Efficacy of sunscreen with photolyase or regular sunscreen associated with topical antioxidants in treating advanced photodamage and cutaneous field cancerization: a randomized clinical trial

Alvares, Bruno Augusto; Miola, Anna Carolina; Schmitt, Juliano Vilaverde; Miot, Hélio Amante; Abbade, Luciana Patrícia Fernandes

doi:10.1016/j.abd.2021.06.005

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…Antioxidants are synthesized by microalgae commonly as a response to environmental stress, mainly to avoid oxidative stress [ 63 ]. The microalgae-derived antioxidants can be used in cosmeceutical applications such as moisturizers and sunscreens to prevent and treat multiple skin conditions from photoaging to skin cancer [ 87 , 88 , 89 ].…”

Section: Antioxidantsmentioning

confidence: 99%

Microalgae Bioactive Compounds to Topical Applications Products—A Review

et al. 2022

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Microalgae are complex photosynthetic organisms found in marine and freshwater environments that produce valuable metabolites. Microalgae-derived metabolites have gained remarkable attention in different industrial biotechnological processes and pharmaceutical and cosmetic industries due to their multiple properties, including antioxidant, anti-aging, anti-cancer, phycoimmunomodulatory, anti-inflammatory, and antimicrobial activities. These properties are recognized as promising components for state-of-the-art cosmetics and cosmeceutical formulations. Efforts are being made to develop natural, non-toxic, and environmentally friendly products that replace synthetic products. This review summarizes some potential cosmeceutical applications of microalgae-derived biomolecules, their mechanisms of action, and extraction methods.

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Section: Antioxidantsmentioning

confidence: 99%

Microalgae Bioactive Compounds to Topical Applications Products—A Review

et al. 2022

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“…In contrast, a recent study included 40 individuals with AKs on the forearms, randomized to apply regular sunscreen or sunscreen with photolyase (SCPL). The use of SCPL did not promote differences in the reduction of the AK count, photoaging scale score, or the AK severity on the forearms when compared to common sunscreen, corroborating that the isolated use of sunscreen effectively contributes to reducing the AK count [13].…”

Section: Patient Demographic Data Are Presented In Tablementioning

confidence: 66%

Effectiveness and safety of 5% nicotinamide cream following cryosurgery in skin field cancerization: a randomized, double-blind, placebo-controlled clinical trial

Martins

Miot

Miola

2023

Preprint

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Individuals with multiple actinic keratoses (AKs) in the same area have an active skin field cancerization (SFC). The treatment of AKs and SFC reduces the recurrence of AKs and the appearance of squamous cell carcinomas (SCCs). Recently, oral nicotinamide (NIC) was proposed as effective in the chemoprevention of SCC and AKs, but there have been no clinical trials with topical NIC as a treatment for AKs and SFC. Thus, we conducted a prospective, randomized, double-blind, self-controlled trial to evaluate the efficacy and safety of 5% NIC cream in treating SFC after cryotherapy with liquid nitrogen (NL) for AKs. Subjects with between three and 10 AKs on the forearms received cryotherapy with NL on the AKs, and the forearms were randomized to receive: 5% NIC cream b.i.d. for 56 days or placebo cream (PLAC) at the same dosage, started 14 days after NL. The primary outcome was the percentage reduction in the AK count on D70. Secondary endpoints were the complete clearance and reduction of SFC activity at D70. The sample size was defined to detect a difference higher than 15% between the groups (power of 0.9, alpha of 0.05, and dropout estimate of 10%), which resulted in 40 forearms per group. After 70 days, there was a 61% (95% CI 50─72%) reduction in the AK count in NIC versus 56% (95% CI 44─68%) in PLAC (p = 0.698). Complete clearance was achieved in 21% (95% CI 7─37%) of NIC versus 17% (95% CI 4─31%) of PLAC (p = 0.440). An interim analysis was performed after the last evaluation of the 26th subject, and the difference between the groups did not reach 15%; thus, the study was discontinued due to futility. No adverse effects were reported. Our results suggest that in the treatment of inflammatory dermatoses, the anti-inflammatory capacity of NIC is not sufficient to reduce SFC activity. The present study has limitations: it is monocentric with homogeneous subjects and a short duration between intervention and follow-up. Topical treatment with 5% NIC was safe in immunocompetent adults with AK and SFC; however, it was not superior to placebo in reducing AKs or SFC activity.

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“…When comparing online recruitment to traditional offline recruitment strategies, online strategies appear more time-efficient. Our review of the published literature on AK from the past 10 years highlighted the time efficiency of an online recruitment approach for RCTs in dermato-oncology ( Table 2 ) [ [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] ]. A review by Jacques RM et al of the recruitment rates using conventional strategies in 388 RCTs between 1997 and 2020 found that the median patient recruitment rate per site was 0.95 per month (0.03 per day) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Accelerating patient recruitment using social media: Early adopter experience from a good clinical practice-monitored randomized controlled phase I/IIa clinical trial on actinic keratosis

Ortner,

Zibert,

Budnik

et al. 2024

Contemporary Clinical Trials Communications

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Efficacy of sunscreen with photolyase or regular sunscreen associated with topical antioxidants in treating advanced photodamage and cutaneous field cancerization: a randomized clinical trial

Cited by 9 publications

References 24 publications

Microalgae Bioactive Compounds to Topical Applications Products—A Review

Microalgae Bioactive Compounds to Topical Applications Products—A Review

Effectiveness and safety of 5% nicotinamide cream following cryosurgery in skin field cancerization: a randomized, double-blind, placebo-controlled clinical trial

Accelerating patient recruitment using social media: Early adopter experience from a good clinical practice-monitored randomized controlled phase I/IIa clinical trial on actinic keratosis

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