Linezolid a potential treatment for COVID-19 coinfections

Moghadam, Vahid Damanpak; Momenimovahed, Zohre; Ghorbani, Maryam; Khodadadi, Javad

doi:10.1016/j.bjane.2020.12.019

Cited by 10 publications

(10 citation statements)

References 3 publications

(2 reference statements)

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“…In the early stages of the pandemic, management protocols included azithromycin for its potential antiviral, anti-inflammatory, and IL-6 lowering properties [ 25 , 48 ]. Other antibiotics such as respiratory fluoroquinolones (moxifloxacin and levofloxacin), cephalosporins, and linezolid are sometimes also prescribed [ 49 , 50 ]. All patients included in this study were treated with one or more antibiotics; most were on a azithromycin/cephalosporin combination.…”

Section: Discussionmentioning

confidence: 99%

Oropharyngeal Candidiasis among Egyptian COVID-19 Patients: Clinical Characteristics, Species Identification, and Antifungal Susceptibility, with Disease Severity and Fungal Coinfection Prediction Models

et al. 2022

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The study aimed to investigate the causative species, antifungal susceptibility, and factors associated with oropharyngeal candidiasis (OPC) among Egyptian COVID-19 patients. This is an observational, case-controlled, single-center study that included three groups: COVID-19 patients (30), COVID-19 patients with OPC (39), and healthy individuals (31). Patients’ demographic data (age, sex), laboratory tests, comorbidities, treatment, and outcomes were included. Candida species were isolated from COVID-OPC patient’s oropharyngeal swabs by convenient microbiological methods. Isolated strains were tested for antimicrobial susceptibility, biofilm production, aspartyl protease, and phospholipase activities. The most common respiratory symptoms reported were dyspnea (36/39; 92.4%) and cough (33/39; 84.7%). Candida albicans was the most common isolated species, accounting for 74.36% (29/39), followed by Candida tropicalis and Candida glabrata (15.38% and 10.26%, respectively). Amphotericin was effective against all isolates, while fluconazole was effective against 61.5%. A total of 53.8% of the isolates were biofilm producers. The phospholipase activity of C. albicans was detected among 58.6% (17/29) of the isolates. Significant variables from this study were used to create two equations from a regression model that can predict the severity of disease course and liability to fungal infection, with a stativity of 87% and 91%, respectively. According to our findings, COVID-19 patients with moderate to severe infection under prolonged use of broad-spectrum antibiotics and corticosteroids should be considered a high-risk group for developing OPC, and prophylactic measures are recommended to be included in the treatment protocols. In addition, due to the increased rate of fluconazole resistance, other new antifungals should be considered.

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Section: Discussionmentioning

confidence: 99%

Oropharyngeal Candidiasis among Egyptian COVID-19 Patients: Clinical Characteristics, Species Identification, and Antifungal Susceptibility, with Disease Severity and Fungal Coinfection Prediction Models

et al. 2022

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“…As per literature survey Moghadam VD et al; 2021 this antibiotic named linezolid was a good treatment for bacterial nosocomial pneumonia with better clinical and microbiological efficacy as compared to other popular antibiotic (vancomycin) [18]. The superiority of linezolid is based on better penetration of respiratory secretions compared to vancomycin.…”

Section: Resultsmentioning

confidence: 99%

Linezolid as Potent Inhibitor of SARS-CoV-2 Nsp13 Helicase: Grid Based Docking Approach

Malik¹

2022

Middle East Res J Pharm Sci

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A diversified originator in humans and wildlife, the corona virus (COVID-19) is an enveloped RNA virus. Six different species have been shown to be the root of human sickness. Human diseases are greatly influenced by viral infections, and one of the most recent global epidemics is the appearance of the new corona. The SARS (Severe Acute Respiratory Syndrome) virus, a potentially fatal viral infection, was caused by the SS-RNA virus from the enveloped corona virus family. In many nations around the world, disease is rapidly expanding. 462,684 confirmed cases and 20,834 fatalities had been reported as of March 26, 2020, internationally. On March 11, 2020, COVID-19 was declared a pandemic by the World Health Organization (WHO). There are numerous medication trials ongoing, and some of the outcomes are encouraging. However, since there is no vaccine, the only approach to fight the virus is through preventative measures. Patients with bacterial nosocomial pneumonia were successfully treated with the antibiotic "Linezolid" by receiving an intravenous dose of 600 mg of linezolid every 12 hours for 7 to 10 days. All of the patients made a full recovery and were allowed to leave the hospital. Additionally, previous studies have shown that linezolid is more clinically and microbiologically effective than other antibiotics (vancomycin). The goal of the current study was to use a molecular docking approach to evaluate linezolid's potential against SAR-CoV-2 infection.

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“…The whole situation affected the psychological condition of patients. Previous studies ( Gunnell et al, 2020 ; Holmes et al, 2020 ; Sahin et al, 2020 ; Ayubi et al, 2021 ; Dibble and Connor, 2021 ; Kheirvari and Anbara, 2021 ; Moghadam et al, 2021 ; Rodrigues-Oliveira et al, 2021 ) have shown that the development of epidemic is of great public health importance, COVID-19 should be counted among the factors that bring sudden changes in the mental health of the population, which may be due to the fact of dynamic development of this disease. dramatic media coverage and own experience.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the epidemiological situation around the world, many medical sectors have been unable to provide their patients with the support they expected and to meet their treatment deadlines. At the beginning of the pandemic, there was a lack of more information about the potential impact of the pandemic on mental health ( Ayubi et al, 2021 ; Dibble and Connor, 2021 ; Moghadam et al, 2021 ). This means that we are ill-prepared to support communities facing the unprecedented COVID-19 pandemic ( Huang et al, 2020 ; Sahin et al, 2020 ; Kheirvari and Anbara, 2021 ; Rodrigues-Oliveira et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The Impact of the Epidemiological Situation Resulting From COVID-19 Pandemic on Selected Aspects of Mental Health Among Patients With Cancer–Silesia Province (Poland)

Grajek

Białek-Dratwa

2022

Front. Psychol.

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ObjectiveThe study aimed to assess the level of disease acceptance as well as the wellbeing and emotions that accompany cancer patients during the COVID-19 pandemic.Materials and MethodsThe study involved 1,000 patients of the oncology centers (Silesia, Poland). The following questionnaires were used for the study: WHO-5–Well-Being Index, BDI–Beck Depression Inventory, disease acceptance scale, and proprietary multiple-choice questions regarding the impact of the epidemic situation on the respondents’ lives so far. The questionnaire study was conducted twice: in March-October 2020 (the beginning of the COVID-19 pandemic in Poland) and March-October 2021 (renewed tightening of sanitary restrictions in Poland). The differences between the given periods were statistically analyzed.ResultsAt the time of the study, the respondents felt mainly anxiety related to the possibility of contracting COVID-19, the possibility of infecting a loved one, or staying in quarantine. Anxiety was also caused by the vision of poorer access to health services. Along with the duration of the epidemic, the acceptance of neoplastic disease has decreased and the incidence of depressive symptoms has increased.ConclusionThe wellbeing of the respondents deteriorated significantly during the pandemic. The respondents, in their daily functioning, were mainly accompanied by anxiety. The risk of depression has increased and the acceptance of the disease has decreased significantly.

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Linezolid a potential treatment for COVID-19 coinfections

Cited by 10 publications

References 3 publications

Oropharyngeal Candidiasis among Egyptian COVID-19 Patients: Clinical Characteristics, Species Identification, and Antifungal Susceptibility, with Disease Severity and Fungal Coinfection Prediction Models

Oropharyngeal Candidiasis among Egyptian COVID-19 Patients: Clinical Characteristics, Species Identification, and Antifungal Susceptibility, with Disease Severity and Fungal Coinfection Prediction Models

Linezolid as Potent Inhibitor of SARS-CoV-2 Nsp13 Helicase: Grid Based Docking Approach

The Impact of the Epidemiological Situation Resulting From COVID-19 Pandemic on Selected Aspects of Mental Health Among Patients With Cancer–Silesia Province (Poland)

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