Dengue virus is estimated to cause over 100 million infections throughout the world annually. Although dengue infections can have a wide range of clinical pictures, atypical manifestations have been described recent years. The liver is a susceptible organ affected in dengue infection. Mild liver dysfunction is common in cases of dengue infection but severe liver function impairment and even encephalopathy are rare. The following is a case report of dengue hemorrhagic fever (DHF) with acute fulminant hepatitis. A 43-year-old woman has fulminant hepatitis on day 3 of treatment. Her AST level increased dramatically from 363 U/L to 3,246 U/L. The causes of other hepatitis infection has been excluded. Her dengue IgM-antibody level was reactive. Level of dengue IgM antibody reactive. Clinical improvement experienced by patient after supportive therapy and administration glisirizin or Stronger Neo-Minophagen-C (SNMC). Keywords: dengue haemorrhagic fever, fulminant, glycyrrhizin, hepatitis, infectione, stronger neominophagen-C, SNMC ABSTRAK Virus dengue diperkirakan menyebabkan lebih dari 100 juta kasus infeksi dengue di seluruh dunia. Meskipun gambaran klinis bervariasi namun dewasa ini didapatkan manifestasi klinis yang tidak khas. Hati adalah organ yang rentan terkena dalam infeksi dengue. Gangguan fungsi hati ringan kerap dijumpai pada kasus infeksi dengue namun gangguan fungsi hati berat bahkan disertai ensefalopati jarang dijumpai. Berikut adalah laporan kasus demam berdarah dengue dengan hepatitis akut fulminan. Perempuan 43 tahun mengalami hepatitis fulminan pada hari ke-3 perawatan. Kadar SGPT meningkat drastis dari 363 U/L menjadi 3.246 U/L. Penyebab infeksi hepatitis lainnya telah disingkirkan. Kadar antibodi IgM dengue reaktif. Perbaikan klinis dialami pasien pasca terapi suportif dan pemberian glisirizin atau Stronger Neo-Minophagen-C (SNMC).Kata kunci: dengue berdarah dengue, fulminan, glisirizin, hepatitis, infeksi, stronger neo-minophagen-C, Stronger Neo-Minophagen-C (SNMC)