Addition of dexmedetomidine to bupivacaine in ultrasonography-guided paravertebral blockade potentiates postoperative pain relief among patients undergoing thoracotomy

Biçer, Cihangir; Ünalan, Esra Nur; Aksu, Recep; Önal, Ömer; Güneş, İbrahim

doi:10.1016/j.bjane.2018.12.004

Cited by 3 publications

(7 citation statements)

References 24 publications

(27 reference statements)

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“…To our understanding, dexmedetomidine has a pronounced role in reducing the reactivity of patients, preventing bronchospasm, and reducing the occurrence of symptoms such as coughing during recovery, which can ensure the smooth progress of extubation during recovery. However, the clinical dose of dexmedetomidine remains controversial [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Doses of Dexmedetomidine Combined with Thoracic Paravertebral Nerve Block Anesthesia on Agitation and Hemodynamics in Patients Undergoing Thoracotomy during Recovery

Baoli¹,

Yang²,

Shi³

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effect of different doses of dexmedetomidine combined with thoracic paravertebral nerve block anesthesia on agitation and hemodynamics in patients undergoing thoracotomy during recovery. Methods. One hundred patients who underwent thoracotomy in our hospital from August 2018 to April 2021 were enrolled and assigned (1 : 1 : 1 : 1) into 4 groups via the random number table method. The patients in the control group were treated with double-lumen tube general anesthesia + ropivacaine for thoracic paravertebral nerve block anesthesia; patients in experimental group A received double-lumen general anesthesia +0.5 μg·kg−1 dexmedetomidine + ropivacaine for thoracic paravertebral nerve block anesthesia; patients in experimental group B received thoracic paravertebral nerve block anesthesia with double-lumen general anesthesia +1.0 μg·kg−1 dexmedetomidine + ropivacaine; patients in experimental group C received thoracic paravertebral nerve block anesthesia with double-lumen general anesthesia +1.5 μg·kg−1 dexmedetomidine + ropivacaine. The postoperative recovery time and visual analog scale (VAS), level of hemodynamics (heart rate (HR), mean arterial pressure (MAP)), agitation during the recovery period, and complications were compared amongst the 4 groups of patients at different time points. Results. The postoperative VAS scores of patients in groups B2 and B3 were slightly lower than those of patients in groups A and B1, but a one-way analysis of variance revealed no statistical difference in the postoperative recovery time and VAS pain scores of the four groups ( P > 0.05 ), and the recovery time of patients in experimental group C was slightly higher than that of patients in group B2. At T0 and T1, there was no significant difference in the levels of HR and MAP among the four groups ( P > 0.05 ). The levels of HR and MAP of the patients in groups B2 and B3 were significantly different from the patients in the control group and experimental group A at T2 and T3 ( P < 0.05 ). The patients in experimental group B and experimental group C showed better outcomes than those in the control group and experimental group A in the assessment of agitation during the recovery period ( P < 0.05 ). There was no significant difference in the incidence of complications among the four groups ( P > 0.05 ). Conclusion. In line with the principle of preference for a small anesthesia dose, 1.0 μg·kg−1 dose of dexmedetomidine combined with ropivacaine produces a pronounced efficacy in patients undergoing thoracotomy. It effectively controls the occurrence of agitation during the recovery period and maintains the stability of the patient’s hemodynamics, with a high clinical safety profile.

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Section: Discussionmentioning

confidence: 99%

Effects of Different Doses of Dexmedetomidine Combined with Thoracic Paravertebral Nerve Block Anesthesia on Agitation and Hemodynamics in Patients Undergoing Thoracotomy during Recovery

Baoli¹,

Yang²,

Shi³

2022

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…In the selection process, eight articles were excluded due to inadequate comparators or incomplete data. Thus, 12 articles were included in this scoping review [14][15][16][17][18][19][20][21][22][23][24][25] . The reference list of the included articles was analyzed to identify relevant articles, but no new articles were included in this process (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Length of analgesia was evaluated in all included articles [14][15][16][17][18][19][20][21][22][23][24][25] . The results were favorable to the group without an opioid in six articles 15,18,[20][21][22][23][24] . Kaiser et al 15 reported the effectiveness of the group without opioids [intercostal nerve infusion of 0.5% bupivacaine (20 mL) + continuous infusion of 0.5% bupivacaine (0.1 mL/kg/h) + ornipressin (0.05 U/mL) for 5 days] on the second day after surgery.…”

Section: Resultsmentioning

confidence: 99%

“…Effectiveness of analgesia was seen as length of analgesia. Six studies reported favorable results 15,18,20,[22][23][24] ; however, the time of analgesia was different between studies. Some authors of the included studies reported effectiveness in rest position and others in the cough effort.…”

Section: Discussionmentioning

confidence: 99%

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