Rhino-orbito-cerebral mucormycosis caused by Rhizopus microsporus var. microsporus in a diabetic patient with COVID-19

Munhoz, Sandy Daniele Germano; Lellis, Rute Facchini; Reis, Ana Paula Carvalho; Negro, G. Del; Sousa, Maria Gloria Teixeira; Veasey, John Verrinder

doi:10.1016/j.abd.2022.02.001

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…In Brazil, Bonates [41] reported a case of mucormycosis in a male patient from Manaus/Brazil, diabetic, presenting diabetic ketoacidosis and ocular infection, who tested immunoglobulin G (IgG) positive for SARS CoV-2, presenting flu-like symptoms; the patient had necrosis in the region of the nose, orbits and palate and died, and the sequencing test showed 99% similarity with Rhizopus oryzae. In Brazil, Munhoz [42], presented a case of rhino-orbito-cerebral mucormycosis in a diabetic patient hospitalized for COVID-19 whose diagnosis was confirmed by identifying the agent Rhizopus microsporus var. microsporus.…”

Section: Reports Of Immunosuppression In Cases Of Sars-covmentioning

confidence: 99%

Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship

Mariscal¹,

Matias²,

Almeida³

et al. 2023

AiM

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Background: COVID-19 is a rapidly transmissible pneumonia-like illness caused by SARS-CoV-2 that out broke in China in 2019 and is currently circulating worldwide. In the current context of the SARS-CoV-2 pandemic, complications are observed in clinical settings for the treatment of severe COVID-19 disease in nosocomial settings, due to cases of fungal co-infections. Objective: To carry out a review on fungal infections associated with respiratory infections caused by COVID-19 (Sars-Cov-2) and their aggravation. Methodology: The purpose of this study is to inform the reader about the characteristics of SARS-CoV-2 and the main fungal species that are affecting patients undergoing treatment for severe COVID-19, provoking discussion of the importance of the proposed topic, in relation to co-infections by different fungal microorganisms. Result: 80 scientific studies were selected, resulting from patients with COVID-19 and most commonly observed in patients with a history of comorbidities such as diabetes mellitus, hypertension, kidney disease, severe liver disease, oncological diseases, obesity and with severe COVID-19. These data do not represent the total number of records of the disease in the world, but cases reported by researchers in their series, showing the overlapping of fungal co-infection through the compromised immune status due to the use of therapeutic drugs, dysregulation of the microbiota, How to cite this paper: Mariscal, A.

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Section: Reports Of Immunosuppression In Cases Of Sars-covmentioning

confidence: 99%

Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship

Mariscal¹,

Matias²,

Almeida³

et al. 2023

AiM

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“…To date, five cases of CAM have been reported in Brazil, one in Manaus 10 , and four in São Paulo 9,11,12 . All patients had rhinocerebral infection, four had a previous diagnosis of diabetes, and three had severe COVID-19 requiring mechanical ventilation, with one death.…”

mentioning

confidence: 99%

“…A published review of 80 CAM reports and case series also described rhinocerebral infections as the most common site of infection 4 . The authors highlighted that the COVID-19 pandemic poses a substantial risk for invasive fungal infections, especially because of the increased number of intensive care patients, long hospitalizations, antibiotic use, and systemic corticosteroids 8,11,12,14 . Additionally, corticosteroids were the only therapy with an impact on mortality in the first wave, and their prolonged use significantly altered glycemia in patients with diabetes.…”

mentioning

confidence: 99%

Increase in mucormycosis hospitalizations in southeastern Brazil during the COVID-19 pandemic: a 2010-2021 time series

Santos

Sartori

Bueno

et al. 2023

Rev. Soc. Bras. Med. Trop.

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Background: Mucormycosis is a severe invasive fungal disease. During the coronavirus disease 2019 (COVID-19) pandemic, outbreaks have been reported worldwide, but epidemiological studies are still scarce in Brazil. Methods:We conducted a time-series cohort hospitalization study (2010-2021) in southeastern Brazil.Results: There were 311 cases (85 during the pandemic), with significant (P < 0.05) involvement of patients older than 40 years (84%), white patients (78%), rhinocerebral site (63%), and São Paulo State residents (84%).Conclusions: Mucormycosis hospitalizations were highly prevalent. Further studies are needed to assess the burden of COVID-19 on mucormycosis in Brazil.

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Rhino-orbito-cerebral mucormycosis caused by Rhizopus microsporus var. microsporus in a diabetic patient with COVID-19

Cited by 2 publications

References 8 publications

Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship

Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship

Increase in mucormycosis hospitalizations in southeastern Brazil during the COVID-19 pandemic: a 2010-2021 time series

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