A rare complication of continuous positive airway pressure treatment – rectus sheath hematoma: a case report

Yamanoğlu, Adnan; Bılgın, Serkan; Yamanoğlu, Nalan Gökçe Çelebi; Topal, Fatih Esad

doi:10.1016/j.bjane.2021.02.039

Cited by 1 publication

(1 citation statement)

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“…Clinical study showed that NIPPV could improve the survival in hypercapnia, stable COPD patients [ 11 ]. However, there was few COPD patients who receive acute or continuous NIPPV are at potential risk for serious complications such as pulmonary barotrauma and bleeding [ 12 , 13 ]. On this basis, we proposed for the first time the rehabilitation strategy of sequential NIPPV + IMT that make the inspiratory muscles get a full rest after a certain intensity load exercise.…”

Section: Introductionmentioning

confidence: 99%

Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway

Lei,

He,

et al. 2023

BMC Pulm Med

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Background Pulmonary rehabilitation training is of great significance for the prognosis of chronic obstructive pulmonary disease (COPD) patients. The purpose of this study was to investigate the therapeutic effect and pathway of a new sequential noninvasive positive pressure ventilation (NIPPV) + inspiratory muscle training (IMT) therapy. Methods A total of 100 COPD patients were enrolled and randomly divided into oxygen therapy (OT), NIPPV, IMT and sequential (NIPPV + IMT) group. Lung function, exercise endurance, quality of life, and dyspnea symptoms were examined and recorded. Then, reactive oxygen species (ROS), malonaldehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) levels were detected by enzyme-linked immunoassay, and suppressor of cytokine signaling 5 (SOCS5)/janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway expression changes were detected by quantitative real time-polymerase chain reaction (qRT-PCR) and western blot. A mouse model of COPD was then established to further verify the effects of SOCS5/JAK2/STAT3 pathways on lung function and oxidative stress. Results After 8 weeks of treatment, NIPPV, IMT or sequential (NIPPV + IMT) significantly improved exercise endurance, quality of life and dyspnea, reduced oxidative stress, promoted SOCS5 expression and inhibited the activation of JAK2/STAT3 pathway, and no significant effect was observed on lung function of COPD patients. Notably, sequential (NIPPV + IMT) showed better therapeutic outcomes than either IMT or NIPPV alone. Moreover, results at the animal level showed that overexpression of SOCS5 significantly reduced pulmonary inflammatory infiltration, pathological changes and oxidative stress levels in COPD mice, enhanced lung function, and inhibited the activation of JAK2/STAT3 pathway. Conclusion Our results elucidated that sequential (NIPPV + IMT) significantly relieved COPD development by regulating SOCS5/JAK2/STAT3 signaling-mediated oxidative stress.

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Section: Introductionmentioning

confidence: 99%