Capsaicin topical cream (8%) for the treatment of myofascial pain syndrome

Romero, Valéria; Lara, Juliana R.; Otero-Espinar, Francisco J.; Salgado, Manoel Henrique; Módolo, Norma Sueli Pinheiro; Barros, Guilherme Antônio Moreira de

doi:10.1016/j.bjane.2019.06.008

Cited by 4 publications

(4 citation statements)

References 22 publications

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Section: Resultsmentioning

confidence: 99%

“…A total of 942 titles (PubMed, 84; Ovid SP, 839; Cochrane, 19) was retrieved, of which 936 were excluded based on the title and abstract. A total of 11 studies was further evaluated for full text analysis, of which 7 were excluded [15][16][17][18][19][20][21] (Table 1), 20 (2006) Model study for identifying pathophysiology of burning mouth syndrome. 3 Epstein and Marcoe 17 (1994) Capsaicin is used for neuropathic pain and trigeminal neuralgia.…”

Section: Study Selectionmentioning

confidence: 99%

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Burning measure for burning mouth syndrome: a systematic review

Tirupathi,

Malothu,

Allaparthi

et al. 2024

JKAOMS

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This current systematic review aimed to evaluate the current evidence on the effect of topical capsaicin application to alleviate symptoms related to burning mouth syndrome (BMS). PubMed, Ovid SP, and Cochrane were searched from 1980 to 2022 to identify relevant literature. A total of 942 titles (PubMed, 84; Ovid SP, 839; Cochrane, 19) was retrieved, of which 936 were excluded based on the title and abstract. A total of 11 studies were further evaluated for full text analysis, of which 7 were excluded. As a result, 4 articles were included for qualitative synthesis of data. Capsaicin as a mouthwash can have potential application in the treatment of symptoms related to burning mouth. The quality of available studies is moderate to low, and a well-designed randomized multicentric study comparing capsaicin with other active agents is planned to obtain more definitive conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Burning measure for burning mouth syndrome: a systematic review

Tirupathi,

Malothu,

Allaparthi

et al. 2024

JKAOMS

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“…The addition of one trial of duloxetine (n=236) 9 to an updated meta-analysis did not change prior conclusions of no effect of serotonin-norepinephrine reuptake inhibitors (SNRIs) on the risk of serious adverse events (SAEs) (20 RCTs, N=9,059, 1.6% vs. 2.6%, RR 0.92, 95% CI, 0.65 to 1.29, I 2 =0%) 9,[23][24][25][26][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] and a moderate risk of withdrawals due to adverse events (WAEs) (25 RCTs, N=10,207, 15.2% vs. 7.4%, RR 2.00, 95% CI, 1.72 to 2.35, I 2 =18%). 9,[23][24][25][26][27][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]…”

Section: Serotonin-norepinephrine Reuptake Inhibitormentioning

confidence: 99%

Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 2

Selph¹,

McDonagh²,

Pappas³

et al. 2022

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Background and PurposeThis is the third surveillance report for the 2020 report Nonopioid Pharmacologic Treatments for Chronic Pain (https://effectivehealthcare.ahrq.gov/products/nonopioid-chronicpain/research), 1 covering the period January to April 1, 2022. This report addressed benefits and harms of nonopioid pharmacologic treatments in adults with chronic pain (e.g., neuropathic pain, fibromyalgia, osteoarthritis, inflammatory arthritis, low back and neck pain, chronic headache, and sickle cell disease). Given the clinical and public health importance of this topic, it is important to identify new evidence that could impact practice or policy.

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“…Romero et al [ 10 ] reported that the local application of 8% Capsaicin cream is beneficial and well-tolerated by patients with myofascial pain syndrome.…”

Section: Introductionmentioning

confidence: 99%

The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review

Catalfamo

Marrone

Basilicata

et al. 2022

IJERPH

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Capsaicin is a chili peppers extract, genus Capsicum, commonly used as a food spice. Since ancient times, Capsaicin has been used as a “homeopathic remedy” for treating a wild range of pathological conditions but without any scientific knowledge about its action. Several studies have demonstrated its potentiality in cardiovascular, nephrological, nutritional, and other medical fields. Capsaicin exerts its actions thanks to the bond with transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 is a nociceptive receptor, and its activation starts with a neurosensitive impulse, responsible for a burning pain sensation. However, constant local application of Capsaicin desensitized neuronal cells and leads to relief from neuropathic pain. In this review, we analyze the potential adjuvant role of Capsaicin in the treatment of different pathological conditions either in internal medicine or dentistry. Moreover, we present our experience in five patients affected by oro-facial pain consequent to post-traumatic trigeminal neuropathy, not responsive to any remedy, and successfully treated with topical application of Capsaicin. The topical application of Capsaicin is safe, effective, and quite tolerated by patients. For these reasons, in addition to the already-proven beneficial actions in the internal field, it represents a promising method for the treatment of neuropathic oral diseases.

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Capsaicin topical cream (8%) for the treatment of myofascial pain syndrome

Cited by 4 publications

References 22 publications

Burning measure for burning mouth syndrome: a systematic review

Burning measure for burning mouth syndrome: a systematic review

Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 2

The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review

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