The clinical features and outcomes of acute liver failure associated with dengue infection in adults: a case series

Tan, Soek‐Siam; Bujang, Mohamad Adam

doi:10.1016/j.bjid.2012.09.007

Cited by 52 publications

(41 citation statements)

References 29 publications

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“…En este estudio se encontró una mayor proporción de pacientes con alteración de las transaminasas, en comparación con lo reportado por Kuo, et al, pues la proporción de quienes tenían niveles diez veces por encima del límite superior de AST y ALT fue: 25 % Vs. 11,1 % y 12,5 % Vs. 7,4 %, respectivamente; sin embargo, los niveles de transaminasas de los hospitalizados en la unidad de cuidados intensivos fueron más bajos que los reportados en otras series (26,28).…”

Section: Discussionunclassified

Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Rosso¹,

Vanegas

Rodríguez

et al. 2016

biomedica

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Contribución de los autores:Róbinson Pacheco y Fernando Rosso: desarrollo de la idea, diseño del estudio y revisión crítica del contenido Sarita Rodríguez: creación de la base de datos, análisis de la información, revisión crítica del contenido Sara Vanegas: revisión de la literatura, diseño del estudio, recolección de datos y análisis de la información Todos los autores participaron en la redacción del manuscrito.Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia Introducción. Hay pocas series de casos publicadas sobre la prevalencia y el curso clínico del dengue en adultos mayores con síndrome febril, habitantes en zonas endémicas para la infección. Se cree que tales casos presentan una baja prevalencia pero revisten mayor gravedad, y más complicaciones y mortalidad. Objetivos. Describir la prevalencia y el curso clínico del dengue en adultos mayores atendidos por síndrome febril agudo en un hospital de alta complejidad de una zona endémica de la enfermedad. Introduction: Little is known about the prevalence and clinical course of dengue infection in elderly patients living in endemic areas; it is presumed that there is a lower prevalence but higher severity, complications and mortality. Objective: To describe the prevalence and clinical course of dengue infection in elderly patients who were admitted to a referral care center for infectious diseases in an endemic region. Materials and methods:We conducted an observational and descriptive study between 2011 and 2014, using a cohort of elderly patients with serological diagnosis of dengue.Results: A total of 235 febrile elderly patients were assessed, of which 43 patients (18.3%) were found to have dengue. The median age was 71 years; 48.7% were female, and 89% of patients had at least one comorbid condition. According to the serological tests, 51.4% of cases were positive for NS1 Ag, 27% for IgM and 54.1% for IgG, while 64.8% were secondary infections. Dengue was diagnosed in 13 patients (35%), dengue with warning signs in 16 cases (43%), and severe dengue in 8 cases (22%). Nearly 56.7% of patients were admitted to hospital and 21.6%, to the intensive care unit. None died. 180Biomédica 2016;36(Supl.2):179-86 Rosso F, Pacheco R, Rodríguez S, Vanegas S Conclusion: We found dengue infection to be more frequent than expected in this sample of elderly patients, due to acute febrile syndrome. Elderly patients also required higher rate of hospitalization and had more complications, however there were no deaths due to good management.

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Section: Discussionunclassified

Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Rosso¹,

Vanegas

Rodríguez

et al. 2016

biomedica

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“…While severe hepatitis where transaminase levels rise more than 10 times the upper limit value of normal is only found at 3-11%. 10 Characteristic features of liver cells damage in dengue is ALT levels higher than AST. This condition is different from liver damage due to hepatitis virus.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the usage of drugs such as acetaminophen or paracetamol are often used to overcome the fever or stiffness in dengue, also contributes to liver damage. 10,12 The diagnosis of acute fulminant hepatitis in this patient is established on the third day of treatment based on rapid liver dysfunction (elevated fastly of liver transaminase levels) with encephalopathy, in patients without prior liver disease history (no evidence of viral hepatitis involvement).…”

Section: Discussionmentioning

confidence: 99%

Dengue Hemorrhagic Fever with Acute Fulminant Hepatitis: A Case Report

Firmansyah¹

2020

InaJGHE

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Dengue virus is estimated to cause over 100 million infections throughout the world annually. Although dengue infections can have a wide range of clinical pictures, atypical manifestations have been described recent years. The liver is a susceptible organ affected in dengue infection. Mild liver dysfunction is common in cases of dengue infection but severe liver function impairment and even encephalopathy are rare. The following is a case report of dengue hemorrhagic fever (DHF) with acute fulminant hepatitis. A 43-year-old woman has fulminant hepatitis on day 3 of treatment. Her AST level increased dramatically from 363 U/L to 3,246 U/L. The causes of other hepatitis infection has been excluded. Her dengue IgM-antibody level was reactive. Level of dengue IgM antibody reactive. Clinical improvement experienced by patient after supportive therapy and administration glisirizin or Stronger Neo-Minophagen-C (SNMC). Keywords: dengue haemorrhagic fever, fulminant, glycyrrhizin, hepatitis, infectione, stronger neominophagen-C, SNMC ABSTRAK Virus dengue diperkirakan menyebabkan lebih dari 100 juta kasus infeksi dengue di seluruh dunia. Meskipun gambaran klinis bervariasi namun dewasa ini didapatkan manifestasi klinis yang tidak khas. Hati adalah organ yang rentan terkena dalam infeksi dengue. Gangguan fungsi hati ringan kerap dijumpai pada kasus infeksi dengue namun gangguan fungsi hati berat bahkan disertai ensefalopati jarang dijumpai. Berikut adalah laporan kasus demam berdarah dengue dengan hepatitis akut fulminan. Perempuan 43 tahun mengalami hepatitis fulminan pada hari ke-3 perawatan. Kadar SGPT meningkat drastis dari 363 U/L menjadi 3.246 U/L. Penyebab infeksi hepatitis lainnya telah disingkirkan. Kadar antibodi IgM dengue reaktif. Perbaikan klinis dialami pasien pasca terapi suportif dan pemberian glisirizin atau Stronger Neo-Minophagen-C (SNMC).Kata kunci: dengue berdarah dengue, fulminan, glisirizin, hepatitis, infeksi, stronger neo-minophagen-C, Stronger Neo-Minophagen-C (SNMC)

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“…64 Hepatitis is common and can be found in 60-90% of dengue-infected patients. 65 Most of cases with hepatitis have mild disease with less than 11% cases developing a rise in transaminases above ten times the upper limits of normal. 66 Usually the SGOT levels are more than SGPT levels probably due to skeletal muscle injury.…”

Section: Dengue Fevermentioning

confidence: 99%

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

Anand

Garg

2015

Journal of Clinical and Experimental Hepatology

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The clinical features and outcomes of acute liver failure associated with dengue infection in adults: a case series

Abstract: Dengue associated ALF manifest about one week after the onset of fever with severe hepatitis and encephalopathy. In our experience, the outcome with standard medical therapy alone is excellent.

Cited by 52 publications

References 29 publications

Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Dengue Hemorrhagic Fever with Acute Fulminant Hepatitis: A Case Report

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

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