabolic clinic and significantly impacted on their quality of life.Electronic supplementary materialThe online version of this article (doi:10.1186/s12981-015-0061-z) contains supplementary material, which is available to authorized users.

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Psychopathology and psychosocial adjustment in patients with HIV-associated lipodystrophy

Cited by 4 publications

References 22 publications

Associations of depression and anxiety with cardiovascular risk among people living with HIV/AIDS in Korea

Associations of depression and anxiety with cardiovascular risk among people living with HIV/AIDS in Korea

Associação entre o uso de antirretrovirais no tratamento para HIV e alterações físicas e metabólicas

Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders

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