A Associação de Haloperidol, Dexametasona e Ondansetrona Reduz a Intensidade de Náusea, Dor e Consumo de Morﬁna após Gastrectomia Vertical Laparoscópica

Benevides, Márcio Luiz; Oliveira, Sergio Ricardo Lopes de; Aguilar-Nascimento, José Eduardo de

doi:10.1016/j.bjan.2012.07.011

Cited by 15 publications

(1 citation statement)

References 20 publications

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“…Internationally, the corticosteroid drug most commonly used for PONV prevention is dexamethasone [1,2]. In reports on the efficacy of corticosteroids in bariatric surgery, parenterally administered dexamethasone has been used in multimodal therapies [3,4,5]. In Scandinavia betamethasone is often the drug used [6,7].…”

Section: Introductionmentioning

confidence: 99%

Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Nordin¹,

Nordlund²,

Lindqvist

et al. 2016

Journal of Gastrointestinal Surgery

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Section: Introductionmentioning

confidence: 99%

Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Nordin¹,

Nordlund²,

Lindqvist

et al. 2016

Journal of Gastrointestinal Surgery

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Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

Weibel

Rücker

Eberhart

et al. 2020

Cochrane Database of Systematic Reviews

102

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Haloperidol Versus 5‐HT₃ Receptor Antagonists for Postoperative Vomiting and QTc Prolongation: A Noninferiority Meta‐Analysis and Trial Sequential Analysis of Randomized Controlled Trials

Singh

Borle

Makkar

et al. 2017

The Journal of Clinical Pharma

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Haloperidol is an antipsychotic with well-known antiemetic potential. It is underutilized for postoperative nausea vomiting due to reported corrected QT interval (QTc) prolongation. This meta-analysis evaluates its safety and efficacy as an antiemetic in the perioperative period. Trials comparing haloperidol to 5-HT -receptor antagonists (5-HT -RA) for 24 postoperative vomiting incidences published up to May 2017 were searched in the medical database. Comparisons were made for antiemetic efficiency variables (vomiting incidence, rescue antiemetic need, and patients with complete response) during early (until 6 hours) and late postoperative phases. Eight randomized controlled double-blinded trials were included in the final analysis. Twenty-four-hour vomiting incidence was similar in groups (fixed effects, P = 0.52, I = 0%). Trial-sequential analysis confirmed noninferiority of haloperidol over 5-HT -RAs (α = 5%, β = 20%, δ = 10%), with "information size" being 859 (required > 812). Pooled results did not demonstrate superiority/inferiority of 5-HT -RAs over haloperidol in all other antiemetic efficacy variables (early and delayed). Negligible heterogeneity was found in all the comparisons made. Pooled Mantel Haenszel odds ratio for QTc prolongation was equivalent in both groups (fixed effects, P = 0.23, I = 0%). The mean dose of haloperidol used was 1.34 mg, and no trial reported extrapyramidal side effects. Trial-sequential analysis showed statistical equivalence (α = 5%, β = 20%, δ = 10%), with information size being 745 (required > 591). Publication bias was unlikely (Egger test, X-intercept = 2.07, P = 0.10). We conclude that haloperidol is equivalent to the well-established 5-HT -RAs in preventing vomiting during the first day after surgery. The incidence of QTc prolongation with haloperidol is statistically equivalent to 5-HT -RAs and thus should not be the factor that discourages its use for treatment/prophylaxis of postoperative nausea vomiting.

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A Associação de Haloperidol, Dexametasona e Ondansetrona Reduz a Intensidade de Náusea, Dor e Consumo de Morﬁna após Gastrectomia Vertical Laparoscópica

Abstract: The combination of haloperidol, ondansetron, and dexamethasone reduced nausea and pain intensity and morphine consumption in postoperative obese patients undergoing LSG.

Cited by 15 publications

References 20 publications

Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

Haloperidol Versus 5‐HT₃ Receptor Antagonists for Postoperative Vomiting and QTc Prolongation: A Noninferiority Meta‐Analysis and Trial Sequential Analysis of Randomized Controlled Trials

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A Associação de Haloperidol, Dexametasona e Ondansetrona Reduz a Intensidade de Náusea, Dor e Consumo de Morﬁna após Gastrectomia Vertical Laparoscópica

Abstract: The combination of haloperidol, ondansetron, and dexamethasone reduced nausea and pain intensity and morphine consumption in postoperative obese patients undergoing LSG.

Cited by 15 publications

References 20 publications

Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Corticosteroids or Not for Postoperative Nausea: A Double-Blinded Randomized Study

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

Haloperidol Versus 5‐HT3 Receptor Antagonists for Postoperative Vomiting and QTc Prolongation: A Noninferiority Meta‐Analysis and Trial Sequential Analysis of Randomized Controlled Trials

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Haloperidol Versus 5‐HT₃ Receptor Antagonists for Postoperative Vomiting and QTc Prolongation: A Noninferiority Meta‐Analysis and Trial Sequential Analysis of Randomized Controlled Trials