Antibiotics produced by Streptomyces

Procópio, Rudi Emerson de Lima; Silva, Ingrid Reis da; Martins, Mayra Kassawara; Azevedo, João Lúcio de; Araújo, Janete Magalí de

doi:10.1016/j.bjid.2012.08.014

Cited by 501 publications

(211 citation statements)

References 49 publications

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“…The image showed that the smooth-surfaced spores are held in straight chains (rectiflexibiles) ( Figure 1B). 47,48 The morphological characteristics of the strain Ess_amA-1 were further substantiated by physiological and biochemical tests. The results of the physiological and biochemical characteristics are summarized in Tables 1 and 2.…”

Section: Discussionmentioning

confidence: 99%

Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

Ahmad¹,

Yasser²,

Sholkamy³

et al. 2015

IJN

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Selenium is an important component of human diet and a number of studies have declared its chemopreventive and therapeutic properties against cancer. However, very limited studies have been conducted about the properties of selenium nanostructured materials in comparison to other well-studied selenospecies. Here, we have shown that the anticancer property of biostabilized selenium nanorods (SeNrs) synthesized by applying a novel strain Ess_amA-1 of Streptomyces bikiniensis . The strain was grown aerobically with selenium dioxide and produced stable SeNrs with average particle size of 17 nm. The optical, structural, morphological, elemental, and functional characterizations of the SeNrs were carried out using techniques such as UV-vis spectrophotometry, transmission electron microscopy, energy dispersive X-ray spectrometry, and Fourier transform infrared spectrophotometry, respectively. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed that the biosynthesized SeNrs induces cell death of Hep-G2 and MCF-7 human cancer cells. The lethal dose (LD 50% ) of SeNrs on Hep-G2 and MCF-7 cells was recorded at 75.96 μg/mL and 61.86 μg/mL, respectively. It can be concluded that S. bikiniensis strain Ess_amA-1 could be used as renewable bioresources of biosynthesis of anticancer SeNrs. A hypothetical mechanism for anticancer activity of SeNrs is also proposed.

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Section: Discussionmentioning

confidence: 99%

Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

Ahmad¹,

Yasser²,

Sholkamy³

et al. 2015

IJN

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“…Microorganisms are attractive resources to synthesize structurally-diverse substances with various bioactivities that may be used as effective drugs or act as drug lead compounds that could be further modified and developed for higher efficacy [1]. Within the domain bacteria, actinomycetes showed unprecedented ability to produce potentially novel, clinically useful, secondary metabolites with anticancer, antioxidant, antiviral, and antibacterial compounds, the majority of these being derived from the members of the Streptomyces genus that include different classes of antibiotics including aminoglycosides, macrolides, and Beta-lactams [2].…”

Section: Introductionmentioning

confidence: 99%

Optimization, Isolation and Characterization of Bioactive Compounds From Streptomyces Lavendulocolor VHB-9

Bssn

Munaganti

Vijayalakshmi

et al. 2018

Asian J Pharm Clin Res

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Objectives: Optimization, isolation, and characterization of bioactive compounds from Streptomyces lavendulocolor VHB-9 isolated from granite mines of Mudigonda village of Khammam district of Telangana state. Methods:The potent strain was identified as S. lavendulocolor VHB-9 by polyphasic taxonomy. The influence of culture conditions on growth and bioactive compounds production was investigated. Purification of bioactive compounds was done using column chromatography. The structures of the compounds were elucidated on the basis of spectroscopic analysis including Fourier transform infrared, electron spray ionization mass spectrophotometry, 1 H nuclear magnetic resonance (NMR), and 13 C NMR. The antimicrobial activity of the compounds produced by the strain was tested against both Gram-positive and Gram-negative bacteria and fungi in terms of minimum inhibitory concentration.Results: Isolation and identification of two compounds, namely (2R, 3R)-2, 3-Butanediol (B1A), and nonadecanoic acid (B1B). Fraction B4 was isolated partially purified fraction and identified by the gas chromatography-mass spectrometry analysis. B1B compound exhibited the highest activity against Bacillus megaterium, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans when compared to B1A and B4 compounds.

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“…The primary natural reservoir of microorganisms (bacteria, and fungi) capable of synthesizing antibiotics is the soil. Streptomyces (actinomycetes), which are generally soil bacteria, produce 70% of the already known antibiotics [10][11]. Antibiotics are produced also by other bacteria, such as Bacillus polymyxa, B. licheniformis, and Pseudomonas fluorescens, and by fungi, e.g., Penicillium chrysogenum, Fusidium coccineum, and F. griseum [12].…”

Section: Introductionmentioning

confidence: 99%

Diversity of Antibiotic Resistance Among Bacteria Isolated from Sediments and Water of Carp Farms Located in a Polish Nature Reserve

Piotrowska¹,

Rzeczycka²,

Ostrowski³

et al. 2017

Pol. J. Environ. Stud.

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The present study collected bacterial samples from water and bottom sediments from fish farms located in a nature reserve area in Poland with no recorded history of antibiotic use. The aim of the study was to determine the initial states of tetracycline, streptomycin, and erythromycin resistance before a potential increase of intensive aquaculture and application of antimicrobial agents in that region. With this in mind, the diversity and antibiotic resistance phenotypes and genotypes of isolates from the bottom sediments and water in five of the 13 fish ponds in Raszyn were evaluated. A total of 58 (sediment, n = 24; water, n = 34) non-repetitive and non-susceptible isolates were affiliated to 14 genera. Among the sediment isolates, Pseudomonas spp. and Bacillus spp. were isolated most frequently, and from the water, Stenotrophomonas spp. and Pseudomonas spp. Phenotypically resistant isolates selected by disk diffusion were further screened by polymerase chain reaction (PCR) and amplicon sequencing. The isolates derived from the water showed a greater percentage of phenotypically resistant isolates to each of the three antibiotics. The most common tetracycline resistant genes detected in isolates from both the water and sediment were tet(A), tet(T), tet(W), and tet(34). On the other hand, the genes tet(X), tet(H), tet(M), and tet(BP) were the most frequent among sedimentary isolates, while tet(B), tet(C), tet (D), and tet(32) were prevalent in aquatic isolates. The most prevalent streptomycin resistance genes among the aquatic isolates were aac(6')-I, str(A), and str(B). The erythromycin resistance genes detected in all isolates included msr(A), erm(X), erm(V), erm(F), and erm(E).

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Antibiotics produced by Streptomyces

Cited by 501 publications

References 49 publications

Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

Optimization, Isolation and Characterization of Bioactive Compounds From Streptomyces Lavendulocolor VHB-9

Diversity of Antibiotic Resistance Among Bacteria Isolated from Sediments and Water of Carp Farms Located in a Polish Nature Reserve

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