Differential admixture, human leukocyte antigen diversity, and hematopoietic cell transplantation in Latin America: challenges and opportunities

Arrieta-Bolaños, Esteban; Oliveira, Danielli C. M.; Barquera, Rodrigo

doi:10.1038/s41409-019-0737-4

Cited by 10 publications

(9 citation statements)

References 62 publications

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“…Despite over 36 million stem cell donors listed on registries in 54 countries around the world, 4 many patients remain unable to find a suitable unrelated donor. This is especially true for patients from ethnic/ racial minority groups both within and outside North America, [5][6][7][8][9][10][11][12][13] who face lower rates of finding HLAmatched donors due to a combination of smaller donor pools, disproportionate representation on individual registries and on the worldwide network, and ethnic/ racial differences in genetic diversity and in attrition rates from donor registries. [14][15][16][17] Alongside the need for ethnic diversity on donor registries, young and male donors are preferred by transplant physicians due to their associations with improved outcomes in transplant recipients.…”

Section: Introductionmentioning

confidence: 99%

Multimedia resources to support the recruitment of committed hematopoietic stem cell donors: Perspectives of the most‐needed donors

Lee

Vaseghi‐Shanjani

et al. 2020

Transfusion

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Background: Recruitment of committed unrelated hematopoietic stem cell donors from the most-needed demographics remains a challenge for donor recruitment organizations worldwide. Multimedia resources are gaining attention as a modality to support recruitment efforts; however, there is a lack of guidance for the development of such tools. This qualitative study explores the perspectives of eligible stem cell donors on an educational whiteboard video about stem cell donation, generating insights into how whiteboard videos and related multimedia may be optimized for donor recruitment. Study Design and Methods: Eight semistructured focus groups were conducted with 38 potential donors from the most-needed demographics (young, male, and non-Caucasian) after they had watched a 3.5-minute whiteboard video explaining key concepts in stem cell donation (https://youtu.be/ V4fVBtxnWfM). Constructivist grounded theory was used to identify themes and to develop a framework for understanding participants' preferred features of recruitment multimedia. Results: Participants identified a range of features contributing to the effectiveness of recruitment multimedia, adding that the whiteboard video is an effective, integrated, and readily accessible format for supporting donor recruitment. Topics that participants felt are important to address include knowledge gaps regarding donation procedures, concerns about donor safety, and the particular need for specific donor demographics. Suggested avenues for improvement include the addition of donor/recipient/patient personal experiences, attention-grabbing hooks, and a call to action including opportunities for further learning.

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Section: Introductionmentioning

confidence: 99%

Multimedia resources to support the recruitment of committed hematopoietic stem cell donors: Perspectives of the most‐needed donors

Lee

Vaseghi‐Shanjani

et al. 2020

Transfusion

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“…After studying HLA typing across different regions worldwide, including Mexico and other Latin American countries, it has been shown that the frequency of antigens varies from one population to another 5,6 . The number of polymorphisms identified in the HLA in different populations reflects the "evolutionary pressure" on the immune system that can be exerted by infectious diseases 7 .…”

Section: Discussionmentioning

confidence: 99%

HLA alleles and haplotypes in a population from the northeast of Mexico treated at the blood and bone marrow transplant center of the hematology service of a university hospital

Mancı́as-Guerra¹,

Velasco-Ruiz²,

Cordero-Leija³

et al. 2023

RMU

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Objective: Human immune recognition of self and foreign is partially controlled by a set of genes in the human leukocyte antigen complex (HLA). HLA is the most polymorphic region in the human genome, and it is used to assure compatibility between donor and recipient for hematopoietic stem cell transplantation. There are six "classical" HLA genes encoding highly polymorphic loci: HLA-A, B, and C (Class I major histocompatibility complex), and HLA DR, DQ, and DP (Class II). This study aims to quantify the frequency of HLA A, B, C, DRB1, and DQB1 alleles taken in a transplant center in the northeastern part of Mexico. Methods: Descriptive and retrospective data of HLA typing by polymerase chain reactions-SSP for class I and II HLA in our Institution were analyzed. Tests for HLA-A, B, C, DRB1, and DQB1 were performed in 1614 patients. The number of haplotypes found was 726. Results: The most common combinations were A*02, B*35, C*04, DRB1*08, and DQB1*04, which were observed 38 times (5.2%). Conclusion: The most frequent HLA alleles were HLA-A2 and HLA-DQ 03, respectively, with a frequency of 0.2961 and 0.2758.

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“…Another concern is the choice of bone marrow donors as a control population given that recruitment bias is inherent to this group 18,37 . However, REDOME is the third largest bone marrow donor registry database in the world and one of the largest repositories documenting HLA diversity 38,39 . Furthermore, any other volunteer recruitment method capable of gathering the thousands of subjects needed to test the wide variety of HLA alleles by the NGS technique would probably result in the same bias.…”

Section: Discussionmentioning

confidence: 99%

HLA alleles and antiseizure medication‐induced cutaneous reactions in Brazil: A case‐control study

Tensini

Paola

Boldt

et al. 2023

HLA

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In this observational case–control study, 107 cutaneous adverse reaction (CAR) cases (CAR+) manifesting up to 12 weeks after the start of treatment with antiseizure medication (ASM) were identified. Control groups consisted of 98 epilepsy patients without a history of CAR (CAR‐) and 3965 healthy individuals in the Brazilian National Registry of Bone Marrow Donors. All participants were HLA typed by high‐resolution Next Generation Sequencing for HLA‐A, B, C, DQB1 and DRB1; HLA‐DPA1, DPB1, DQA1, DRB3, DRB4 and DRB5 were also sequenced in samples from CAR+ and CAR‐ individuals. The relationship between the carrier frequency of each allele, CAR type and ASM for all participants was investigated. The ASMs most frequently associated with CAR were carbamazepine (48% of CAR+ subjects), lamotrigine (23%), phenytoin (18%), phenobarbital (13%) and oxcarbazepine (5%). The main alleles associated with a risk of CAR were HLA‐A*02:05 (OR = 6.28; p = 0.019, carbamazepine or oxcarbazepine); HLA‐DPA1*02:02 (OR = 4.16, p = 0.003, carbamazepine); HLA‐B*53:01 (OR = 47.9, p = 0.014, oxcarbazepine), HLA‐DPA1*03:01/DPB1*105:01 (OR = 25.7, p = 0.005, phenobarbital); HLA‐C*02:10 (OR = 25.7, p = 0.005, phenobarbital) and HLA‐DRB1*04:02 (OR = 17.22, p = 0.007, phenytoin). HLA‐A*03:01 increased the risk for phenytoin‐induced maculopapular exanthema 4.71‐fold (p = 0.009), and HLA‐B*35:02 was associated with a 25.6‐fold increase in the risk of carbamazepine‐induced Stevens‐Johnson syndrome (p = 0.005). None of the 4170 subjects carried the HLA‐B*15:02 allele, and HLA‐A*31:01 was not associated with CAR. Hence, HLA‐A*31:01 and HLA‐B*15:02 were not associated with CAR in this population. Although other HLA class I and II alleles tested were associated with a risk of CAR, none of these associations were strong enough to warrant HLA testing before prescribing ASM.

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Differential admixture, human leukocyte antigen diversity, and hematopoietic cell transplantation in Latin America: challenges and opportunities

Cited by 10 publications

References 62 publications

Multimedia resources to support the recruitment of committed hematopoietic stem cell donors: Perspectives of the most‐needed donors

Multimedia resources to support the recruitment of committed hematopoietic stem cell donors: Perspectives of the most‐needed donors

HLA alleles and haplotypes in a population from the northeast of Mexico treated at the blood and bone marrow transplant center of the hematology service of a university hospital

HLA alleles and antiseizure medication‐induced cutaneous reactions in Brazil: A case‐control study

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