Microbial contamination of single- and multiple-dose vials after opening in a pulmonary teaching hospital

Baniasadi, Shadi; Dorudinia, Atosa; Mobarhan, Mandana; Gamishan, Masoumeh Karimi; Fahimi, Fanak

doi:10.1016/j.bjid.2012.09.005

Cited by 16 publications

(19 citation statements)

References 21 publications

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“…In this study, the incidence of drug contamination was 2.8%, which was within the range of other reported studies (5,6,9,(12)(13)(14). However, Driver et al (2) and Wagner et al (4) studied the sterility of the anaesthetic and resuscitative drug syringes used in obstetric operating rooms and found no organisms in any syringe.…”

Section: Discussionsupporting

confidence: 83%

Bacterial Contamination of Anaesthetic and Vasopressor Drugs in the Operating Theatres

Rueangchira-urai¹,

Rujirojindakul²,

Geater³

et al. 2017

Turk J Anaesth Reanim

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Objective: The aim of this study was to determine the incidence of bacterial and fungal contamination in anaesthetic and vasopressor drugs before and after use in operating theatres. Methods:A cross-sectional study was conducted in the operating theatres of a university hospital. We collected 945 samples of three different drugs, namely, propofol, vecuronium and ephedrine, from 20 operating rooms and refrigerators where the unused drugs were stored. Each drug was divided into two groups, the pre-use group and the post-use group. The pre-use drugs were cultured before the patient received the drug. The post-use drugs were cultured after the patient had received the drug or after the drugs had been transferred to other syringes. The culture results were reported as either positive or negative.Results: Out of the 945 drug samples, 26 (2.8%, 95% confidence interval=1.8%-4.0%) gave a positive culture. Of the 317 propofol samples, 20 (6.3%) were found to have bacterial contamination, 11 in the pre-use group and 9 in the post-use group. Of the 318 ephedrine samples, 6 (1.9%) were found to be positive on culture, one in the pre-use group and five in the post-use group. Vecuronium gave no positive cultures. All organisms were non-pathogenic, and no fungal contamination was found. Conclusion:The incidence of bacterial contamination in anaesthetic and vasopressor drugs was 2.8%. Anaesthetic teams must be aware of contamination issues in anaesthetic drugs that have been prepared for later use and, in order to reduce the risk of contamination, they must improve the methods of administering drugs to patients.Keywords: Anaesthetic drug, contamination, operating room, sterility Abstract Address for Correspondences: Panthila Rujirojindakul

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Section: Discussionsupporting

confidence: 83%

Bacterial Contamination of Anaesthetic and Vasopressor Drugs in the Operating Theatres

Rueangchira-urai¹,

Rujirojindakul²,

Geater³

et al. 2017

Turk J Anaesth Reanim

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“…In the present study, the contamination rate in MDVVs was much lower than the rates reported for MDVs in hospital settings of Iran (approximately 5%) (13,14). MDVs used in hospital settings are normally kept in the immediate patient treatment area, and inadvertent contamination of the vial is more likely to happen through direct or indirect contact with potentially contaminated surfaces or equipments (14).…”

Section: Discussioncontrasting

confidence: 53%

“…MDVs used in hospital settings are normally kept in the immediate patient treatment area, and inadvertent contamination of the vial is more likely to happen through direct or indirect contact with potentially contaminated surfaces or equipments (14). It has been well documented that poor aseptic techniques employed during successive applications of MDVs may result in serious and life-threatening infections in hospital settings (18).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the data from 2 Iranian studies (13,14) indicating the prevalence of bacterial contamination of MDVs (approximately 5%), the sample size was estimated at 3640 vials (α, 0.05; β, 0.2; d, 0.01) while considering the effect of the study design. We included all urban health centres and health posts in Zahedan, Southeast of Iran.…”

Section: Setting and Sample Size Calculationmentioning

confidence: 99%

“…The highest contamination rate was reported in vials, used in the interventional bronchoscopy unit, and Staphylococcus epidermidis was identified as the most frequently isolated pathogen (14). However, contamination rates of 1% or lower have been reported for multiple use vials in Iran, as well as some developed countries (15,16).…”

Section: Introductionmentioning

confidence: 99%

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A Study on Bacterial Contamination of Multidose Vaccine Vials in Southeast of Iran

et al. 2017

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Background: Contaminated multipledose vaccine vials (MDVVs) have been implicated in the outbreaks of pyogenic abscesses and other bacterial infections. In this study, we aimed to investigate the prevalence of bacterial contamination of MDVVs. Methods: Over 3 months, a total of 3640 in-use MDVVs were collected from 39 urban health centres and health posts in Zahedan, southeast of Iran and inoculated on appropriate bacterial growth media. The bacteria were identified using the methods described by the American type culture collection (ATCC). Results: Bacterial contamination was identified in 6 out of 3640 (0.2%) MDVVs. The isolated microorganisms included Staphylococcus epidermidis (3 vials), Staphylococcus saprophyticus (2 vials), and Escherichia coli (1 vial). Conclusions:The present results revealed some breaches in safe injection practices and noncompliance with aseptic techniques in vaccination services provided by urban health centres and health posts. This article highlights the importance of basic infection control training and the need for increased awareness of safe injection practices among healthcare workers.

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Guideline Implementation: Medication Safety

Burlingame¹

2018

AORN Journal

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Microbial contamination of single- and multiple-dose vials after opening in a pulmonary teaching hospital

Cited by 16 publications

References 21 publications

Bacterial Contamination of Anaesthetic and Vasopressor Drugs in the Operating Theatres

Bacterial Contamination of Anaesthetic and Vasopressor Drugs in the Operating Theatres

A Study on Bacterial Contamination of Multidose Vaccine Vials in Southeast of Iran

Guideline Implementation: Medication Safety

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