A Critical Review of Diagnostic Methods for Disseminated Histoplasmosis with Special Focus on Resource-Limited Settings

Ekeng, Bassey E.; Emanghe, U. E.; Davies, Adeyinka A.; Oladele, Rita O.

doi:10.1007/s12281-023-00454-4

Cited by 1 publication

(2 citation statements)

References 67 publications

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“…Xingqin Huang 2 Fang Long 3 Enle Wang 4 Yan Xi 5 Yun Zhang 6 1 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing,…”

Section: Funding Informationmentioning

confidence: 99%

“…Bassey Ekeng et al recently indicated that the application of blood smear could be an important diagnostic tool for disseminated histoplasmosis in resource-limited settings. 6 Case 6 was an unusual Talaromyces marneffei infection in HIVinfected child. In the majority situation, Talaromyces marneffei primarily affects patients infected with HIV and occasionally with immunocompromising conditions.…”

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Critical role of the peripheral blood smear for the early diagnosis of bacteremia and/or fungemia: A case‐based approach

Li,

Huang,

Long

et al. 2023

Int J Lab Hematology

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Bacteremia is a predominant source of morbidity and mortality, with up to 37% mortality. 1 Bacteremia refers to the existence of bacteria in the blood stream, and blood cultures (BC) are the "gold standard" to diagnose bloodstream infections. Similarly, fungemia represents the occurrence of fungal pathogens in blood stream, caused by Candida, Trichosporon, Saccharomyces, and Fusarium species and so forth. Very few researches have described the detection of fungemia by review of routinely stained peripheral blood smears. However, the BC may cause false-negative results due to poor timing or insufficient blood collection, antibiotics application before blood sampling, intermittent blood collection with intermittent bacteremia. On the other hand, the observation of microorganisms on peripheral blood smear is unusual and should be regarded as a valuable indicator of overwhelming infection, supporting an early and rapid diagnosis of septicemia or fungemia. 2 The purpose of this retrospective study was to pay attention to the exhibition of bacteremia and/or fungemia by examination of peripheral blood smears, especially in critically ill individuals with nonspecific symptoms.Case 1: A 31-year-old young woman was hospitalized for investigation of coma presented with vaginal bleeding for 17 days, hypogastralgia for more than 5 h, worsening for 2 h and fecal incontinence once. Physical examination revealed that the patient was in a coma, with a pale face and insensitive to pain stimuli and light.Abdominal color ultrasound demonstrated pelvic effusion and highly suggestive of blood clot. A complete blood count showed severe anemia, mild leukocytosis, and thrombocytopenia (hemoglobin, 51 g/L [reference range: 115-150 g/L]); leukocytes, 10.21 Â 10 9 /L (reference range: 3.5-9.5 Â 10 9 /L); platelets, 37 Â 10 9 /L (reference range: 125-350 Â 10 9 /L). Other laboratory results indicated high levels of activated partial thromboplastin time (APTT, 73.9 s, [reference range: 22-38 s]), aspartate aminotransferase (AST, 5530 IU/L [reference range: 13-35 IU/L]) and alanine aminotransferase (ALT, 2440 IU/L [reference range: 7-40 IU/L]), and hypofibrinogenemia (0.85 g/L [reference range: 2-4 g/L]). Peripheral blood smear demonstrated the presence of neutrophilia with intracellular structures, exhibiting two definite forms of microorganisms: oval, yeast-like shape and micrococcus, suggestive of phagocytized fungi and cocci (Figure 1A,B). In particular, the buffy-coat method facilitated the detection of micrococcus. Blood cultures confirmed the presence of Candida glabrata and Enterococcus faecium. The patient's condition

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“…Xingqin Huang 2 Fang Long 3 Enle Wang 4 Yan Xi 5 Yun Zhang 6 1 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing,…”

Section: Funding Informationmentioning

confidence: 99%

mentioning

confidence: 99%

Critical role of the peripheral blood smear for the early diagnosis of bacteremia and/or fungemia: A case‐based approach

Li,

Huang,

Long

et al. 2023

Int J Lab Hematology

View full text Add to dashboard Cite

show abstract

A Critical Review of Diagnostic Methods for Disseminated Histoplasmosis with Special Focus on Resource-Limited Settings

Cited by 1 publication

References 67 publications

Critical role of the peripheral blood smear for the early diagnosis of bacteremia and/or fungemia: A case‐based approach

Critical role of the peripheral blood smear for the early diagnosis of bacteremia and/or fungemia: A case‐based approach

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