Lyme disease in the state of Tocantins, Brazil: report of the first cases

Carranza-Tamayo, César Omar; Costa, José Nilton Gomes da; Bastos, Whisllay Maciel

doi:10.1016/j.bjid.2012.07.013

Cited by 20 publications

(13 citation statements)

References 18 publications

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“…In Colombia, a study on 20 serum samples from patients with signs of Lyme borreliosis showed that only four fulfilled the CDC WB criteria 55 . A similar situation occurred in Brazil, where despite positive IgM serology, only one of the cases gave a positive WB, and it was undetermined in another 56 . Studies using a battery of primers to detect B.b.…”

Section: Borreliosis In Latin Americamentioning

confidence: 51%

Borrelia Infection in Latin America

Robles

Fong

Cervantes

2018

RIC

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Lyme disease (LD) is a multisystemic inflammatory disease caused by pathogenic spirochetes, belonging to the genospecies complex Borrelia burgdorferi sensu lato (B.b.s.l.). Around the world, distinct species of Ixodes tick vectors transmit different species of Borrelia. Despite the rising recognition and occurrence of tick-borne disease in Latin America, serology has proven to be inconclusive in detecting suspected LD cases. Recently, new B.b.s.l. strains or new related species have been described in Brazil, Uruguay, and Chile. This could explain the lack of confirmatory tests, such as indeterminate Western blots (WBs) and polymerase chain reactions, in detecting suspected LD cases in this region of the world. Future studies will need to determine the extension of novel B.b.s.l. species infections in ticks, reservoirs, and humans in Latin America. The existence of these new Borrelia genomic species should prompt the development of innovative diagnostic and clinical approaches.

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Section: Borreliosis In Latin Americamentioning

confidence: 51%

Borrelia Infection in Latin America

Robles

Fong

Cervantes

2018

RIC

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“…Varios reportes en Sudamérica han mostrado que, a pesar de mostrar un resultado de ELISA positivo, muchos casos de presunta enfermedad de Lyme no logran alcanzar el criterio de Western blot para ser considerados positivos (54)(55)(56)(57) . Esto llevó a sugerir la hipótesis de la existencia de una nueva cepa local de B.b.s.l., antigénicamente distinta de la cepa americana B31, que es usualmente utilizada como fuente antigénica para los exámenes de diagnóstico (50) .…”

Section: Sudaméricaunclassified

Enfermedad de Lyme en el Perú. Una revisión clínica y epidemiológica

Cervantes

2018

Rev Peru Med Exp Salud Publica

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This is a critical and organized review of all the available and updated information on Lyme disease and Borrelia infection in Peru. Several studies of positive serology to Borrelia burgdorferi and several cases of Lyme disease have been reported in Peru in the last two decades. New information suggests that new species of Borrelia burgdorferi sensu lato do exist in South America, and possibly in Peru. Future genetic and microbiology studies in this part of the continent, not only in cases with an indeterminate Western blot but in vectors and possible reservoirs as well, are necessary to measure the extent and clinical implications of these new Borrelia species.

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“…Because of differences in the clinical syndrome and vectors present in the region, LD in Brazil is also known as LD-like syndrome or Baggio-Yoshinari syndrome (BYS) (MANTOVANI et al, 2007). Although several human cases have been described throughout the country (YOSHINARI et al, 2003(YOSHINARI et al, , 2007CARRANZA-TAMAYO et al, 2012;ROSA et al, 2014), Borrelia spp. have not yet been isolated or characterized from such cases and Borrelia infection in humans remains to be confirmed in Brazil (YOSHINARI et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Serosurvey of Borrelia in dogs, horses, and humans exposed to ticks in a rural settlement of southern Brazil

Nascimento

Vieira

et al. 2016

Rev. Bras. Parasitol. Vet.

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The aims of the present study were to serosurvey dogs, horses, and humans highly exposed to tick bites for anti-Borrelia burgdorferi s.l. antibodies, identify tick species present, and determine risk factors associated with seropositivity in a rural settlement of Paraná State, southern Brazil. Eighty-seven residents were sampled, along with their 83 dogs and 18 horses, and individual questionnaires were administered. Immunofluorescence antibody test (IFAT) was performed on serum samples and positive samples were subjected to western blot (WB) analysis. Anti-B. burgdorferi antibodies were found in 4/87 (4.6%) humans, 26/83 (31.3%) dogs, and 7/18 (38.9%) horses by IFAT, with 4/4 humans also positive by WB. Ticks identified were mostly from dogs and included 45/67 Rhipicephalus sanguineus, 21/67 Amblyomma ovale, and 1/67 A. cajennense sensu lato. All (34/34) horse ticks were identified as A. cajennense s.l.. No significant association was found when age, gender, or presence of ticks was correlated to seropositivity to Borrelia sp. In conclusion, although anti-Borrelia antibodies have been found in dogs, horses and their owners from the rural settlement, the lack of isolation, molecular characterization, absence of competent vectors and the low specificity of the commercial WB kit used herein may have impaired risk factor analysis.

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Lyme disease in the state of Tocantins, Brazil: report of the first cases

Abstract: Lyme disease is an underdiagnosed zoonosis in Brazil. There are no cases registered in the state of Tocantins, the newest Brazilian state. The cases of three patients in contact with rural areas in three Tocantins' districts are herein described, and the Brazilian literature is reviewed.

Cited by 20 publications

References 18 publications

Borrelia Infection in Latin America

Borrelia Infection in Latin America

Enfermedad de Lyme en el Perú. Una revisión clínica y epidemiológica

Serosurvey of Borrelia in dogs, horses, and humans exposed to ticks in a rural settlement of southern Brazil

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