Lack of association between Kidd blood group system and chronic kidney disease

Abstract

BackgroundThe Kidd blood group system has three antigens, Jka, Jkb and Jk3, found on red blood cells and on endothelial cells of the inner lining of blood vessels in the renal medulla. These are known as urea transporter B (UT-B). Researchers have found that individuals carrying the Jk(a − b−) or Jk-null (UT-B null) phenotypes have a lower urine-concentrating capability and risk of severe renal impairment. This study evaluated the distribution of the Kidd phenotypes in patients with chronic kidney disease and a possible association of Kidd antigens with the development of renal disease.MethodsJka and Jkb antigens were phenotyped using the gel column agglutination test (ID-cards Bio-RAD) in 197 patients with chronic kidney disease and 444 blood donors, as the control group. The phenotype and antigen frequencies between patients and controls were evaluated using the Chi-square method with Yates correction and logistic regression after adjustments for gender and age.ResultsNo differences were observed between the Kidd phenotypes frequency distribution between patients with chronic kidney disease and blood donors [Jk(a − b+) = 22.3% and 27.2%; Jk(a + b−) = 30.5% and 24.3%; Jk(a + b+) = 47.25% and 48.4%, respectively].ConclusionThe distribution of Kidd phenotypes found in the studied population is expected for Caucasians; Jka and Jkb antigens and phenotypes were not found to be related to susceptibility for chronic kidney disease.

Investigation of facilitative urea transporters in the human gastrointestinal tract

“…In contrast, a recent study found no link between UT‐B and human kidney disease (Capriolli et al. ). The potential influence of UT‐B variation on gastrointestinal diseases has yet to be investigated, but should now be as a matter of some urgency.…”

The safety of kidd-incompatible blood transfusion in a restricted setting: a case report

“…Kidd antigens are inherited in codominant patterns, while Jk null phenotype is generally inherited recessively. 13 Evaluating the benefit and risk of going ahead with the transfusion, the patient was finally decided to be given blood transfusion with the least incompatibility which was from his brother. It is understood that having a donor from family member is actually less preferable compared to unrelated donors -as homozygosity of HLA types is more common to occur between first-degree family members, which may trigger transfusion-associated graft-versus-host-disease (TA-GVHD).…”

Kidd system antigens and kidney disease

“…Caprioli et al, 4 found no difference in phenotype frequencies or the distribution of Jka and Jkb antigens when they compared patients with chronic kidney disease and controls, however the null phenotype was not observed in the groups. This suggests that the absence of Jka or Jkb does not influence the development of chronic kidney disease in these chronic kidney disease patients, although the influence of the absence of both has not been studied.…”

“…The paper by Caprioli et al 4 published in this issue of the Revista Brasileira de Hematologia e Hemoterapia investigates possible relations between the absence of Jka or Jkb antigens in patients with chronic kidney disease. This is interesting because individuals with the Jk (a-b-) phenotype had lower urine-concentrating ability, however if patients with chronic kidney disease present some difference in the Kidd phenotype, the distribution remains unknown.…”