Mycobacterium leprae in bone marrow

Oliveira, Leonardo Rodrigues de; Maltos, André Luiz

doi:10.1016/j.bjhh.2014.05.010

Cited by 1 publication

(3 citation statements)

References 2 publications

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“…The presence of M. leprae in bone marrow aspirates or biopsies was already described in previous case reports (5,6). Even though major studies are necessary, some authors believe the presence of M. leprae in the bone marrow, especially in lepromatous leprosy, can act as a reservoir of the disease facilitating future relapses (8).…”

Section: Discussionmentioning

confidence: 84%

“…The majority of the cases involve the investigation of FUO, wasting syndrome, and cytopenias. In those cases, the main differential diagnosis was lymphoproliferative diseases that were considered less probable after the laboratory results revealed a normal pattern for serum protein electrophoresis (SPEP) and the absence of concerning findings for neoplasia on the abdomen and chest computerized tomography (CT) ( 4 – 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…It usually involves the peripheral nervous system and skin, in addition to mucous membranes in some instances (3). The presentation of leprosy related to bone marrow infiltration is rare with only a few case reports in the literature diagnosing leprosy by bone marrow biopsy or aspiration (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report

et al. 2022

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Mycobacterium leprae, the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of M. leprae in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of M. leprae in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%