Complete blood count alterations in disseminated histoplasmosis

Lunardi, Luciano Werle; Wagner, Ralf; Santos, Cintia Cichowski dos; Severo, Adriane Turconi; Ferreira, Jorge Alberto Santiago

doi:10.1016/j.bjhh.2015.03.006

Cited by 2 publications

(2 citation statements)

References 3 publications

(8 reference statements)

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“…Alterations in the Complete Blood Count (CBC), such as anaemia, leukopenia, or pancytopenia, are common in disseminated histoplasmosis, reflecting its systemic impact. Since CBC is a routine test that provides an overview of a patient's health, its alterations in histoplasmosis cases are significant for diagnosis and management ( 6 ). Culturing H. capsulatum is the definitive diagnostic approach, yet in our case, the diagnosis was initially identified through bone marrow studies.…”

Section: Discussionmentioning

confidence: 99%

“…Histoplasmosis presents in three primary forms: acute pulmonary, chronic pulmonary, and progressive disseminated ( 5 ). While the acute and chronic pulmonary types may resolve without specific intervention, the progressive disseminated form is critical and requires prompt treatment with systemic anti-fungals ( 6 ). Relapses, occurring in 10–20% of immunocompetent patients and up to 80% in HIV-positive patients, necessitate continued treatment ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic insights into disseminated histoplasmosis: a case report highlighting bone marrow analysis

Kaushik,

Khanna,

Khanna

et al. 2024

IJM

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We present a case of a 43-year-old immunocompromised female patient diagnosed with disseminated histoplasmosis on bone marrow examination, at clinical laboratory of Kasturba Hospital, Manipal, Karnataka, India. The patient, presenting with symptoms like weight loss, appetite loss, and pancytopenia, underwent bone marrow aspiration and biopsy. The bone marrow studies revealed HIV-associated changes and the yeast form of Histoplasma capsulatum, confirming disseminated histoplasmosis. Bone marrow examination is highlighted as a diagnostic tool with significant sensitivity in such cases. The report stresses on the importance of awareness and early diagnosis of histoplasmosis in immunocompromised patients, given its potential lethality and the need for timely therapeutic intervention for better prognosis.

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Section: Discussionmentioning

confidence: 99%