The effect of pheniramine on fentanyl-induced cough: a randomized, double blinded, placebo controlled clinical study

Arslan, Zakir; Çalık, Eyüp Serhat; Kaplan, Bekir; Ahıskalıoğlu, Elif Oral

doi:10.1016/j.bjane.2014.11.018

Brazilian Journal of Anesthesiology (English Edition)

2016

DOI: 10.1016/j.bjane.2014.11.018

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The effect of pheniramine on fentanyl-induced cough: a randomized, double blinded, placebo controlled clinical study

Zakir Arslan

Eyüp Serhat Çalık

Bekir Kaplan

et al.

Abstract: Intravenous pheniramine is as effective as lidocaine in preventing fentayl-induced cough. Our results emphasize that pheniramine is a convenient drug to decrease this cough.

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Cited by 2 publications

References 23 publications

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Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis

Tan

Liu

et al. 2018

Sci Rep

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To evaluate whether different doses of intravenous lidocaine are effective at preventing fentanyl-induced cough (FIC), we searched PubMed, Scopus, Cochrane Library, EMBASE and Web of Science, according to predefined criteria, for all articles published until June 2017. A meta-analysis and subgroup analysis were performed by combining the reported incidence of FIC. The odds ratio (OR) was used as a summary statistic. Eleven articles were included, with 965 patients in the lidocaine group and 745 patients in the control group. A pooled analysis indicated that the overall incidence of FIC was significantly different between the lidocaine group and the control group (OR, 0.27; 95% confidence interval (CI), 0.21–0.35; P < 0.05), as well as between the adult and paediatric subgroups. Sensitivity analysis showed that the results were stable. Subgroup analyses showed that compared to a placebo, both low (0.5–1.0 mg/kg) and high doses of lidocaine (1.5–2.0 mg/kg) were effective at reducing FIC incidence. There was no significant difference between low or high doses of lidocaine. Fentanyl doses added no significant heterogeneity as shown by meta-regression. The findings of this meta-analysis indicate that prophylactic intravenous lidocaine is effective at preventing FIC in both adults and children.

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Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis

Tan

Liu

et al. 2018

Sci Rep

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Effect of preoperative incentive spirometry on fentanyl-induced cough: a prospective, randomized, controlled study

Goyal

Bhargava

Baj

2017

Korean J Anesthesiol

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BackgroundFentanyl-induced cough (FIC) has a reported incidence of 13–65% on induction of anesthesia. Incentive spirometry (IS) creates forceful inspiration, while stretching pulmonary receptors. We postulated that spirometry just before the fentanyl (F) bolus would decrease the incidence and severity of FIC.MethodsThis study enrolled 200 patients aged 18–60 years and with American Society of Anesthesiologists status I or II. The patients were allocated to two groups of 100 patients each depending on whether they received preoperative incentive spirometry before fentanyl administration. Patients in the F+IS group performed incentive spirometry 10 times just before an intravenous bolus of 3 µg/kg fentanyl in the operating room. The onset time and number of coughs after fentanyl injection were recorded as primary outcomes. Any significant changes in blood pressure, heart rate, or adverse effects of the drug were recorded as secondary outcomes.ResultsPatients in the F+IS group had a significantly lower incidence of FIC than in the F group (6% vs. 26%) (P < 0.05). The severity of cough in the F+IS group was also significantly lower than that in group F (mild, 5 vs. 17; moderate 1 vs. 7; severe, 0 vs. 2) (P < 0.05). The median onset time was comparable in both groups (9 s [range: 6–12 s] in both groups).ConclusionsPreoperative incentive spirometry significantly reduces the incidence and severity of FIC when performed just before fentanyl administration.

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The effect of pheniramine on fentanyl-induced cough: a randomized, double blinded, placebo controlled clinical study

Abstract: Intravenous pheniramine is as effective as lidocaine in preventing fentayl-induced cough. Our results emphasize that pheniramine is a convenient drug to decrease this cough.

Cited by 2 publications

References 23 publications

Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis

Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis

Effect of preoperative incentive spirometry on fentanyl-induced cough: a prospective, randomized, controlled study

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