Paracoccidioidomycosis in pregnancy: an atypical case report

Pereira, Cláudio Maranhão; Gasparetto, Patrícia Freire; Alves, Virgínia Farias; Guidi, Rafaela; Botelho, Tessa de Lucena

doi:10.1016/j.bjid.2012.08.007

Cited by 5 publications

(2 citation statements)

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“…In this context, antiviral, antifungal or antiparasitic responses can be affected when CD4 +, CD8 + and NK T lymphocytes present impaired functions, making it difficult to eliminate the offending microorganism 40 . Interestingly, the 38‐year‐old patient included in this study had a premature labour at 8 months 39 …”

Section: Discussionmentioning

confidence: 98%

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Oral Paracoccidioidomycosis affecting women: A systematic review

Costa

Carvalho

Sperandio

et al. 2020

Mycoses

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Paracoccidioidomycosis (PCM) is an infection caused by fungi of the genus Paracoccidioides and is marked by a strong predilection for men; nevertheless, some women have had developed PCM and have presented oral involvement by the disease. Objectives: To review all published cases until August 2020 of oral PCM in women, with emphasis on the presence of systemic changes, deleterious habits (tobacco and alcohol) and oral manifestation features through a systematic review. Methods: Observational studies (both prospective and retrospective) and case reports indexed in the Embase, PubMed, Scopus, Web of Science and LIVIVO databases were selected by two reviewers in a two‐phase process following the pre‐established PICOS criteria. Results: Twenty‐five studies met the eligibility criteria and were selected for qualitative synthesis, of which 72 participants were enrolled. Brazilian White women between 40 and 50 years were the most affected and social history revealed them to be housewives or rural workers. Fifteen women (33.3% of the informed cases) presented any systemic change at the time of PCM diagnosis, namely pregnancy, HIV infection and/or depression. Moriform stomatitis was predominant and affected preferentially the gingivae and alveolar processes in the form of a single painful lesion. Most patients were treated with sulfamethoxazole + trimethoprim or itraconazole. Conclusions: Oral PCM in women is rare; some cases showed systemic changes at the time of PCM diagnosis, namely HIV infection, pregnancy and depression. New studies should be conducted to elucidate the influence of systemic alterations on the development of oral PCM in women.

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Section: Discussionmentioning

confidence: 98%

“…Pregnancy was also a frequent systemic change, affecting two women, aged 25 and 38 years 34,39 . The third trimester of pregnancy is reported as a risk factor for the occurrence of serious fungal diseases 40 .…”

Section: Discussionmentioning

confidence: 99%