Bone marrow transplant donor recruitment strategies to maximize, optimize, and equalize recipient chances of an acceptable match

Pôrto, Luís Cristóvão

doi:10.1016/j.bjhh.2016.12.002

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…For the recruitment of new donors, the chance of finding a compatible donor should take into account the distribution of the haplotypes. Therefore, the number of new donors should be limited in campaigns in those cities with less than 20 000 inhabitants and low migration rates, in order to avoid duplicate entries related to the family genetic background, resulting in a more effective strategy to find potential donors …”

Section: Bone Marrow Donors and Other Studies In Urban Populationsmentioning

confidence: 99%

“…Therefore, the number of new donors should be limited in campaigns in those cities with less than 20 000 inhabitants and low migration rates, in order to avoid duplicate entries related to the family genetic background, resulting in a more effective strategy to find potential donors. 52 It is important to emphasize the difference in the pattern of HLA diversity found between Native American and urban populations, such as those that compose the REDOME database. Native American populations have a reduced number of alleles-and in high frequency-and low genetic diversity due to strong genetic drift associated to their small population size and isolation.…”

Section: Bone Marrow Donors and Other Studies In Urban Populationsmentioning

confidence: 99%

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HLA diversity in Brazil

Boquett

Bisso‐Machado

Zagonel-Oliveira

et al. 2019

HLA

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Brazil is the fifth largest country in the world in area and the fifth most populous. The Brazilian voluntary Bone Marrow Donor Registry is the third largest in terms of number of donors in the world, being a valuable source of HLA genetics to characterize the donor population of Brazil as well. The genetic background of the Brazilian population is quite heterogeneous, resulting from 5 centuries of admixture among Native Americans, Europeans and Africans, making the Brazilian population unique in terms of genetic ancestry. The unique characteristics of populations in different Brazilian regions make them an exciting focus for genetic diversity studies. Studies on HLA genetic diversity of Brazilian populations have been conducted since the late 1980s and, in this review, we highlight the main findings from studies carried out in Brazil based on classical HLA. In addition, we calculated the genetic distance from the molecular data of the studies included in this review in order to have a broader view of the HLA diversity in Brazilian populations. We emphasize that characterization of HLA diversity is not only important for transplantation programs, but can shed a light on ancestry, history and other demographic patterns with or without association with autoimmune disease.

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Section: Bone Marrow Donors and Other Studies In Urban Populationsmentioning

confidence: 99%

Section: Bone Marrow Donors and Other Studies In Urban Populationsmentioning

confidence: 99%

HLA diversity in Brazil

Boquett

Bisso‐Machado

Zagonel-Oliveira

et al. 2019

HLA

View full text Add to dashboard Cite

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The distribution of HLA haplotypes in the ethnic groups that make up the Brazilian Bone Marrow Volunteer Donor Registry (REDOME)

et al. 2018

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The Registries of Bone Marrow Donors around the world include more than 30 million volunteer donors from 57 different countries, and were responsible for over 17,000 hematopoietic stem cell transplants in 2016. The Brazilian Bone Marrow Volunteer Donor Registry (REDOME) was established in 1993 and is the third largest registry in the world with more than 4.3 million donors. We characterized HLA allele and haplotypes frequencies from REDOME comparing them with the donor self-reported race group classification. Five-locus haplotype frequencies (A~C~B~DRB1~DQB1) were estimated for each of the six race groups, resolving phase and allelic ambiguity using the expectation-maximization (EM) algorithm. The top 100 haplotypes in the race groups were separated into eight clusters of haplotypes, based on haplotype similarity, using CLUTO. We present HLA allele and haplotype frequency data from six race groups from 2,938,259 individuals from REDOME. The most frequent haplotype was the same for all groups: A*01:01g~C*07:01g~B*08:01g~DRB1*03:01g~DQB1*02:01g. Some frequent haplotypes such as A*02:01g~C*16:01g~B*44:03~DRB1*07:01g~DQB1*02:01g was not found in people with Preta (Sub-Saharan African descent). A cluster including Branca (European) and Parda or non-informed (admixed) could be distinguished from both Preta (SubSaharan) and Indígena (Amerindian) groups, and from the Amarela (Asian) ones, which clustered with their original population. These results have implications on cross-population matching and can help in donor searches and population-based recruitment strategies.

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