Influence of preoperative propranolol on cardiac index during the anhepatic phase of liver transplantation

Seiberlich, Emerson; Sanches, Marcelo Dias; Morais, Bruno; Maciel, Jader F.

doi:10.1016/j.bjane.2014.02.017

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Preoperative use of propranolol tended to independently predict CVE, in contrast to reports by others [ 5 , 15 ]. Beta-blocker use in general may be associated with postoperative adverse outcome in patients undergoing major surgery [ 16 ].…”

Section: Discussioncontrasting

confidence: 99%

In-hospital cardiovascular events after liver transplantation: predictors and long-term outcome

et al. 2018

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IntroductionLiver transplantation has emerged as a successful therapy for end-stage liver disease. However, cardiovascular mortality is the leading cause of fatality in the postoperative period. The aim of this study was to reveal the prevalence and identify risk factors of early cardiovascular events (CVEs).MethodsWe performed a retrospective study of all consecutive patients who underwent a primary liver transplantation from 1986 to 2017 (n = 916). We investigated the occurrence of in-hospital CVEs, their predictors, and short- and long-term outcome.ResultsThe prevalence of CVEs was 11%. The adjusted analysis showed that higher age (OR 1.06, 95% CI 1.03–1.09), higher MELD score (OR 1.04, 95% CI 1.01–1.07 CI) and sinus tachycardia at time of screening (OR 3.12, 95% CI 1.45–6.72) were positive predictors for a CVE. Preoperative propranolol use showed a trend towards a higher risk of CVE (OR 1.66, 95% CI 1.00–2.77, p = 0.051). In a sub-analysis of patients where echocardiography data were available (n = 597), a larger left atrial diameter and a higher E/E′ ratio were related to early CVEs. Ten-year survival in 30-day survivors was favourable (68.6%; 56.0% vs. 69.8% in the CVE+ vs. the CVE-group, respectively, p = 0.056).DiscussionIn conclusion, besides known risk factors (age and MELD score), sinus tachycardia (related to the presence of acute liver failure and cirrhosis) was an independent predictor for CVE after liver transplantation.

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Section: Discussioncontrasting

confidence: 99%

In-hospital cardiovascular events after liver transplantation: predictors and long-term outcome

et al. 2018

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Pulmonary injury at the anhepatic phase without veno-venous bypass in portal hypertensive rats

Zhao

Zeng

Ren

et al. 2016

Clinical and Experimental Hypertension

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Influence of preoperative propranolol on cardiac index during the anhepatic phase of liver transplantation

Abstract: The use of propranolol before transplantation as prophylaxis for gastrointestinal bleeding may be considered safe, as it was not associated with worsening of cardiac index in anhepatic phase of liver transplantation.

Cited by 2 publications

References 23 publications

In-hospital cardiovascular events after liver transplantation: predictors and long-term outcome

In-hospital cardiovascular events after liver transplantation: predictors and long-term outcome

Pulmonary injury at the anhepatic phase without veno-venous bypass in portal hypertensive rats

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