2014
DOI: 10.1016/j.bjhh.2014.05.007
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Clinical complications in pregnant women with sickle cell disease: prospective study of factors predicting maternal death or near miss

Abstract: ObjectiveTo evaluate complications in pregnant women with sickle cell disease, especially those leading to maternal death or near miss (severe obstetric complications).MethodsA prospective cohort of 104 pregnant women registered in the Blood Center of Belo Horizonte (Hemominas Foundation) was followed up at high-risk prenatal units. They belonged to Group I (51 hemoglobin SS and three hemoglobin S/β0-thalassemia) or Group II (49 hemoglobin SC and one hemoglobin S/β+-thalassemia). Both groups had similar median… Show more

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Cited by 36 publications
(22 citation statements)
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“…Our study showed a significant difference in weight gain in favor of the HbSS / PHHF and HbSS / alpha-thal genotypes. The observed difference could be associated with the protective effects of HbF21 and alpha-thal 22. From the hematological variables, the HbSS genotype has a high number of WBCs, reticulocytes, and platelets.…”
Section: Discussionmentioning
confidence: 97%
“…Our study showed a significant difference in weight gain in favor of the HbSS / PHHF and HbSS / alpha-thal genotypes. The observed difference could be associated with the protective effects of HbF21 and alpha-thal 22. From the hematological variables, the HbSS genotype has a high number of WBCs, reticulocytes, and platelets.…”
Section: Discussionmentioning
confidence: 97%
“…Given the high risk of maternofetal morbidity, SC parturients would require care and monitoring similar to those of SS [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…Pregnant women with SCD have a higher risk of maternal and fetal mortality when compared to those with SCT or the population in general 23, 28, 29. A research that assessed the evolution of pregnancies in 34 women with SCD for a period of 12 years reported 26.6% of miscarriages, seven fetal losses (3 stillbirths and 4 miscarriages) and only one maternal death (2.9%) in the postpartum period due to ACS 28 .…”
Section: Discussionmentioning
confidence: 99%