Effects of local anesthetics on wound healing

Kesi̇ci̇, Sevgi; Kesici, Uğur; Ulusoy, Hülya; Ertürküner, Pelin; Türkmen, Aygen; Arda, Oktay

doi:10.1016/j.bjane.2018.01.020

Cited by 12 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Dogan et al 13 , there is delay in wound healing with the use of lidocaine, and with the reduced tension strength of collagen fibers; other authors corroborate the macroscopic findings of this research, where no significant differences were observed between the healing processes 14,15 .…”

Section: ■ Discussionsupporting

confidence: 83%

Topical application of lidocaine or bupivacaine in the healing of surgical wounds in dogs

et al. 2020

View full text Add to dashboard Cite

Conception and design of the study, technical procedures, manuscript preparation and writing, critical revision, final approval. II Graduate student, FCAV-UNESP, Jaboticabal-SP, Brazil. Acquisition, analysis and interpretation of data; manuscript preparation. III Post-doctorate, Postgraduate Program in Veterinary Surgery, FCAV-UNESP, Jaboticabal-SP, Brazil. Conception and design of the study, analysis and interpretation of data, technical procedures, statistics analysis, manuscript preparation and writing, critical revision, final approval. IV Fellow PhD degree, Postgraduate Program in Veterinary Surgery, FCAV-UNESP, Jaboticabal-SP, Brazil. Acquisition of data, technical procedures, statistics analysis, manuscript preparation and writing, critical revision, final approval.

show abstract

Section: ■ Discussionsupporting

confidence: 83%

Topical application of lidocaine or bupivacaine in the healing of surgical wounds in dogs

et al. 2020

View full text Add to dashboard Cite

show abstract

“…For permeation tests, the base of the cellular insert with full thickness skin was placed as separator membrane in Franz cells (A), usingraw lidocaine hydrochloride (LID) or drug-loaded GMS-LID4 particles (5) in the donor compartment. The release medium was PBS pH 7.4 (6). Another part of the experiment tested the permeation of LID from GMS-LID4 particles directly in the cellular inserts, using (B.1) either full thickness skin substitute (7) containing the keratinocyte layer, (B.2) or dermal tissue (8) without epidermis as membrane.…”

Section: Figurementioning

confidence: 99%

“…80% of patients suffering from venous leg ulcers report acute or chronic wound pain, which causes discomfort, stress, anxiety and, overall, poor quality of life [ 2 , 3 , 4 , 5 ]. Local anesthetics, and lidocaine hydrochloride (LID) in particular, have been used for decades to reduce wound pain (e.g., in post-operative analgesia) without hampering the physiological scarring process [ 6 , 7 ]. The mechanism of action of LID is the specific interaction and blockage of sodium channels of the sensorial neurons [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

et al. 2020

View full text Add to dashboard Cite

The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) loaded with lidocaine hydrochloride (LID) were processed and the formulation was evaluated regarding its ability to deliver the drug at the wound site and through the skin barrier. The SLMPs of glyceryl monostearate (GMS) were prepared with different LID contents (0, 1, 2, 4, and 10 wt.%) using the solvent-free and one-step PGSS (Particles from Gas-Saturated Solutions) technique. PGSS exploits the use of supercritical CO2 (scCO2) as a plasticizer for lipids and as pressurizing agent for the atomization of particles. The SLMPs were characterized in terms of shape, size, and morphology (SEM), physicochemical properties (ATR-IR, XRD), and drug content and release behavior. An in vitro test for the evaluation of the influence of the wound environment on the LID release rate from SLMPs was studied using different bioengineered human skin substitutes obtained by 3D-bioprinting. Finally, the antimicrobial activity of the SLMPs was evaluated against three relevant bacteria in wound infections (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). SLMPs processed with 10 wt.% of LID showed a remarkable performance to provide effective doses for pain relief and preventive infection effects.

show abstract

“…The increased in the inflammatory responses in the 3 rd day may be due to the effects of mebivacaine on increasing cytokine production which enhance inflammatory responses [27] this will promote healing by epithelial cell migration and remodeling of matrices in extracellular place which enhance granulation tissue formation in 6 th day of treatment [28] . The positive effects of mebevacaine on healing also may be due to its antibacterial effects (9) also it may affect the maturation and sequence of collagen fibers [29] .…”

Section: Discussion Of Resultsmentioning

confidence: 99%

Impact of Local Anesthesia on Wound Healing

2020

IJFMT

View full text Add to dashboard Cite

Different local anesthetics produce multiple effects on wound healing, although this effect did not demonestrated clearly in experimental study. This study aimedto evaluate the effects of several local anesthetics (lidocaine, articaine, mepivacaine) on healing of oral mucosal wound healing in experimental rabbits by histological examination.The study was conducted on eight healthy adult male New Zealand white rabbits which divided into four group(n=2) control group which received no treatment group two (received lidocaine 2% with adrenalin) group three (received mepivacaine) and group four (received articaine 4%). oral mucosal wound were initiated experimentally in all group and each group received their treatment by local application one time daily for six day(except control group) in the third day half of the animal were sacrificed in each group and histological examination for the wound area were conducted , the remaining animal were sacrificed in the sixth day of treatment and histological examination were made for the wound area to compare the result between the four group. The mepivacaine group produce better result (enhance healing of the oral mucosal wound) followed by atricaine and lidocaine group compared with control one. This study showed that different type of local anesthesia produces different effects on wound healing manufisted histologically and clinically.

show abstract

Effects of local anesthetics on wound healing

Cited by 12 publications

References 9 publications

Topical application of lidocaine or bupivacaine in the healing of surgical wounds in dogs

Topical application of lidocaine or bupivacaine in the healing of surgical wounds in dogs

Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

Impact of Local Anesthesia on Wound Healing

Contact Info

Product

Resources

About