Red cell autoantibody mimicking anti-C specificity: a rare manifestation

Subramaniyan, Rajeswari; Veerasamy, Mangalakumar

doi:10.1016/j.bjhh.2016.11.002

Cited by 2 publications

(2 citation statements)

References 4 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most patients, autoantibodies react with all RBCs resulting in agglutination; however, some patients have autoantibodies with no apparent specificity in RBC panel tests, representing the most striking feature of mimicking antibodies. [1][2][3][4] In this study, we report the discovery of autoantibodies mimicking anti-Rh(e) specificity in a patient with suspected autoimmune hemolytic anemia. The mimicking antibody was detected in the patient's plasma and RBC eluate.…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Serological analysis of autoantibody mimicking anti-Rh(e) specificity: a case report

Dong,

Huang,

Ying

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

Mimicking antibodies are described as autoantibodies with the “wrong” specificity, possessing both specificity and panreactivity. We report the case of a female patient with suspected hemolytic anemia in whom an autoantibody mimicking anti-Rh(e) specificity was found in both plasma and red blood cell samples. Mimicking antibodies are not usually identified in the clinic; however, it is still necessary to determine the specificity of mimicking antibodies to avoid antigen-positive blood transfusions and achieve maximum transfusion compatibility.

show abstract

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Serological analysis of autoantibody mimicking anti-Rh(e) specificity: a case report

Dong,

Huang,

Ying

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

show abstract

Eleven years of alloimmunization in 6496 patients with sickle cell disease in France who received transfusion

Floch,

Viret,

Malard

et al. 2023

Blood Advances

View full text Add to dashboard Cite

Red blood cell (RBC) transfusion is a major therapy for sickle cell disease (SCD). Patients are at risk of forming antibodies to RBC antigens which can result in the impossibility to find compatible units and cause hemolytic transfusion reactions. This retrospective study investigates the evolution of RBC consumption, the frequencies, specificities and chronology of appearance of antibodies in a population of patients consistently receiving RH-K matched RBC units (RBCu) from a predominantly European donor population. Over the 11 year period in the Paris area, 6496 patients were transfused at least once for a total of 239944 units. Antibodies were made by 1742 patients. The first antibodies of a patient were predictive of subsequent immunization. By the 17th RBC unit transfused (by the 20th, excluding warm autoantibodies), 75% of patients who would make antibodies had made their first. By the 16th, 90% who would make antibodie(s) to a high frequency antigen had made their first antibody to these antigens. Females made their first antibodies slightly earlier than males. Multitransfused patients (>50 units) had a higher immunization prevalence than rarely transfused patients (<12 units) but fewer clinically significant antibodies. Patients with SCD and prophylactic RH-K matching not immunized by the 20th RBCu are likely to have a low alloimmunization risk (to antigens other than RH-K), i.e. be low responders, especially relative to the most clinically significant antibodies. This number of 20 units is a point before which close monitoring of patients is most important, but remains open to future adjustment.

show abstract

Red cell autoantibody mimicking anti-C specificity: a rare manifestation

Cited by 2 publications

References 4 publications

Serological analysis of autoantibody mimicking anti-Rh(e) specificity: a case report

Serological analysis of autoantibody mimicking anti-Rh(e) specificity: a case report

Eleven years of alloimmunization in 6496 patients with sickle cell disease in France who received transfusion

Contact Info

Product

Resources

About